1-benzyloxy-5E-dodecene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyloxy-5E-dodecene
• 英文别名: [(E)-dodec-5-enoxy]methylbenzene
• 化学式: C₁₉H₃₀O
• 分子量: 274.447
• InChiKey: ZCCVKWQXVAQKMD-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-辛炔 、 4-溴丁醚苄酯 在 Schwartz's reagent 、 bis(acetylacetonato)palladium(II) 、 lithium bromide 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 为溶剂， 反应 25.0h， 以84%的产率得到1-benzyloxy-5E-dodecene
  参考文献：
  名称：

  Cross-Couplings of Alkyl Electrophiles under “Ligandless” Conditions:  Negishi Reactions of Organozirconium Reagents

  摘要：

  This report establishes that simple, "ligandless" palladium complexes can catalyze the first zirconium-Negishi reactions of alkyl electrophiles. In view of the attractiveness of ligandless catalysts (cost, simplicity, and ease of purification), these observations add a significant and intriguing new dimension to the development of effective palladium-based processes for coupling alkyl electrophiles.

  DOI：

  10.1021/ja0393729

文献信息

• Cross-Couplings of Alkyl Electrophiles under “Ligandless” Conditions:  Negishi Reactions of Organozirconium Reagents
  作者：Sheryl L. Wiskur、Alexander Korte、Gregory C. Fu

  DOI：10.1021/ja0393729

  日期：2004.1.1

  This report establishes that simple, "ligandless" palladium complexes can catalyze the first zirconium-Negishi reactions of alkyl electrophiles. In view of the attractiveness of ligandless catalysts (cost, simplicity, and ease of purification), these observations add a significant and intriguing new dimension to the development of effective palladium-based processes for coupling alkyl electrophiles.