N-(4-chlorophenyl)-5-[(4-chlorophenyl)methyl]-1,3-thiazol-2-amine | 330567-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chlorophenyl)-5-[(4-chlorophenyl)methyl]-1,3-thiazol-2-amine
• CAS: 330567-51-6
• 化学式: C₁₆H₁₂Cl₂N₂S
• 分子量: 335.257
• InChiKey: ZEOSHTWSNOBZGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  p-chlorobenzenediazonium chloride 在 copper dichloride 作用下， 以 乙醇 、 水 、 丙酮 为溶剂， 反应 3.0h， 生成 N-(4-chlorophenyl)-5-[(4-chlorophenyl)methyl]-1,3-thiazol-2-amine
  参考文献：
  名称：

  Synthesis of heterocycles on the basis of products of arylation of unsaturated compounds 22.* 3-Aryl-2-chloropropanal in the synthesis of N-Aryl-5-(R-benzyl)-1,3-thiazole-2-amines

  摘要：

  3-Aryl-2-chloropropanal was obtained by the reaction of arenediazonium chlorides with acrolein in the presence of copper(II) chloride. N-Aryl(2-pyridyl)-5-(R-benzyl)-1,3-thiazole-2-amines were formed in high yield by the reaction of these aldehydes with aryl-and 2-pyridylthioureas. The same compounds were obtained by the reaction of 5-(R-benzyl)-1,3-thiazole-2-amines with aniline.

  DOI：

  10.1007/s10593-010-0537-7

文献信息

• Synthesis of heterocycles on the basis of products of arylation of unsaturated compounds 22.* 3-Aryl-2-chloropropanal in the synthesis of N-Aryl-5-(R-benzyl)-1,3-thiazole-2-amines
  作者：V. S. Matiychuk、N. D.Obushak、N. I. Pidlypnyi、Yu. V. Ostapiuk、R. M. Voloshchuk

  DOI：10.1007/s10593-010-0537-7

  日期：2010.8

  3-Aryl-2-chloropropanal was obtained by the reaction of arenediazonium chlorides with acrolein in the presence of copper(II) chloride. N-Aryl(2-pyridyl)-5-(R-benzyl)-1,3-thiazole-2-amines were formed in high yield by the reaction of these aldehydes with aryl-and 2-pyridylthioureas. The same compounds were obtained by the reaction of 5-(R-benzyl)-1,3-thiazole-2-amines with aniline.