7-hydroxyl-4,5-dihydrotetrazolo[1,5-a]quinolin | 1402548-93-9

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 7-hydroxyl-4,5-dihydrotetrazolo[1,5-a]quinolin
• 英文别名: 7-Hydroxyl-4,5-dihydrotetrazolo[1,5-a]quinoline；4,5-dihydrotetrazolo[1,5-a]quinolin-7-ol
• CAS: 1402548-93-9
• 化学式: C₉H₈N₄O
• 分子量: 188.189
• InChiKey: ZBGFVOOYBCMAGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-溴代庚烷 、 7-hydroxyl-4,5-dihydrotetrazolo[1,5-a]quinolin 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以85.5%的产率得到4,5-dihydro-7-heptyloxy-tetrazolo[1,5-a]quinoline
  参考文献：
  名称：

  Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives

  摘要：

  In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.

  DOI：

  10.1007/s00044-011-9922-8
• 作为产物：
  描述：

  6-(benzyloxy)-2-hydrazineylidene-1,2,3,4-tetrahydroquinoline 在 硫酸 、 palladium 10% on activated carbon 、 氢气 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 20.0~60.0 ℃ 、310.27 kPa 条件下， 反应 3.0h， 生成 7-hydroxyl-4,5-dihydrotetrazolo[1,5-a]quinolin
  参考文献：
  名称：

  Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives

  摘要：

  In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.

  DOI：

  10.1007/s00044-011-9922-8