| 1310799-63-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• CAS: 1310799-63-3
• 化学式: C₂₇H₃₃N₃O₇
• 分子量: 511.575
• InChiKey: BXEOMEWRHCCSHG-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  37.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  125.48
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 sodium carbonate 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 7.67h， 生成 N-α-Fmoc-(4-morpholine-1,8-naphthalimido)-Lysine
  参考文献：
  名称：

  Peptide Functionalized Polydiacetylene Liposomes Act as a Fluorescent Turn-On Sensor for Bacterial Lipopolysaccharide

  摘要：

  Mixed polydiacetylene (PDA) liposomes functionalized on their surface with a fluorescent pentalysine peptide derivative and histidine in a ratio of 1:9 can identify bacterial lipopolysaccharide (LPS). Upon photopolymerization of the self-assembled liposomes the initial fluorescence of the peptide-diacetylene amphiphiles is quenched. Interaction with LPS in aqueous solution or on the surface of E. coli DHSa restores the fluorescence. This increase in fluorescence is selective for LPS relative to other negatively charged analytes including nucleotides and ctDNA This simple turn-on fluorescent sensor allows detecting LPS even at low micromolar concentrations.

  DOI：

  10.1021/ja204013u
• 作为产物：
  描述：

  4-溴-1,8-萘二甲酸酐 在 碳酸氢钠 作用下， 以 1,4-二氧六环 、 甲乙醚 、 水 为溶剂， 反应 26.17h， 生成
  参考文献：
  名称：

  Peptide Functionalized Polydiacetylene Liposomes Act as a Fluorescent Turn-On Sensor for Bacterial Lipopolysaccharide

  摘要：

  Mixed polydiacetylene (PDA) liposomes functionalized on their surface with a fluorescent pentalysine peptide derivative and histidine in a ratio of 1:9 can identify bacterial lipopolysaccharide (LPS). Upon photopolymerization of the self-assembled liposomes the initial fluorescence of the peptide-diacetylene amphiphiles is quenched. Interaction with LPS in aqueous solution or on the surface of E. coli DHSa restores the fluorescence. This increase in fluorescence is selective for LPS relative to other negatively charged analytes including nucleotides and ctDNA This simple turn-on fluorescent sensor allows detecting LPS even at low micromolar concentrations.

  DOI：

  10.1021/ja204013u