4-tert-butyl-oxazolidine-2,5-dione | 3981-38-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-tert-butyl-oxazolidine-2,5-dione
• 英文别名: (+/-)-4-tert-butyl-oxazolidine-2,5-dione；(+/-)-4-tert-Butyl-oxazolidin-2,5-dion；N-carboxy-tert-leucine anhydride；4-Tert-butyl-1,3-oxazolidine-2,5-dione
• CAS: 3981-38-2
• 化学式: C₇H₁₁NO₃
• mdl: MFCD24390819
• 分子量: 157.169
• InChiKey: GRDXOXRGSKKLNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-tert-butyl-oxazolidine-2,5-dione 以 乙醚 、 二氯甲烷 为溶剂， 反应 27.0h， 生成 N-acetyl-L-tert-leucine N'-methylamide
  参考文献：
  名称：

  Malon, Petr; Pancoska, Petr; Budesinsky, Milos, Collection of Czechoslovak Chemical Communications, 1983, vol. 48, # 10, p. 2844 - 2861

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-叔亮氨酸 在 alkaline solution 、 五氯化磷 、 氯甲酸苄酯 作用下， 生成 4-tert-butyl-oxazolidine-2,5-dione
  参考文献：
  名称：

  Izumiya et al., Journal of Biological Chemistry, 1953, vol. 205, p. 221,229

  摘要：

  DOI：

文献信息

• Amino acid-n-carboxy anhydrides hvaing substituent at nitrogen
  申请人：——

  公开号：US20020173664A1

  公开（公告）日：2002-11-21

  This invention provides amino acid N-carboxyanhydrides, each of which has an N-acyl substituent on its nitrogen atom, is represented by the following formula (1): 1 readily reacts with nucleophilic reagents such as free amino acids, alcohols, anions or the like, and are intermediates useful for the high-yield production of amino acid derivatives, optically active compounds, peptides, polypeptides and the like useful in many fields lead by the fields of pharmaceuticals and agrochemicals, and also provides a process for the production of the amino acid N-carboxyanhydrides. Further, the present invention also provides a process for the production of diamides, which uses the compounds of the formula (1) and amine derivatives represented by the following formula (7): 2 These diamides can also be suitably used for the production of amino acid derivatives, optically active compounds, peptides, polypeptides and the like.

  本发明提供了氨基酸N-羧酸酐，每个酐都在其氮原子上具有N-酰基取代基，由以下公式（1）表示：1可以与自由氨基酸、醇、阴离子等亲核试剂轻松反应，是用于高产率生产氨基酸衍生物、光学活性化合物、肽、多肽等在制药和农化领域等多个领域有用的中间体，并提供了一种制备氨基酸N-羧酸酐的方法。此外，本发明还提供了一种使用公式（1）所述化合物和以下公式（7）所表示的胺衍生物的二酰胺的制备方法：2这些二酰胺也可适用于生产氨基酸衍生物、光学活性化合物、肽、多肽等。
• SUBSTITUTED IMIDAZOHETEROCYCLE DERIVATIVES
  申请人：O'Connor Stephen J.

  公开号：US20120015930A1

  公开（公告）日：2012-01-19

  The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from —O—, —OCR g R h —, —CR g R h O—, —CR g R h —, —(CR g R h ) 2 —, —NR i —, —CR g R h NR i — and —NR i CR g R h —. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

  本发明提供了具有公式I的一般结构的取代咪唑杂环化合物，其中Y从—O—，—OCRgRh—，—CRgRhO—，—CRgRh—，—（CRgRh）2—，—NRi—，—CRgRhNRi—和—NRiCRgRh—中选择。此外，还提供了公式I化合物的药学上可接受的盐、酸盐、水合物、溶剂物和立体异构体。这些化合物可用作大麻素受体调节剂，并用于预防和治疗与大麻素受体相关的疾病和病症，例如疼痛、炎症和瘙痒。
• SUBSTITUTED IMIDAZOHETEROCYCLES
  申请人：Beckett R. Paul

  公开号：US20090149450A1

  公开（公告）日：2009-06-11

  The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

  本发明提供了具有公式I结构的取代咪唑杂环化合物，同时还提供了公式I化合物的药学上可接受的盐、酸盐、水合物、溶剂合物和立体异构体。该化合物可用作大麻素受体调节剂，并用于预防和治疗与大麻素受体相关的疾病和症状，例如疼痛、炎症和瘙痒等。
• AMINO ACID-N-CARBOXY ANHYDRIDES HVAING SUBSTITUENT AT NITROGEN
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1298127A1

  公开（公告）日：2003-04-02

  This invention provides amino acid N-carboxyanhydrides, each of which has an N-acyl substituent on its nitrogen atom, is represented by the following formula (1): readily reacts with nucleophilic reagents such as free amino acids, alcohols, anions or the like, and are intermediates useful for the high-yield production of amino acid derivatives, optically active compounds, peptides, polypeptides and the like useful in many fields lead by the fields of pharmaceuticals and agrochemicals, and also provides a process for the production of the amino acid N-carboxyanhydrides. Further, the present invention also provides a process for the production of diamides, which uses the compounds of the formula (1) and amine derivatives represented by the following formula (7): These diamides can also be suitably used for the production of amino acid derivatives, optically active compounds, peptides, polypeptides and the like.

  本发明提供了氨基酸 N-羧基酸酐，其中每个氨基酸的氮原子上都有一个 N-酰基取代基，由下式（1）表示： 本发明提供的氨基酸 N-羧基酸酐易于与亲核试剂（如游离氨基酸、醇、阴离子或类似物）反应，是高产生产氨基酸衍生物、光学活性化合物、肽、多肽等的中间体，可用于制药和农用化学品等多个领域，还提供了一种生产氨基酸 N-羧基酸酐的工艺。此外，本发明还提供了一种生产二酰胺的工艺，该工艺使用式（1）化合物和下式（7）代表的胺衍生物： 这些二酰胺还可用于生产氨基酸衍生物、光学活性化合物、肽、多肽等。
• Kricheldorf,H.R., Chemische Berichte, 1971, vol. 104, p. 3146 - 3155
  作者：Kricheldorf,H.R.

  DOI：——

  日期：——