2-[6-(o-anilinyl)-3-hexen-1,5-diynyl]benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[6-(o-anilinyl)-3-hexen-1,5-diynyl]benzonitrile
• 英文别名: 2-[(Z)-6-(2-aminophenyl)hex-3-en-1,5-diynyl]benzonitrile
• 化学式: C₁₉H₁₂N₂
• 分子量: 268.318
• InChiKey: FXQSMCFKUSIEOT-UPHRSURJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-乙炔基苯甲腈 在 四(三苯基膦)钯 copper(l) iodide 、 四丁基氟化铵 、 正丁胺 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 12.0h， 生成 2-[6-(o-anilinyl)-3-hexen-1,5-diynyl]benzonitrile
  参考文献：
  名称：

  Remarkable G2/M phase arrest and apoptotic effect performed by 2-(6-aryl-3-hexen-1,5-diynyl) benzonitrile antitumor agents

  摘要：

  2-(6-aryl-3-hexen-1,5-diynyl)benzonitriles 3a-j showed growth inhibition effects on a full panel of 60 human cancer cell lines in low micro-concentrations, in which compounds 3c,d displayed a significant G2/M arrest in the cell growth cycle compared with other derivatives and an apoptotic progress induction were also shown by 3a-d. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.12.014

文献信息

• Remarkable G2/M phase arrest and apoptotic effect performed by 2-(6-aryl-3-hexen-1,5-diynyl) benzonitrile antitumor agents
  作者：Yu-Hsiang Lo、Chi-Fong Lin、Ming-Chu Hsieh、Ming-Jung Wu

  DOI：10.1016/j.bmc.2003.12.014

  日期：2004.3

  2-(6-aryl-3-hexen-1,5-diynyl)benzonitriles 3a-j showed growth inhibition effects on a full panel of 60 human cancer cell lines in low micro-concentrations, in which compounds 3c,d displayed a significant G2/M arrest in the cell growth cycle compared with other derivatives and an apoptotic progress induction were also shown by 3a-d. (C) 2004 Elsevier Ltd. All rights reserved.