glutathione hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: glutathione hydrochloride
• 英文别名: H-gGlu-Cys-Gly-OH.HCl；(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid;hydrochloride
• 化学式: C₁₀H₁₇N₃O₆S*ClH
• 分子量: 343.788
• InChiKey: VOXZROYPJOCCFH-GEMLJDPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.78
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  160
• 氢给体数：
  7
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4-氟-alpha,alpha-二苯基苯甲醇 、 glutathione hydrochloride 生成 (S)-2-Amino-4-{(R)-1-(carboxymethyl-carbamoyl)-2-[(4-fluoro-phenyl)-diphenyl-methylsulfanyl]-ethylcarbamoyl}-butyric acid
  参考文献：
  名称：

  实验性抗白血病药物。S-三苯甲基半胱氨酸及相关化合物的制备及结构活性研究。

  摘要：

  DOI：

  10.1021/jm00297a019

文献信息

• Compositions for potentiating glutatthione
  申请人：Chiba Tomohiro

  公开号：US20060257351A1

  公开（公告）日：2006-11-16

  A composition for potentiating glutathione, which contains at least one member selected from the group consisting of 2-(3,4-dihydroxyphenyl)ethanol or a glycoside thereof, a plant containing 2-(3,4-dihydroxyphenyl)ethanol or a glycoside thereof, an extract of said plant, a hydrolysate of said plant, and a hydrolysate of the extract of said plant (excluding Olea europaea and an extract thereof), and which further contains at least one member selected from among an S-containing compound that is a supply source of cysteine, a protein that contains cysteine and/or cystine, a yeast that contains cysteine and/or cystine, and a vitamin.

  一种用于增强谷胱甘肽作用的组合物，包含至少从以下组合中选择的一种成员：2-(3,4-二羟基苯基)乙醇或其糖苷，含有2-(3,4-二羟基苯基)乙醇或其糖苷的植物，该植物的提取物，该植物的水解产物，以及该植物提取物的水解产物（不包括欧洲橄榄和其提取物），并且进一步包含至少从以下成员中选择的一种：供应半胱氨酸的含硫化合物，含有半胱氨酸和/或半胱氨酸的蛋白质，含有半胱氨酸和/或半胱氨酸的酵母，以及维生素。
• [EN] COMPOUNDS FOR TREATING NEURODEGENERATIVE DISORDERS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：ETHNODYNE

  公开号：WO2019116069A1

  公开（公告）日：2019-06-20

  The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.

  本发明涉及式（I）的化合物，其合成方法以及它们用于治疗神经退行性疾病的用途。
• DERMATOLOGIC PREPARATION
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0976381A1

  公开（公告）日：2000-02-02

  A dermatologic preparation characterized by containing a thiol compound and zinc oxide. By combining the thiol compound with zinc oxide, the thiol compound can be stably compounded in the preparation.

  一种皮肤科制剂，其特征在于含有硫醇化合物和氧化锌。通过将硫醇化合物与氧化锌结合，硫醇化合物可以稳定地复合在制剂中。
• COMPOSITIONS FOR EXTERNAL USE
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1145707A1

  公开（公告）日：2001-10-17

  Compositions for external use which contain a zinc compound, in particular, a composition for external use which contains a zinc compound and a thiol compound and a composition for external use which contains a higher fatty acid zinc salt as the zinc compounds and a polar oil derivative having an I.O.B. value of 0.1 or more. These compositions can promote the production of metallothionein in skin cells and thus prevent skin damage due to solar UV light, etc. without any problem of odor.

  含有锌化合物的外用组合物，特别是含有锌化合物和硫醇化合物的外用组合物，以及含有作为锌化合物的高脂肪酸锌盐和 I.O.B. 值为 0.1 或以上的极性油衍生物的外用组合物。这些组合物可以促进皮肤细胞中金属硫蛋白的生成，从而防止因太阳紫外线等造成的皮肤损伤，而且不会产生任何异味。
• Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
  申请人：Merial Inc.

  公开号：US10080791B2

  公开（公告）日：2018-09-25

  The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.

  本发明涉及用于灭活微生物和病毒同时保留其免疫原性的高压氧装置，以及用于从原核细胞或真核细胞产生的包涵体中制造和生产可溶性、分解的、重新折叠的或有活性的免疫原性或治疗性蛋白质的高压氧装置。本发明包括高压灭活病原体的方法，以及使用灭活病原体生产疫苗组合物的方法。高压灭活微生物比化学灭活微生物更安全，免疫原性更高。同样，溶解的蛋白质与聚集程度较高的蛋白质相比具有更优越的特性，包括减少非特异性免疫反应。