2-allyl-6-morpholin-4-yl-benzo[de]isoquinoline-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-allyl-6-morpholin-4-yl-benzo[de]isoquinoline-1,3-dione
• 英文别名: 2-Allyl-6-(4-morpholinyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione；6-morpholin-4-yl-2-prop-2-enylbenzo[de]isoquinoline-1,3-dione
• 化学式: C₁₉H₁₈N₂O₃
• mdl: MFCD00387946
• 分子量: 322.364
• InChiKey: HXBXMNCIDQBCHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苊 在 sodium dichromate 、 溴 、 四丁基硫酸氢铵 、 potassium carbonate 、 溶剂黄146 、 potassium hydroxide 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 30.0h， 生成 2-allyl-6-morpholin-4-yl-benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  Synthesis, in vitro evaluation and DNA interaction studies of N-allyl naphthalimide analogues as anticancer agents

  摘要：

  已合成并评估了一系列2-烯丙基-6-取代苯并[de]异喹啉-1,3-二酮类化合物的体外抗肿瘤活性和DNA插入作用。

  DOI：

  10.1039/c5ra00925a

文献信息

• Screening methods for identifying specific Staphylococcus aureus inhibitors
  申请人：Guenther Richard H.

  公开号：US10316371B2

  公开（公告）日：2019-06-11

  Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.

  本文描述了抑制金黄色葡萄球菌繁殖的方法和筛选抑制金黄色葡萄球菌繁殖的化合物的方法。一种抑制金黄色葡萄球菌繁殖的方法包括抑制或稳定金黄色葡萄球菌中特定金黄色葡萄球菌 tRNA 的核糖体结合，其抑制量足以抑制金黄色葡萄球菌蛋白质的表达。筛选可抑制金黄色葡萄球菌繁殖的化合物的方法包括将特异的金黄色葡萄球菌tRNA与核糖体接触，该核糖体在试验化合物和编码蛋氨酸和精氨酸（即包括序列AUGAGA）的mRNA存在的情况下结合该tRNA，然后确定该化合物是否抑制该tRNA的结合。
• SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS
  申请人：Guenther Richard H.

  公开号：US20140163037A1

  公开（公告）日：2014-06-12

  Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.
• [EN] SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS<br/>[FR] PROCÉDÉS DE CRIBLAGE POUR L'IDENTIFICATION D'INHIBITEURS SPÉCIFIQUES DE STAPHYLOCCOCUS AUREUS
  申请人：TRANA DISCOVERY INC

  公开号：WO2012135416A1

  公开（公告）日：2012-10-04

  Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.
• 10.1016/j.dyepig.2024.112386
  作者：Oshchepkov, Maxim、Tkachenko, Sergey、Popov, Konstantin、Semyonkin, Aleksey、Yuriev, Danil、Solovieva, Inna、Melnikov, Pavel、Malinovskaya, Julia A.、Oshchepkov, Alexander

  DOI：10.1016/j.dyepig.2024.112386

  日期：——
• Synthesis, in vitro evaluation and DNA interaction studies of N-allyl naphthalimide analogues as anticancer agents
  作者：Meenakshi Verma、Vijay Luxami、Kamaldeep Paul

  DOI：10.1039/c5ra00925a

  日期：——

  A novel series of 2-allyl-6-substituted-benzo[de]isquinoline-1,3-diones has been synthesized and evaluated for their in vitro antitumor activities and DNA intercalation.

  已合成并评估了一系列2-烯丙基-6-取代苯并[de]异喹啉-1,3-二酮类化合物的体外抗肿瘤活性和DNA插入作用。