5-(2-chloro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid hydroxyamide | 823220-09-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-(2-chloro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid hydroxyamide
• 英文别名: 3-Isoxazolecarboxamide, 5-[[(2-chlorophenyl)thio]methyl]-N-hydroxy-；5-[(2-chlorophenyl)sulfanylmethyl]-N-hydroxy-1,2-oxazole-3-carboxamide
• CAS: 823220-09-3
• 化学式: C₁₁H₉ClN₂O₃S
• 分子量: 284.723
• InChiKey: VCZVWKIHPCHVNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  邻氯苯硫酚 在 氢氧化钾 、 盐酸羟胺 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 5-(2-chloro-phenylsulfanylmethyl)-isoxazole-3-carboxylic acid hydroxyamide
  参考文献：
  名称：

  Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents

  摘要：

  A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.087

文献信息

• [EN] ISOXAZOLES AS PEPTIDE DEFORMYLASE INHIBITORS<br/>[FR] ISOXAZOLES UTILISES COMME INHIBITEURS DE PEPTIDE DEFORMALYSE
  申请人：ARPIDA AS

  公开号：WO2005026133A1

  公开（公告）日：2005-03-24

  Isoxazole compounds of formula (I) and pharmaceutically acceptable salts or esters thereof are peptide deformylase inhibitors useful in the treatment or prevention of infections and other disease in which peptide deformylases are involved, especially in the treatment of bacterial and parasitic infections, for example infections fully or partly caused by microorganisms belonging to Staphylococcus, Enterococcus, Streptococcus, Haemophilus, Moraxella, Escherichia, Mycobacterium, Mycoplasma, Pseudomonas, Chlamydia, Rickettsia, Klebsiella, Shigella, Salmonella, Bordetella, Clostridium, Helicobacter, Campylobacter, Legionella or Neisseria.

  式(I)的异噁唑化合物及其药学上可接受的盐或酯是肽变形酶抑制剂，在治疗或预防涉及肽变形酶的感染和其他疾病方面非常有用，特别是在治疗细菌和寄生虫感染方面，例如完全或部分由属于葡萄球菌、肠球菌、链球菌、流感嗜血杆菌、嗜莫雷拉菌、大肠杆菌、分枝杆菌、支原体、假单胞菌、沙眼衣原体、立克次体、克雷伯菌、志贺氏菌、沙门氏菌、百日咳杆菌、梭菌、幽门螺杆菌、空肠弯曲菌、军团菌或莫拉氏菌等微生物引起的感染的治疗中。
• ISOXAZOLES AS PEPTIDE DEFORMYLASE INHIBITORS
  申请人：Arpida A/S

  公开号：EP1664000A1

  公开（公告）日：2006-06-07
• Isoxazoles as peptide deformylase inhibitors
  申请人：Cali Patrizia

  公开号：US20070043062A1

  公开（公告）日：2007-02-22

  Isoxazole compounds of formula (I) and pharmaceutically acceptable salts or esters thereof are peptide deformylase inhibitors useful in the treatment or prevention of infections and other disease in which peptide deformylases are involved, especially in the treatment of bacterial and parasitic infections, for example infections fully or partly caused by microorganisms belonging to Staphylococcus, Enterococcus, Streptococcus, Haemophilus, Moraxella, Escherichia, Mycobacterium, Mycoplasma, Pseudomonas, Chlamydia, Rickettsia, Klebsiella, Shigella, Salmonella, Bordetella, Clostridium, Helicobacter, Campylobacter, Legionella or Neisseria .
• Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents
  作者：Patrizia Calí、Lars Nærum、Seema Mukhija、Anders Hjelmencrantz

  DOI：10.1016/j.bmcl.2004.09.087

  日期：2004.12

  A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported. (C) 2004 Elsevier Ltd. All rights reserved.