(2-chloro-5-nitro-pyrimidin-4-yl)-[2]pyridyl-amine | 874494-90-3

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: (2-chloro-5-nitro-pyrimidin-4-yl)-[2]pyridyl-amine
• 英文别名: (2-Chlor-5-nitro-pyrimidin-4-yl)-[2]pyridyl-amin
• CAS: 874494-90-3
• 化学式: C₉H₆ClN₅O₂
• 分子量: 251.632
• InChiKey: ITAFBLAYGYWYLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.84
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (2-chloro-5-nitro-pyrimidin-4-yl)-[2]pyridyl-amine 在 甲醇 、 氨 作用下， 生成 5-nitro-N⁴-[2]pyridyl-pyrimidine-2,4-diyldiamine
  参考文献：
  名称：

  Psychological Adjustment to Sudden and Anticipated Spousal Loss Among Older Widowed Persons

  摘要：

  Objectives. This study examined if older adults' psychological adjustment to widowhood varies based on whether the death was sudden or anticipated and if these effects are mediated by death context characteristics (e.g., predeath care-giving, nursing home use. spouse's age at death, and couple's communication about the death).Methods. The effects of forewarning on multiple indicators of mental health and grief were examined in a sample 210 widowed persons who participated in the Changing Lives of Older Couples (CLOC) study. The CLOG is a probability sample of 1,532 married individuals aged 65 and older for whom baseline information was collected in 1987-881 with widowed persons reinterviewed 6, 18, and 48 months after spousal loss.Results. Forewarning did not affect depression. anger, shock, or overall grief 6 or 18 months after the loss. Prolonged forewarning was associated with elevated anxiety both 6 and 18 months after the death. Sudden spousal death elevated survivors intrusive thoughts at the 6-month follow-up only. Sudden death was associated with slightly higher levels of yearning among women but significantly lower yearning among men both 6 and 18 months after the loss.Discussion. The findings call into question the widespread belief that grief is moi e severe if death is sudden and suggest a more complex relationship between bereavement and circumstances of spousal death.

  DOI：

  10.1093/geronb/56.4.s237
• 作为产物：
  描述：

  2-氨基吡啶 、 2,4-二氯-5 硝基嘧啶 在 甲醇 作用下， 生成 (2-chloro-5-nitro-pyrimidin-4-yl)-[2]pyridyl-amine 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Psychological Adjustment to Sudden and Anticipated Spousal Loss Among Older Widowed Persons

  摘要：

  Objectives. This study examined if older adults' psychological adjustment to widowhood varies based on whether the death was sudden or anticipated and if these effects are mediated by death context characteristics (e.g., predeath care-giving, nursing home use. spouse's age at death, and couple's communication about the death).Methods. The effects of forewarning on multiple indicators of mental health and grief were examined in a sample 210 widowed persons who participated in the Changing Lives of Older Couples (CLOC) study. The CLOG is a probability sample of 1,532 married individuals aged 65 and older for whom baseline information was collected in 1987-881 with widowed persons reinterviewed 6, 18, and 48 months after spousal loss.Results. Forewarning did not affect depression. anger, shock, or overall grief 6 or 18 months after the loss. Prolonged forewarning was associated with elevated anxiety both 6 and 18 months after the death. Sudden spousal death elevated survivors intrusive thoughts at the 6-month follow-up only. Sudden death was associated with slightly higher levels of yearning among women but significantly lower yearning among men both 6 and 18 months after the loss.Discussion. The findings call into question the widespread belief that grief is moi e severe if death is sudden and suggest a more complex relationship between bereavement and circumstances of spousal death.

  DOI：

  10.1093/geronb/56.4.s237