2-methyl-6-hepten-1-ol | 67133-86-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methyl-6-hepten-1-ol
• 英文别名: 2-methylhept-6-en-1-ol；2-methyl-hept-6-en-1-ol；6-Hepten-1-ol, 2-methyl-
• CAS: 67133-86-2
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: UVGLIWCAMUOQPL-UHFFFAOYSA-N

物化性质

• 保留指数：
  994

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-溴-1-戊烯 在 lithium aluminium tetrahydride 、 sodium 、 三氟甲烷磺酸亚铜(I)苯联合体 (2:1) 、 sodium hydride 作用下， 以 乙醇 为溶剂， 反应 34.0h， 生成 2-methyl-6-hepten-1-ol
  参考文献：
  名称：

  Copper(I) catalysis of olefin photoreactions. 9. Photobicyclization of .alpha.-, .beta.-, and .gamma.-alkenylallyl alcohols

  摘要：

  DOI：

  10.1021/ja00368a014

文献信息

• Flexibly labeling peptides
  申请人：Pagel D. Mark

  公开号：US20080089842A1

  公开（公告）日：2008-04-17

  A solid phase peptide synthesis method for synthesizing a peptidyl contrast agent is disclosed. In one example, the method includes synthesizing an amino-chelator loaded resin, coupling of the amino-chelator loaded resin to the C-terminus and/or backbone of a peptide, cleaving the amino-chelator-peptide from a resin, and chelating a lanthanide metal to the amino-chelator-peptide.

  揭示了一种用于合成肽类对比剂的固相肽合成方法。在一个示例中，该方法包括合成氨基螯合物负载树脂，将氨基螯合物负载树脂偶联到肽的C-末端和/或骨架上，从树脂中裂解氨基螯合物-肽，并将镧系金属螯合到氨基螯合物-肽上。
• Total synthesis of optically active integerrimine, a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type
  作者：Haruki Niwa、Yasuyoshi Miyachi、Osamu Okamoto、Youichi Uosaki、Akio Kuroda、Hiroyuki Ishiwata、Kiyoyuki Yamada

  DOI：10.1016/s0040-4020(01)89003-7

  日期：——

  A total synthesis of the natural enantiomer of integerrimine (1), a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type has been achieved through the enantioselective synthesis and regioselective coupling of (+)-retronecine (4) and (+)-integerrinecic acid (methylthio)methyl ether (6).

  千里光的自然对映体（的总合成1 retronecine（ - ），retronecine类型的12元dilactonic吡咯烷类生物碱已经通过对映选择性合成和（+）的区域选择性耦合实现4）和（+） - integerrinecic酸（甲硫基）甲醚（6）。
• Polymeric Alkoxyalkylaluminum Compounds by Novel Reductive Cleavage of Saturated Cyclic Ethers. A New Organometallic Reagent in Organic Synthesis
  作者：Mitsuhiro Sumitani、Kazuhiko Kanemitsuya、Hajime Yasuda、Hisaya Tani

  DOI：10.1246/bcsj.51.1511

  日期：1978.5

  the C–O–C bond of saturated cyclic ethers by the HgCl2–ZnCl2–MeI catalyst system led to the reductive cleavage of 5, 6, and 7 membered ring ethers to give polymeric alkoxyalkylaluminum compounds. The relative rate of the reaction was increased in the order of tetrahydrofuran, 3-methyltetrahydrofuran, 2-methyltetrahydrofuran, 2,5-dimethyltetrahydrofuran, tetrahydropyran, oxepane, 7-oxabicyclo[2.2.1]-heptane

  通过 HgCl2-ZnCl2-MeI 催化剂体系将铝插入饱和环醚的 C-O-C 键导致 5、6 和 7 元环醚的还原裂解，得到聚合烷氧基烷基铝化合物。反应的相对速率按四氢呋喃、3-甲基四氢呋喃、2-甲基四氢呋喃、2,5-二甲基四氢呋喃、四氢吡喃、氧杂环己烷、7-氧杂双环[2.2.1]-庚烷和2-甲基四氢吡喃的顺序增加。裂解的环醚与铝原子双官能键合，所得聚合铝化合物在氘化时得到双氘醇。烯丙基卤与铝化合物的加成反应和氯醛的还原为制备不饱和醇提供了一条新途径。
• EPOTHILONE DERIVATIVES
  申请人：Vite D. Gregory

  公开号：US20070255055A1

  公开（公告）日：2007-11-01

  The present invention relates to compounds of the formula Q is selected from the group consisting of G is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo, W is O or NR 15 ; X is O or H,H; Y is selected from the group consisting of O; H,OR 16 ; OR 17 ,OR 17 ; NOR 18 ; H,NOR 19 ; H,NR 20 R 21 ; H,H; or CHR 22 ; OR 17 OR 17 can be a cyclic ketal; Z 1 and Z 2 are selected from the group consisting of CH 2 , O, NR 23 , S, or SO 2 , wherein only one of Z and Z 2 is a heteroatom; B 1 and B 2 are selected from the group consisting of OR 24 , or OCOR 25 , or O 2 CNR 26 R 27 ; when B 1 is H and Y is OH, H they can form a six-membered ring ketal or acetal; D is selected from the group consisting of NR 28 R 29 , NR 30 COR 31 or saturated heterocycle; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 13 , R 14 , R 18 , R 19 , R 20 , R 21 , R 22 , R 26 , and R 27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R 1 and R 2 are alkyl can be joined to form a cycloalkyl; R 3 and R 4 are alkyl can be joined to form a cycloalkyl; R 9 , R 10 , R 16 , R 17 , R 24 , R 25 , and R 31 are selected from the group H, alkyl, or substituted alkyl; R 8 , R 11 , R 12 , R 28 , R 30 , R 32 , R 33 , and R 30 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, or heterocyclo; R 15 , R 23 and R 29 are selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, heterocyclo, R 32 C═O, R 33 SO 2 , hydroxy, O-alkyl or O-substituted alkyl, the pharmaceutically acceptable salts thereof and any hydrates, solvates or geometric, optical and stereoisomers thereof, with the proviso that compounds wherein W and X are both O; and R 1 , R 2 , R 7 , are H; and R 3 , R 4 , R 6 , are methyl; and R 8 , is H or methyl; and Z 1 , and Z 2 , are CH 2 ; and G is 1-methyl-2-(substituted-4-thiazolyl)ethenyl; and Q is as defined above are excluded.

  本发明涉及以下化合物的公式：其中Q选自G选自烷基，取代烷基，取代或未取代芳基，杂环烷基，W为O或NR15；X为O或H；Y选自O，H，OR16，OR17，NOR18，H，NOR19，H，NR20R21，H，H或CHR22；OR17OR17可以是环状缩酮；Z1和Z2选自CH2，O，NR23，S或SO2，其中仅Z和Z2中的一个为杂原子；B1和B2选自OR24，或OCOR25，或O2CNR26R27；当B1为H且Y为OH时，它们可以形成六元环缩酮或缩醛；D选自NR28R29，NR30COR31或饱和杂环；R1，R2，R3，R4，R5，R6，R7，R13，R14，R18，R19，R20，R21，R22，R26和R27选自H，烷基，取代烷基或芳基，当R1和R2为烷基时，可以连接成环烷基；R3和R4为烷基时，可以连接成环烷基；R9，R10，R16，R17，R24，R25和R31选自H，烷基或取代烷基；R8，R11，R12，R28，R30，R32，R33和R30选自H，烷基，取代烷基，芳基，取代芳基，环烷基或杂环烷基；R15，R23和R29选自H，烷基，取代烷基，芳基，取代芳基，环烷基，杂环烷基，R32C═O，R33SO2，羟基，O-烷基或O-取代烷基，其药学上可接受的盐和任何水合物，溶剂化合物或其几何，光学和立体异构体，但其中W和X都是O；并且R1，R2，R7为H；并且R3，R4，R6为甲基；并且R8为H或甲基；并且Z1和Z2为CH2；并且G为1-甲基-2-（取代-4-噻唑基）乙烯基；并且Q如上所定义被排除在外。
• Epothilone derivatives
  申请人：Vite D. Gregory

  公开号：US20060287371A1

  公开（公告）日：2006-12-21

  The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B 1 , B 2 , Z 1 , Z 2 , and R 1 -R 7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.

  本发明涉及公式中的化合物，其中变量G、W、Q、X、Y、B1、B2、Z1、Z2和R1-R7的定义如本文所述，以及其衍生物和中间体的制备方法。