maleic acid dichloroanhydride | 22542-53-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: maleic acid dichloroanhydride
• 英文别名: maleic acid chloroanhydride；maleoyl dichloride；maleoyl chloride；Maleoylchlorid；maleic acid dichloride；fumaryl dichloride；2-trans-Butendioic acid chloride；(Z)-but-2-enedioyl dichloride
• CAS: 22542-53-6
• 化学式: C₄H₂Cl₂O₂
• 分子量: 152.965
• InChiKey: ZLYYJUJDFKGVKB-UPHRSURJSA-N

物化性质

• 熔点：
  108-110 °C(Solv: benzene (71-43-2))
• 沸点：
  162.5±0.0 °C(Predicted)
• 密度：
  2.4384 g/cm3(Temp: 33.50 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  maleic acid dichloroanhydride 在 三乙胺 作用下， 生成 [(3Z,6aS,7R,9R)-7-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]-2,5-dioxo-6a,7,9,9a-tetrahydrofuro[3,4-b][1,4]dioxocin-9-yl]methyl 2-methylpropanoate
  参考文献：
  名称：

  US11541071

  摘要：

  公开号：
• 作为产物：
  描述：

  反丁烯二酰氯 以 various solvent(s) 为溶剂， 生成 maleic acid dichloroanhydride
  参考文献：
  名称：

  UV-laser photoisomerization of fumaryl chloride

  摘要：

  Fourier transform infrared spectra of fumaryl chloride 1 isolated in an argon matrix at 10 K have been analyzed. The comparison between the ab initio HF/6-31G calculated infrared spectra with the experimental ones reveals the existence of three planar conformers, the cis-cis la, the cis-trans Ib and the trans-trans Ic, Laser UV irradiation of 1 at lambda = 340 nm yields maleoyl chloride 2 by a carbon carbon double bond photoisomerization process. The first identification of this compound was performed by comparison of the experimental infrared spectra with the calculated ones at the MP2/6-1G** level. AMI semiempirical and ab initio calculations were used to calculate the structure and the relative stability of the three non planar maleoyl chloride conformers. (C) 2000 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s1386-1425(99)00129-8

文献信息

• Receptor
  申请人：Nelissen Hubertus Franciscus Martinus

  公开号：US20080221218A1

  公开（公告）日：2008-09-11

  The present invention relates to synthetic receptors, products and methods which are useful in relation to the binding of phosphates for example in water purification and renal dialysis systems.

  本发明涉及合成受体、产品和方法，这些受体、产品和方法在与磷酸盐的结合有关的应用中非常有用，例如在水净化和肾透析系统中。
• Synthetically accessible, high-affinity phosphate anion receptors
  作者：Hubertus (Bart) F. M. Nelissen、David K. Smith

  DOI：10.1039/b706227c

  日期：——

  We report synthetically accessible receptors with protonated amines attached to a conformationally constrained backbone including amide units, and demonstrate that these receptors have high affinities (log K > 5) for phosphate anions in aqueous media at pH 7 in the presence of high concentrations of competitive chloride anions (ca. 100-fold excess).

  我们合成了易于获取的受体分子，它们含有连接在包含酰胺单元的构象约束骨架上的质子化胺部分，并证明这些受体在pH 7的水溶液中，即使在存在高浓度竞争性氯离子（大约100倍过量）的情况下，对磷酸根阴离子仍具有高亲和力（log K > 5）。
• Synthesis and antiacetylcholinesterase activity of 2-alkyl(phenyl)-N-(ω-hydro-xyalkyl)pyrrolidine esters
  作者：N. A. Morozova、V. A. Sedavkina

  DOI：10.1007/bf02218924

  日期：1996.1

  acetylcholinesterase among the pyrrolidine alcohols and their derivatives, because these compounds include strongly basic tertiary nitrogen atoms and various functional groups favoring immobilization of the molecules on the active surface of acetylcholinesterase. In this paper we report on the results of studying the anticholinesterase activity of esters of pyrrolylalkanols (I) and monoand dicarboxylic, aliphatic

  在之前的论文 [I] 中，我们介绍了吡咯烷醇的氨基甲酸酯对乙酰胆碱酯酶的抑制活性的研究结果。在某些情况下，新化合物的抗胆碱酯酶活性接近众所周知的天然抑制剂加兰他敏 (pls0 5.3) [2]。发现继续在吡咯烷醇及其衍生物中寻找乙酰胆碱酯酶抑制剂是有利的，因为这些化合物包括强碱性叔氮原子和各种有利于将分子固定在乙酰胆碱酯酶活性表面上的官能团。在本文中，我们报告了研究吡咯烷醇 (I) 和单和二羧酸、脂肪族、芳香族和杂环酸 (II, III) 的酯的抗胆碱酯酶活性的结果。
• TWO ATOM BRIDGED DICARBONATE COMPOUNDS AS INTERNAL DONORS IN CATALYSTS FOR POLYPROPYLENE MANUFACTURE
  申请人：Coalter, III Joseph N.

  公开号：US20130245306A1

  公开（公告）日：2013-09-19

  A compound suitable for use as an internal electron donor having a structure: wherein R 1 is independently at each occurrence, an aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; R 2 is independently at each occurrence, a hydrogen atom or aliphatic or aromatic hydrocarbon, or substituted hydrocarbon group containing from 1 to 20 carbon atoms; and R3 is an aliphatic hydrocarbyl group having 1 to 3 carbon atoms.

  一种适合用作内电子给体的化合物，其结构为：其中R1在每次出现时独立地为含有1至20个碳原子的脂肪族或芳香族烃或取代烃基团；R2在每次出现时独立地为氢原子或含有1至20个碳原子的脂肪族或芳香族烃或取代烃基团；而R3为含有1至3个碳原子的脂肪族烃基团。
• Protein crosslinkers, crosslinking methods and applications thereof
  申请人：Pathak Chandrashekhar P.

  公开号：US20070248567A1

  公开（公告）日：2007-10-25

  Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological fluid are blood, plasma, or serum.

  这项披露涉及一种交联生物液体的方法，包括将生物液体与交联剂结合，以共价交联生物液体内源蛋白质形成交联凝胶。生物液体的例子包括血液、血浆或血清。