5-benzenesulfonylacetyl-4-methyl-2-phenylthiazole | 300357-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-benzenesulfonylacetyl-4-methyl-2-phenylthiazole
• 英文别名: 1-(4-Methyl-2-phenyl-1,3-thiazol-5-yl)-2-(phenylsulfonyl)-1-ethanone；2-(benzenesulfonyl)-1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethanone
• CAS: 300357-23-7
• 化学式: C₁₈H₁₅NO₃S₂
• 分子量: 357.454
• InChiKey: VZHQYOARNLYJTO-UHFFFAOYSA-N

物化性质

• 沸点：
  603.2±65.0 °C(Predicted)
• 密度：
  1.317±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  氯化重氮苯 、 5-benzenesulfonylacetyl-4-methyl-2-phenylthiazole 在 sodium acetate 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 (2Z)-2-(benzenesulfonyl)-1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-2-(phenylhydrazinylidene)ethanone
  参考文献：
  名称：

  REACTIONS WITH HYDRAZONOYL HALIDES XXII: SYNTHESIS OF PYRROLO[3,4-C]PYRZOLINE, PYRAZOLINE PYRAZOLE, AND 2,3-DIHYDRO- 1,3,4-THIADIAZOLE DERIVATIVES

  摘要：

  5-Bromoacetyl-4-methyl-2-phenylthiazole reacted with dimethylsulfide, potassium thiocyanate, sodium benzenesulfinate and thiourea to afford products 2-5, respectively. Hydrazonoyl bromides 7a-c obtained via reaction N-nitrosoarylacetamides with sulfonium bromide 2. Hydrazonoyl bromides were used in synthesis of pyrrolidinopyrazolione, pyrazole, triazoline, thiadiazoline and 5-arylazothiazole derivatives. The structure of the newly synthesized compounds were confirmed on the basis of spectral, analytical analyses and alternative route whenever possible.

  DOI：

  10.1080/10426500008044992
• 作为产物：
  描述：

  2-溴-1-(4-甲基-2-苯基-1,3-噻唑-5-基)-1-乙酮 、 sodium benzenesulfonate 以 乙醇 为溶剂， 反应 1.0h， 以85%的产率得到5-benzenesulfonylacetyl-4-methyl-2-phenylthiazole
  参考文献：
  名称：

  REACTIONS WITH HYDRAZONOYL HALIDES XXII: SYNTHESIS OF PYRROLO[3,4-C]PYRZOLINE, PYRAZOLINE PYRAZOLE, AND 2,3-DIHYDRO- 1,3,4-THIADIAZOLE DERIVATIVES

  摘要：

  5-Bromoacetyl-4-methyl-2-phenylthiazole reacted with dimethylsulfide, potassium thiocyanate, sodium benzenesulfinate and thiourea to afford products 2-5, respectively. Hydrazonoyl bromides 7a-c obtained via reaction N-nitrosoarylacetamides with sulfonium bromide 2. Hydrazonoyl bromides were used in synthesis of pyrrolidinopyrazolione, pyrazole, triazoline, thiadiazoline and 5-arylazothiazole derivatives. The structure of the newly synthesized compounds were confirmed on the basis of spectral, analytical analyses and alternative route whenever possible.

  DOI：

  10.1080/10426500008044992

文献信息

• REACTIONS WITH HYDRAZONOYL HALIDES XXII: SYNTHESIS OF PYRROLO[3,4-C]PYRZOLINE, PYRAZOLINE PYRAZOLE, AND 2,3-DIHYDRO- 1,3,4-THIADIAZOLE DERIVATIVES
  作者：Abdou O. Abdelhamid、Nosrat M. Abed、Fyza M. Al-fayez

  DOI：10.1080/10426500008044992

  日期：2000.1

  5-Bromoacetyl-4-methyl-2-phenylthiazole reacted with dimethylsulfide, potassium thiocyanate, sodium benzenesulfinate and thiourea to afford products 2-5, respectively. Hydrazonoyl bromides 7a-c obtained via reaction N-nitrosoarylacetamides with sulfonium bromide 2. Hydrazonoyl bromides were used in synthesis of pyrrolidinopyrazolione, pyrazole, triazoline, thiadiazoline and 5-arylazothiazole derivatives. The structure of the newly synthesized compounds were confirmed on the basis of spectral, analytical analyses and alternative route whenever possible.