[16-(t-butyldimethylsilanyloxy)hexadecyl]-(2,5-dimethoxyphenyl)amine | 907218-97-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [16-(t-butyldimethylsilanyloxy)hexadecyl]-(2,5-dimethoxyphenyl)amine
• 英文别名: N-[16-[tert-butyl(dimethyl)silyl]oxyhexadecyl]-2,5-dimethoxyaniline
• CAS: 907218-97-7
• 化学式: C₃₀H₅₇NO₃Si
• 分子量: 507.873
• InChiKey: YGKBWTGZOPGLPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  35
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  39.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [16-(t-butyldimethylsilanyloxy)hexadecyl]-(2,5-dimethoxyphenyl)amine 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以81%的产率得到16-(2,5-dimethoxyphenylamino)hexadecan-1-ol
  参考文献：
  名称：

  EP1854777

  摘要：

  公开号：
• 作为产物：
  描述：

  16-溴-1-十六烷醇 在 咪唑 、 正丁基锂 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 [16-(t-butyldimethylsilanyloxy)hexadecyl]-(2,5-dimethoxyphenyl)amine
  参考文献：
  名称：

  Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth

  摘要：

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.027

文献信息

• Hydroquinone Long-Chain Derivative and/or Phenoxy Long-Chain Derivative and Pharmaceutical Comprising Same
  申请人：Luu Bang

  公开号：US20090036542A1

  公开（公告）日：2009-02-05

  The present invention provides compounds represented by formula (1) shown below: (wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each individually selected from among a hydrogen atom, methyl group, acetyl group, hydroxyl group, and alkoxy group; and X represents an alkylene group or alkenylene group); and compounds represented by formula (2) shown below: (wherein R 6 , R 7 , R 8 , R 9 , and R 10 are each individually selected from among a hydrogen atom, alkyl group, acetyl group, hydroxyl group, and alkoxy group; A represents an oxygen atom or NH, and m is 0 or 1; and Y represents an alkylene group or alkenylene group, and Z represents a hydrogen atom or hydroxyl group). The compounds of the present invention are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

  本发明提供以下式子（1）所示的化合物：（其中R1、R2、R3、R4和R5分别从氢原子、甲基基团、乙酰基团、羟基团和烷氧基中各自选择；X代表烷基或烯基）；以及以下式子（2）所示的化合物：（其中R6、R7、R8、R9和R10分别从氢原子、烷基、乙酰基团、羟基团和烷氧基中各自选择；A代表氧原子或NH，m为0或1；Y代表烷基或烯基，Z代表氢原子或羟基）。本发明的化合物对于预防或治疗由中枢神经系统或外周神经系统细胞的退化和/或丧失引起的脑功能障碍、运动功能障碍或尿功能障碍是有用的。
• Hydroquinone long-chain derivatives and/or phenoxy long-chain derivatives, and pharmaceuticals comprising the same
  申请人：Meiji Dairies Corporation

  公开号：US07893304B2

  公开（公告）日：2011-02-22

  The present invention provides compounds that are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.

  本发明提供了化合物，用于预防或治疗由中枢神经系统或外周神经系统细胞的退化和/或丢失引起的脑功能障碍、运动功能障碍或泌尿功能障碍。
• EP1854777
  申请人：——

  公开号：——

  公开（公告）日：——
• Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth
  作者：Mazen Hanbali、Dominique Bagnard、Bang Luu

  DOI：10.1016/j.bmcl.2006.05.027

  日期：2006.8

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.