N-[3-[benzoyl(ethyl)amino]propyl]-N-ethylbenzamide | 82126-38-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-[benzoyl(ethyl)amino]propyl]-N-ethylbenzamide
• CAS: 82126-38-3
• 化学式: C₂₁H₂₆N₂O₂
• 分子量: 338.45
• InChiKey: GGQHAJYZQXFSBX-UHFFFAOYSA-N

物化性质

• 沸点：
  526.7±33.0 °C(Predicted)
• 密度：
  1.090±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二(二甲氨基)二甲基硅 在 氢氟酸 作用下， 反应 1.0h， 生成 N-[3-[benzoyl(ethyl)amino]propyl]-N-ethylbenzamide
  参考文献：
  名称：

  含硅衍生物的合成：对称二胺的非对称衍生

  摘要：

  描述了通过使用环状硅氮化合物作为中间体将对称的二胺转化为单酰胺。

  DOI：

  10.1016/s0040-4039(00)86999-3

文献信息

• Selective Monoacylation of Symmetrical Diamines via Prior Complexation with Boron
  作者：Zhongxing Zhang、Zhiwei Yin、Nicholas A. Meanwell、John F. Kadow、Tao Wang

  DOI：10.1021/ol0300773

  日期：2003.9.1

  [reaction: see text] Pretreatment of a symmetrical primary or secondary diamine with 9-BBN prior to the addition of an acyl chloride significantly suppressed undesired diacylation, and the product of monoacylation predominated. The reactive preference is interpreted as the result of a selective deactivation of one nitrogen atom of the diamine by 9-BBN.

  [反应：见正文]在添加酰氯之前，用9-BBN预处理对称的伯或仲二胺会显着抑制不希望的二酰化作用，并且单酰化产物占主导地位。反应性偏爱被解释为二胺的一个氮原子被9-BBN选择性失活的结果。
• Imidazole-Catalyzed Monoacylation of Symmetrical Diamines
  作者：Sanjeev K. Verma、B. N. Acharya、M. P. Kaushik

  DOI：10.1021/ol101604q

  日期：2010.10.1

  An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.

  已经开发了咪唑催化的对称二胺单酰基化方案。该方案给出了脂族（环状和无环）伯和仲二胺的选择性单酰化作用。在反应中，咪唑既充当催化剂又充当离去基团。在乙醇/水溶剂体系中，在室温下合成了不同的单酰化哌嗪和其他二胺。
• SCHWARTZ, E.;SHANZER, A., TETRAHEDRON LETT., 1982, 23, N 9, 979-982
  作者：SCHWARTZ, E.、SHANZER, A.

  DOI：——

  日期：——
• Antimicrobial Compositions
  申请人：Alberte Randall S.

  公开号：US20090016990A1

  公开（公告）日：2009-01-15

  The present invention relates in part to a composition comprising a compound of Formula I or Formula II and at least one other antimicrobial agent. The invention also relates in part to a pharmaceutical composition comprising the composition of claim 1 and a pharmaceutically acceptable carrier or excipient. The invention further relates in part to a method of treating a subject with a microbial illness comprising administering to a subject in need thereof the aforementioned pharmaceutical composition. The invention further relates in part to a method of disinfecting a surface comprising administering to the surface the aforementioned a composition. The invention also relates in part to a coating comprising the aforementioned composition.
• Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins
  申请人：Alberte Randall S.

  公开号：US20090124690A1

  公开（公告）日：2009-05-14

  The present invention relates to, in part, novel sulfate and bisphenol compounds useful for the recognition, attachment and growth of unwanted biologics on natural and manmade surfaces. Another aspect of the invention relates to combinatorial libraries for producing the same. Another aspect of the invention relates to pharmaceutical formulations comprising the same.