2-[4-(2-amino-5-tert-butylphenyl)phenyl]-4-tert-butylaniline | 1276656-62-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(2-amino-5-tert-butylphenyl)phenyl]-4-tert-butylaniline
• CAS: 1276656-62-2
• 化学式: C₂₆H₃₂N₂
• 分子量: 372.553
• InChiKey: CCSAGNYTVIWPIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[4-(2-amino-5-tert-butylphenyl)phenyl]-4-tert-butylaniline 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Synthetic Mimics of Antimicrobial Peptides from Triaryl Scaffolds

  摘要：

  In this report, we describe the synthesis of a new series of small amphiphilic aromatic compounds that mimic the essential properties of cationic antimicrobial peptides using Suzuki-Miyaura coupling. The new design allowed the easy tuning of the conformational restriction, controlled by introduction of intramolecular hydrogen bonds, and the overall hydrophobicity by modifications to the central ring and the side chains. This approach allowed us to better understand the influence of these features on the antimicrobial. activity and selectivity. We found that the overall hydrophobicity had a more significant impact on antimicrobial and hemolytic activity than the conformational stiffness. A novel compound was discovered which has MICs of 0.78 mu g/mL against S. Aureus and 6.25 mu g/mL against E. Coli, similar to the well-known antimicrobial peptide, MSI-78.

  DOI：

  10.1021/jm101410t
• 作为产物：
  描述：

  2-溴-4-叔丁基苯胺 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 sodium carbonate 、 三乙胺 作用下， 以 1,4-二氧六环 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 2-[4-(2-amino-5-tert-butylphenyl)phenyl]-4-tert-butylaniline
  参考文献：
  名称：

  Synthetic Mimics of Antimicrobial Peptides from Triaryl Scaffolds

  摘要：

  In this report, we describe the synthesis of a new series of small amphiphilic aromatic compounds that mimic the essential properties of cationic antimicrobial peptides using Suzuki-Miyaura coupling. The new design allowed the easy tuning of the conformational restriction, controlled by introduction of intramolecular hydrogen bonds, and the overall hydrophobicity by modifications to the central ring and the side chains. This approach allowed us to better understand the influence of these features on the antimicrobial. activity and selectivity. We found that the overall hydrophobicity had a more significant impact on antimicrobial and hemolytic activity than the conformational stiffness. A novel compound was discovered which has MICs of 0.78 mu g/mL against S. Aureus and 6.25 mu g/mL against E. Coli, similar to the well-known antimicrobial peptide, MSI-78.

  DOI：

  10.1021/jm101410t

文献信息

• Synthetic Mimics of Antimicrobial Peptides from Triaryl Scaffolds
  作者：Hitesh D. Thaker、Federica Sgolastra、Dylan Clements、Richard W. Scott、Gregory N. Tew

  DOI：10.1021/jm101410t

  日期：2011.4.14

  In this report, we describe the synthesis of a new series of small amphiphilic aromatic compounds that mimic the essential properties of cationic antimicrobial peptides using Suzuki-Miyaura coupling. The new design allowed the easy tuning of the conformational restriction, controlled by introduction of intramolecular hydrogen bonds, and the overall hydrophobicity by modifications to the central ring and the side chains. This approach allowed us to better understand the influence of these features on the antimicrobial. activity and selectivity. We found that the overall hydrophobicity had a more significant impact on antimicrobial and hemolytic activity than the conformational stiffness. A novel compound was discovered which has MICs of 0.78 mu g/mL against S. Aureus and 6.25 mu g/mL against E. Coli, similar to the well-known antimicrobial peptide, MSI-78.