bromoacetic-2,2-d2 acid bromoanhydride | 40897-88-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: bromoacetic-2,2-d2 acid bromoanhydride
• 英文别名: bromoacetyl bromide-d₂；2,2-d2-bromoacetyl bromide；bromoacetyl bromide-d2；Bromacetylbromid-d(2)；2-Bromoacetyl bromide-D2；2-bromo-2,2-dideuterioacetyl bromide
• CAS: 40897-88-9
• 化学式: C₂H₂Br₂O
• 分子量: 203.829
• InChiKey: LSTRKXWIZZZYAS-DICFDUPASA-N

物化性质

• 沸点：
  147-149 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  bromoacetic-2,2-d2 acid bromoanhydride 生成
  参考文献：
  名称：

  Production of Halomethylenes in Free-Jet Expansions from a Hot Nozzle: Identification and Characterization of HCBr and DCBr by Laser-Induced Fluorescence Excitation Spectroscopy

  摘要：

  The efficient production of chloromethylene and bromomethylene by hot-nozzle pyrolysis and subsequent supersonic free-jet expansion has been demonstrated. In the case of the bromocarbene, the LIF-excitation spectral measurements represent the first direct observations of this species. Visible spectra for both HCBr and DCBr have been obtained and are in accord with expectations for a species with nonlinear ground-state and quasilinear excited-state geometries. For the protonated species the excited-state bending frequency is near 840 cm-1 when v2 = 5 and the C-Br stretching frequency is nu3 almost-equal-to 783 cm-1.

  DOI：

  10.1021/j100062a008
• 作为产物：
  描述：

  乙酸-D3 在 溴 作用下， 生成 bromoacetic-2,2-d2 acid bromoanhydride
  参考文献：
  名称：

  Isomerization in ion pairs during solvolysis

  摘要：

  DOI：

  10.1007/bf01168278

文献信息

• Isomerization in ion pairs during solvolysis
  作者：T. A. Smolina、G. P. Brusova、L. F. Shchekut'eva、E. D. Gopius、A. B. Permin、O. A. Reutov

  DOI：10.1007/bf01168278

  日期：1980.9
• Esterified Dendritic TAM Radicals with Very High Stability and Enhanced Oxygen Sensitivity
  作者：Yuguang Song、Yangping Liu、Craig Hemann、Frederick A. Villamena、Jay L. Zweier

  DOI：10.1021/jo301849k

  日期：2013.2.15

  In this work, we have developed a new class of dendritic TAM radicals (TG, TdG, and dTdG) through a convergent method based on the TAM core CT-03 or its deuterated analogue dCT-03 and trifurcated Newkome-type monomer. Among these radicals, dTdG exhibits the best EPR properties with sharpest EPR singlet and highest O-2 sensitivity due to deuteration of both the ester linker groups and the TAM core CT-03. Like the previous dendritic TAM radicals, these new compounds also show extremely high stability toward various reactive species owing to the dendritic encapsulation. The highly charged nature of these molecules resulting from nine carboxylate groups prevents concentration-dependent EPR line broadening at physiological pH. Furthermore, we demonstrate that these TAM radicals can be easily derivatized (e.g., PEGylation) at the nine carboxylate groups and the resulting PEGylated analogue dTdG PEG completely inhibits the albumin binding, thereby enhancing suitability for in vivo applications. These new dendritic TAM radicals show great potential for in vivo EPR oximetric applications and provide insights on approaches to develop improved and targeted EPR oximetric probes for biomedical applications.
• Investigation of trifluoroacetolysis of some 2-bromoethanol arylsulfonates
  作者：E. D. Gopius、T. A. Smokina、M. L. Karpyuk、O. A. Reumov

  DOI：10.1007/bf00959376

  日期：1987.2
• Trifluoroacetolysis of 2-bromoethyl-2,2-d2 nosylate
  作者：T. A. Smolina、E. D. Gopius、A. R. Gromov、R. D. Rakhimov、O. A. Reutov

  DOI：10.1007/bf00956506

  日期：1984.7
• TALANOVA, M. YU.;GOPIUS, E. D.;SMOLINA, T. A.;REUTOV, O. A., BECTH. MGU. CEP. 2, 31,(1990) N, S. 320-321
  作者：TALANOVA, M. YU.、GOPIUS, E. D.、SMOLINA, T. A.、REUTOV, O. A.

  DOI：——

  日期：——