N-Phenyl-N-(2-hydroxy-aethyl)-glycin | 20127-71-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Phenyl-N-(2-hydroxy-aethyl)-glycin
• 英文别名: 2-[N-(2-hydroxyethyl)anilino]acetic acid
• CAS: 20127-71-3
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: SPAZDZXTSLHKMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N-Phenyl-N-(2-hydroxy-aethyl)-glycin
  参考文献：
  名称：

  Kiprianow, Ukrains'kii Khemichnii Zhurnal, vol. 4, p. 231

  摘要：

  DOI：

文献信息

• Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer
  申请人：Hasumi Keiji

  公开号：US20090216028A1

  公开（公告）日：2009-08-27

  The present invention provides a triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R 1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R 4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R 5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.

  本发明提供了一种由以下化学式（II）和（III）所代表的三倍萜酚化合物，具有增强溶栓活性，以及一种高效制备该三倍萜酚化合物的方法。在化学式（II）和（III）中，R1代表芳香基团，其作为取代基或取代基的一部分至少包括羧基、羟基、磺酸基和二级氨基组成的群中的一种，或者是包含二级氨基并可能包含氮的芳香基团；在通式（III）中，R4代表由通式（III-1）所表示的芳香氨基酸残基；X代表—CHY—（CH3）2Z；Y和Z分别为—H或—OH或形成单键：（III-1）其中，R5代表可能存在或不存在的羟基；n代表0或1的整数。
• BICYCLIC HETEROCYCLIC COMPOUND
  申请人：Koga Yuji

  公开号：US20100113391A1

  公开（公告）日：2010-05-06

  [Problem] Provided is a compound, which exhibits a P2Y12 inhibitory action and is useful as a medical drug, particularly, as a platelet aggregation inhibitor. [Means for Solution] The inventors have eagerly investigated P2Y12 inhibitors. As a result, the inventors have found that a bicyclic heterocyclic compound such as quinazolinedione, isoquinolone, and the like having an amino group substituted with lower alkyl, cycloalkyl, or lower alkylene-cycloalkyl at the specific position exhibits an excellent platelet aggregation inhibitory action, thereby completing the present invention. Since the compound of the invention exhibits excellent P2Y12 inhibitory action and platelet aggregation inhibitory action, it is useful as a platelet aggregation inhibitor.

  [问题] 提供的是一种化合物，它表现出P2Y12抑制作用，可用作医药，特别是血小板聚集抑制剂。 [解决方法] 发明者们积极研究P2Y12抑制剂。结果，发明者们发现，具有氨基固定在特定位置的低烷基，环烷基或低烷基-环烷基的类似于喹唑啉二酮，异喹啉等的双环杂环化合物表现出优异的血小板聚集抑制作用，从而完成了本发明。由于本发明的化合物表现出优异的P2Y12抑制作用和血小板聚集抑制作用，因此它可用作血小板聚集抑制剂。
• TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER
  申请人：HASUMI Keiji

  公开号：US20120100579A1

  公开（公告）日：2012-04-26

  A triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R 1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R 4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH 3 ) 2 Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R 5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.

  以下为一种由式子（II）和（III）所代表的三倍半萜酚类化合物，具有促进溶血性的活性，以及一种高效的制备该三倍半萜酚类化合物的方法。在式子（II）和（III）中，R1代表一种芳香基团，其作为一个取代基或部分取代基，至少包含羧基、羟基、磺酸基和次级氨基中的一种，或者是包含次级氨基且可能包含氮的芳香基团；在一般式（III）中，R4代表由一般式（III-1）所表示的芳香氨基酸残基；X代表—CHY—（CH3）2Z；Y和Z分别代表—H或—OH，或者一起形成一个单键：（III-1）其中R5代表可能存在或不存在的羟基；n代表0或1的整数。
• PHOTOPOLYMERIZABLE COMPOSITION
  申请人：NIPPON PAINT CO., LTD.

  公开号：EP0522175A1

  公开（公告）日：1993-01-13

  A photopolymerizable composition comprising an ethylenically unsatured compound capable of addition polymerization and the following coloring matter (a) and polymerization initiator (b): (a): a compound of formula (I), wherein R₁ represents hydrogen, C₁ to C₃ alkyl, phenyl or halogen; R₂ represents methyl, ethyl or (CH₂)p-Q, wherein Q represents carboxyl, sulfonyl or a salt thereof, and p represents an integer of 1 to 4; X₁ and X₂ represent each independently -O-, -S, -CH=CH- or 〉N-R₂; Y₁ and Y₂ represent each independently hydrogen, C₁ to C₃ alkyl, C₁ to C₃ alkoxy, phenyl or halogen; Z represents -COO or -SO₃; m is 0 or 1; and n represents an integer of 1 to 4; (b); a diaryliodonium salt.

  一种可进行光聚合的组合物，它包含一种可进行加成聚合的乙烯基不成熟化合物， 以及下列着色剂(a)和聚合引发剂(b)式 (I) 的化合物，其中 R₁ 代表氢、C₁ 至 C₃ 烷基、苯基或卤素；R₂ 代表甲基、乙基或 (CH₂)p-Q，其中 Q 代表羧基、磺酰基或其盐，p 代表 1 至 4 的整数；X₁ 和 X₂ 各自独立地代表-O-、-S、-CH=CH- 或〉N-R₂； Y₁ 和 Y₂ 各自独立地代表氢、C₁ 至 C₃ 烷基、C₁ 至 C₃ 烷氧基、苯基或卤素；Z 代表-COO 或-SO₃；m 为 0 或 1；n 代表 1 至 4 的整数； (b); 二芳碘鎓盐。
• HOLOGRAM RECORDING MATERIAL
  申请人：NITTO DENKO CORPORATION

  公开号：EP1873593A1

  公开（公告）日：2008-01-02

  The present invention provides a hologram recording material which can modulate its refractive index effectively with visible light laser and is excellent also in transparency after this modulation. The present invention relates to a hologram recording material comprising a polymer (A) having a radically polymerizable side chain vinyl group in the molecule thereof, said polymer (A) being a polymer of monomers comprising as an essential component an acryl-vinyl monomer represented by the following formula (1): C⁢H2=CR1⁢C=O⁢O-R2=C⁢H2 wherein R1 represents a hydrogen atom or methyl group, and R2 represents a saturated or unsaturated hydrocarbon group having 1 to 20 carbon atoms, which may contain hetero atoms or halogen atoms in the molecule thereof; and a photopolymerization initiation source (B) which generates an active seed by visible light, and particularly relates to a hologram recording material having the aforementioned constitution in which the aforementioned photopolymerization initiation source (B) is a photopolymerization initiator which absorbs visible light to generate an active seed or a mixture of visible light-sensitizing dye and photopolymerization initiator.

  本发明提供了一种全息图记录材料，它可以用可见光激光有效地调节其折射率，并且在调节后透明度极佳。本发明涉及一种全息图记录材料，它包括一种聚合物（A），其分子中具有可辐射聚合的侧链乙烯基，所述聚合物（A）是一种单体聚合物，其基本成分包括由下式（1）表示的丙烯酰乙烯基单体：C⁢H2=CR1⁢C=O⁢O-R2=C⁢H2 其中 R1 代表氢原子或甲基，R2 代表具有 1 至 20 个碳原子的饱和或不饱和烃基，其分子中可含有杂原子或卤素原子；以及通过可见光产生活性种子的光聚合引发源 (B)，尤其涉及具有上述结构的全息图记录材料，其中上述光聚合引发源 (B) 是吸收可见光产生活性种子的光聚合引发剂或可见光敏化染料和光聚合引发剂的混合物。