2-amino-4-(2,4-dichloro-phenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile | 582292-88-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-4-(2,4-dichloro-phenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile
• 英文别名: 2-amino-4-(2,4-dichlorophenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile
• CAS: 582292-88-4
• 化学式: C₁₉H₁₁Cl₂N₃
• 分子量: 352.222
• InChiKey: QOBPIIXWXXUILO-UHFFFAOYSA-N

物化性质

• 沸点：
  569.6±50.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-4-(2,4-dichloro-phenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以67%的产率得到3-Aminomethyl-4-(2,4-dichloro-phenyl)-5H-indeno[1,2-b]pyridin-2-ylamine
  参考文献：
  名称：

  Aminomethylpyridines as DPP-IV inhibitors

  摘要：

  In a novel series of DPP-IV inhibitors, a large increase of inhibitory activity was achieved by optimisation of aromatic substituents and conformational restriction. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.049
• 作为产物：
  描述：

  2-[(2,4-二氯苯基)亚甲基]丙二腈 、 1-茚酮 在 ammonium acetate 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以18%的产率得到2-amino-4-(2,4-dichloro-phenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile
  参考文献：
  名称：

  Aminomethylpyridines as DPP-IV inhibitors

  摘要：

  In a novel series of DPP-IV inhibitors, a large increase of inhibitory activity was achieved by optimisation of aromatic substituents and conformational restriction. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.049

文献信息

• Pyridine and quinoline derivatives
  申请人：——

  公开号：US20030195188A1

  公开（公告）日：2003-10-16

  The present invention provides compounds of formula (I) 1 wherein R 1 , R 2 , R 3 and R 4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.

  本发明提供了公式（I）1的化合物，其中R1，R2，R3和R4如规范中所定义，并且其药学上可接受的盐。这些化合物对于治疗和/或预防与DPP IV相关的疾病非常有用，例如糖尿病，特别是非胰岛素依赖性糖尿病和糖耐量受损。
• NOVEL PYRIDINE- AND QUINOLINE-DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1476429A1

  公开（公告）日：2004-11-17
• US6800650B2
  申请人：——

  公开号：US6800650B2

  公开（公告）日：2004-10-05
• [EN] NOVEL PYRIDINE- AND QUINOLINE-DERIVATIVES<br/>[FR] NOUVEAUX DERIVES DE PYRIDINE ET DE QUINOLINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2003068748A1

  公开（公告）日：2003-08-21

  The present invention relates to compounds of formula (I), wherein Rl, R2, R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
• Aminomethylpyridines as DPP-IV inhibitors
  作者：Jens-Uwe Peters、Silja Weber、Stéphane Kritter、Peter Weiss、Angelina Wallier、Daniel Zimmerli、Markus Boehringer、Matthias Steger、Bernd-Michael Loeffler

  DOI：10.1016/j.bmcl.2004.04.049

  日期：2004.7

  In a novel series of DPP-IV inhibitors, a large increase of inhibitory activity was achieved by optimisation of aromatic substituents and conformational restriction. (C) 2004 Elsevier Ltd. All rights reserved.