4-acetamido-3-nitrobenzophenone | 53502-23-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-acetamido-3-nitrobenzophenone
• 英文别名: acetic acid-(4-benzoyl-2-nitro-anilide)；Essigsaeure-(4-benzoyl-2-nitro-anilid)；3-Nitro-4-acetamino-benzophenon；2-nitro-4-benzoyl-acetanilide；4-Acetamido-3-nitrobenzophenon；2-Nitro-4-benzoyl-acetanilid；N-(4-benzoyl-2-nitrophenyl)acetamide
• CAS: 53502-23-1
• 化学式: C₁₅H₁₂N₂O₄
• 分子量: 284.271
• InChiKey: BFNPQKPWCMCEOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  92
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-acetamido-3-nitrobenzophenone 在 硫酸 作用下， 生成 4-氨基-3-硝基二苯甲酮
  参考文献：
  名称：

  Antiviral thiazolinyl benzimidazoles

  摘要：

  某些噻唑基或噻嗪基酮苯并咪唑化合物及其衍生物可用作抗病毒药物。

  公开号：

  US04150028A1
• 作为产物：
  描述：

  4-苯甲酰基乙酰苯胺 在 硝酸 作用下， 以95%的产率得到4-acetamido-3-nitrobenzophenone
  参考文献：
  名称：

  Ayyangar, N. R.; Lahoti, R. J.; Daniel, Thomas, Organic Preparations and Procedures International, 1991, vol. 23, # 5, p. 627 - 632

  摘要：

  DOI：

文献信息

• Carbonyl-substituted 1-sulfonylbenzimidazoles
  申请人：Eli Lilly and Company

  公开号：US04118742A1

  公开（公告）日：1978-10-03

  Certain carbonyl-substituted-1-sulfonylbenzimidazole compounds are useful as antiviral agents.

  某些羰基取代的1-磺酰基苯并咪唑化合物可用作抗病毒药物。
• Antiviral thiazolinyl benzimidazoles
  申请人：Eli Lilly and Company

  公开号：US04150028A1

  公开（公告）日：1979-04-17

  Certain thiazolinyl or thiazinyl ketobenzimidazole compounds and derivatives thereof are useful as antiviral agents.

  某些噻唑基或噻嗪基酮苯并咪唑化合物及其衍生物可用作抗病毒药物。
• Benzoylphenylisothioureas
  申请人：Bayer Aktiengesellschaft

  公开号：US03968314A1

  公开（公告）日：1976-07-06

  Benzoylphenylisothioureas of the formula: ##SPC1## Wherein R is alkyl of 1 to 12 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, alkenyl of 2 to 12 carbon atoms or aralkyl unsubstituted or substituted in the aryl moiety by one or more substituents selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms and halogen; R.sup.1 is alkyl of 1 to 4 carbon atoms, cyclohexyl or phenyl; and R.sup.2 is hydrogen; alkyl of 1 to 18 carbon atoms unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, cyano, alkoxy of 1 to 4 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms, phenoxy, halophenoxy, alkylphenoxy and alkoxyphenoxy; cycloalkyl of 5 to 8 carbon atoms; aralkyl unsubstituted or substituted in the aryl moiety by one or more substituents selected from the group consisting of halogen, alkyl of 1 to 4 carbon atoms and alkoxy of 1 to 4 carbon atoms; aryl unsubstituted or substituted by one or more substitutents selected from the group consisting of halogen, alkyl of 1 to 4 carbon atoms and alkoxy of 1 to 4 carbon atoms; 1-furyl; or a moiety of the formula: -NR"R"' wherein R" is hydrogen or alkyl of 1 to 4 carbon atoms, and R"' is hydrogen; alkyl of 1 to 18 carbon atoms unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, cyano, alkoxy of 1 to 4 carbon atoms and alkoxycarbonyl of 2 to 5 carbon atoms; cycloalkyl of 5 to 8 carbon atoms; aralkyl unsubstituted or substituted in the aryl moiety by one or more substituents selected from the group consisting of halogen, lower alkyl and lower alkoxy; phenyl unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, lower alkyl and lower alkoxy; acyl of up to 18 carbon atoms unsubstituted or substituted by one or more substituents selected from the group consisting of halogen and lower alkoxy; aroyl unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, lower alkyl and lower alkoxy; alkylsulphonyl of 1 to 18 carbon atoms unsubstituted or substituted by one or more substituents selected from the group consisting of halogen, amino, lower alkyl and lower alkoxy; or dialkylamino of 1 to 4 carbon atoms in each alkyl moiety; or R" and R"' together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclic ring wherein the nitrogen atom is the only heteroatom or wherein oxygen or sulfur is also present as a ring member, Are produced by reacting a thiourea of the formula: ##SPC2## Wherein R.sup.1 and R.sup.2 are as above defined, With an alkylating agent of the formula: R -- Y wherein R is as above defined; and Y is halogen, arylsulphonate or alkylsulphonate, In the presence of a base and a diluent. The benzoylphenylisothioureas described above are useful for their anthelmintic activity.

  该文描述了一种公式为：## SPC1 ##的苯甲酰基异硫脲化合物，其中R为1至12个碳原子的烷基，3至8个碳原子的环烷基，2至12个碳原子的烯基或芳基烷基，未经取代或在芳基中取代一个或多个取代基，所述取代基选自1至4个碳原子的烷基，1至4个碳原子的烷氧基和卤素; R1为1至4个碳原子的烷基，环己基或苯基; R2为氢; 1至18个碳原子的烷基，未经取代或在所述烷基上取代一个或多个取代基，所述取代基选自卤素，氰基，1至4个碳原子的烷氧基，2至5个碳原子的烷氧羰基，苯氧基，卤代苯氧基，烷基苯氧基和烷氧基苯氧基; 5至8个碳原子的环烷基; 未经取代或在芳基中取代一个或多个取代基的芳基烷基，所述取代基选自卤素，1至4个碳原子的烷基和1至4个碳原子的烷氧基; 未经取代或在芳基中取代一个或多个取代基的芳基，所述取代基选自卤素，1至4个碳原子的烷基和1至4个碳原子的烷氧基; 1-呋喃基; 或公式为：-NR“R”'的一种基团，其中R“为氢或1至4个碳原子的烷基，R”'为氢; 1至18个碳原子的烷基，未经取代或在所述烷基上取代一个或多个取代基，所述取代基选自卤素，氰基，1至4个碳原子的烷氧基和2至5个碳原子的烷氧羰基; 5至8个碳原子的环烷基; 未经取代或在芳基中取代一个或多个取代基的芳基烷基，所述取代基选自卤素，较低的烷基和较低的烷氧基; 未经取代或在芳基中取代一个或多个取代基的苯基，所述取代基选自卤素，较低的烷基和较低的烷氧基; 酰基，其碳原子数最多为18个，未经取代或在所述酰基上取代一个或多个取代基，所述取代基选自卤素和较低的烷氧基; 未经取代或在所述芳基上取代一个或多个取代基的芳基酰基，所述取代基选自卤素，较低的烷基和较低的烷氧基; 1至18个碳原子的烷基磺酰基，未经取代或在所述烷基上取代一个或多个取代基，所述取代基选自卤素，氨基，较低的烷基和较低的烷氧基; 或1至4个碳原子的二烷基氨基，每个烷基中都未经取代; 或R“和R”'与它们连接的氮原子一起形成4至7个成员的杂环环，其中氮原子是唯一的杂原子或其中也存在氧或硫作为环成员。该化合物通过将公式为：## SPC2 ##的硫脲与公式为：R-Y的烷基化剂反应而制得，其中R和Y的定义如上所述，并在碱和稀释剂的存在下进行。上述苯甲酰基异硫脲化合物对于其驱虫活性是有用的。
• Alkylidenylmethyl-substituted 1-sulfonylbenzimidazoles
  申请人：Eli Lilly and Company

  公开号：US04174454A1

  公开（公告）日：1979-11-13

  Certain alkylidenylmethyl-substituted-1-sulfonylbenzimidazole compounds are useful as antiviral agents.

  某些烷基亚甲基取代的1-磺酰基苯并咪唑化合物可用作抗病毒剂。
• Antiviral thiazinyl benzimidazoles
  申请人：Eli Lilly and Company

  公开号：US04216313A1

  公开（公告）日：1980-08-05

  Certain thiazolinyl or thiazinyl ketobenzimidazole compounds and derivatives thereof are useful as antiviral agents.

  某些噻唑基或噻吩基酮基苯并咪唑化合物及其衍生物可用作抗病毒剂。