(1-fluorovinyl) phenyl sulfoxide | 515863-85-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-fluorovinyl) phenyl sulfoxide
• 英文别名: [(1-Fluoroethenyl)sulfinyl]benzene；1-fluoroethenylsulfinylbenzene
• CAS: 515863-85-1
• 化学式: C₈H₇FOS
• 分子量: 170.207
• InChiKey: QZUXJNRNCJZQIN-UHFFFAOYSA-N

物化性质

• 沸点：
  319.9±17.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-二苯基异苯并呋喃 、 (1-fluorovinyl) phenyl sulfoxide 以 乙二醇 为溶剂， 反应 8.0h， 以49%的产率得到2-fluoro-1,4-diphenylnaphthalene
  参考文献：
  名称：

  （1-氟乙烯基）苯基亚砜作为亲二烯体的合成与反应性

  摘要：

  由（1-氟乙烯基）甲基二苯基硅烷分两步制备（1-氟代乙烯基）苯基亚砜2。尽管亚砜2与非常活泼的二烯1,3-二苯基异苯并呋喃进行了狄尔斯-阿尔德反应，仅一步就得到了相应的氟化萘衍生物，但它并没有与其他二烯一起提供环加合物。

  DOI：

  10.1016/s0022-1139(02)00198-7
• 作为产物：
  描述：

  S-苯基硫代苯基砜 在 间氯过氧苯甲酸 、 cesium fluoride 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 (1-fluorovinyl) phenyl sulfoxide
  参考文献：
  名称：

  （1-氟乙烯基）苯基亚砜作为亲二烯体的合成与反应性

  摘要：

  由（1-氟乙烯基）甲基二苯基硅烷分两步制备（1-氟代乙烯基）苯基亚砜2。尽管亚砜2与非常活泼的二烯1,3-二苯基异苯并呋喃进行了狄尔斯-阿尔德反应，仅一步就得到了相应的氟化萘衍生物，但它并没有与其他二烯一起提供环加合物。

  DOI：

  10.1016/s0022-1139(02)00198-7

文献信息

• 12-POSITION SUBSTITUTED MUTILIN DERIVATIVE
  申请人：KYORIN PHARMACEUTICAL CO., LTD.

  公开号：EP1832591A1

  公开（公告）日：2007-09-12

  A position 12-substituted mutilin derivative, a novel mutilin analogue, is provided that exhibits strong antimicrobial activity against a broad spectrum of Gram-positive or Gram-negative bacteria, including various drug-resistant bacteria, as well as intermediates for the production of such mutilin derivatives. Specifically, a mutilin derivative or an acid-addition salt thereof is provided that is represented by the following chemical formula (1): (wherein R1 is a hydrogen atom, a formyl group, a substituted or unsubstituted lower alkyl group, an aralkyl group whose aromatic ring may be optionally substituted, a heteroaralkyl group whose aromatic ring may be optionally substituted or a lower alkyloxycarbonyl group; and R2 is a hydrogen atom, a lower alkyl group or an aralkyl group whose aromatic ring may be optionally substituted) (R1 is neither an ethyl group nor a vinyl group).

  提供了一种位置12-取代的莫司林衍生物，一种新型莫司林类似物，对广谱的革兰氏阳性或阴性细菌，包括各种耐药细菌，表现出强大的抗微生物活性，以及用于生产这种莫司林衍生物的中间体。具体地，提供了一种莫司林衍生物或其酸盐加合物，其由以下化学式（1）表示：（其中R1是氢原子、甲酰基、取代或未取代的较低烷基基团、芳基烷基基团，其芳香环可能选择性取代、取代或未取代的杂芳烷基基团或较低烷氧羰基基团；R2是氢原子、较低烷基基团或其芳香环可能选择性取代的芳基烷基基团）（R1既不是乙基基团也不是乙烯基团）。
• Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
  申请人：Fukuda Yasumichi

  公开号：US20050038092A1

  公开（公告）日：2005-02-17

  This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobacterial species. The compounds are represented by structural formula I: its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.

  本发明涉及新的含有环丙基基团的噁唑烷酮，对于耐药性较强的革兰氏阳性菌（如多重耐药金黄色葡萄球菌、链球菌和肠球菌）、Bacteroides属、Clostridia属物种以及酸性快速生长菌（如结核分枝杆菌和其他分枝杆菌物种）等厌氧和需氧病原体具有良好的抗菌作用。所述化合物由结构式I表示，其对映异构体、不对称异构体或其药学上可接受的盐或酯。
• Stereoselective Synthesis of <i>cis</i>-2-Fluorocyclopropanecarboxylic Acid
  作者：Taku Shibue、Yasumichi Fukuda

  DOI：10.1021/jo501219n

  日期：2014.8.1

  A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopropanation of electron-deficient olefin and diazoacetates.
• CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF
  申请人：Merck & Co., Inc.

  公开号：EP1646629A2

  公开（公告）日：2006-04-19
• Mutilin-Derivative Substituted at Position 12
  申请人：Takadoi Masanori

  公开号：US20080221330A1

  公开（公告）日：2008-09-11

  A position 12-substituted mutilin derivative, a novel mutilin analogue, is provided that exhibits strong antimicrobial activity against abroad spectrum of Gram-positive or Gram-negative bacteria, including various drug-resistant bacteria, as well as intermediates for the production of such mutilin derivatives. Specifically, a mutilin derivative or an acid-addition salt thereof is provided that is represented by the following chemical formula (1): (wherein R 1 is a hydrogen atom, a formyl group, a substituted or unsubstituted lower alkyl group, an aralkyl group whose aromatic ring may be optionally substituted, a heteroaralkyl group whose aromatic ring may be optionally substituted or a lower alkyloxycarbonyl group; and R 2 is a hydrogen atom, a lower alkyl group or an aralkyl group whose aromatic ring may be optionally substituted) (R 1 is neither an ethyl group nor a vinyl group).