o-tolyl-aminooxalyl chloride | 153072-40-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: o-tolyl-aminooxalyl chloride
• 英文别名: o-Tolyl-oxalamoylchlorid；Oxalsaeure-chlorid-o-toluidid；o-Tolyl-oxamidsaeure-chlorid；1-Chloro-2-[(2-methylphenyl)amino]ethandione；2-(2-methylanilino)-2-oxoacetyl chloride
• CAS: 153072-40-3
• 化学式: C₉H₈ClNO₂
• 分子量: 197.621
• InChiKey: VYNUSJXBGSQJAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  o-tolyl-aminooxalyl chloride 在 aluminum (III) chloride 作用下， 以 二氯甲烷 为溶剂， 以135.2 g的产率得到7-甲基靛红
  参考文献：
  名称：

  CN116836103

  摘要：

  公开号：
• 作为产物：
  描述：

  [(2-甲基苯基)氨基](氧代)乙酸 在 草酰氯 作用下， 以 二氯甲烷 为溶剂， 生成 o-tolyl-aminooxalyl chloride
  参考文献：
  名称：

  The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives

  摘要：

  The synthesis and biological evaluation of a series of novel isobenzofuran-based compounds are described. The compounds were evaluated for their immunosuppressive effects of T-cell proliferation and IMPDH type II inhibitor activity in vitro, as well as their structure-activity relationships were assessed. Several compounds demonstrated highly efficacious immunosuppressive properties, especially compounds 2d, 2e, 2h and 2j, which were superior to MPA, while compounds 2k, 2m, 2n, 4c and 5d exhibited an equipotent inhibitory activity compared to MPA. Generally, it was obviously demonstrated that alpha,beta-unsaturated amides proved more potent than the diamide and urea series. The present study provides a guide for further research on development of safe and effective immunosuppressive agents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.11.078

文献信息

• Biphenyl-substituted quinoline derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US06117885A1

  公开（公告）日：2000-09-12

  Compounds of the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, A, B, D and E are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

  式为##STR1##的化合物，其中X，R.sub.1，R.sub.2，R.sub.3，R.sub.4，R.sub.5，R.sub.6，A，B，D和E的定义如本文所述。这些化合物抑制肾素-血管紧张素系统的作用，因此例如作为降压药物是有用的。
• Benzylamine derivative
  申请人：Nagasawa Masaaki

  公开号：US20060194841A1

  公开（公告）日：2006-08-31

  The invention provides a compound which exhibits satisfactory peroral absorbability and excellent antagonistic activity against NK-1 receptor or NK-2 receptor. The compound is a benzylamine derivative represented by formula (1) or a salt thereof.

  本发明提供了一种化合物，该化合物表现出令人满意的口服吸收性以及对NK-1受体或NK-2受体的优异拮抗活性。该化合物是由式（1）表示的苄基胺衍生物或其盐。
• Biphenyl-substituted quinoline and naphthyridines derivatives as angiotensine II antagonists
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0556060A1

  公开（公告）日：1993-08-18

  Compounds of the formula wherein X, R₁, R₂, R₃, R₄, R₅, R₆, A, B, D and E are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

  式中的化合物 其中 X、R₁、R₂、R₃、R₄、R₅、R₆、A、B、D 和 E 如本文所定义。这些化合物可抑制血管紧张素 II 的作用，因此可用作降压药等。
• BENZYLAMINE DERIVATIVE
  申请人：ZERIA PHARMACEUTICAL CO., LTD.

  公开号：EP1650189A1

  公开（公告）日：2006-04-26

  The invention provides a compound which exhibits satisfactory peroral absorbability and excellent antagonistic activity against NK-1 receptor or NK-2 receptor. The compound is a benzylamine derivative represented by formula (1) or a salt thereof.

  本发明提供了一种化合物，它具有令人满意的口腔吸收性和对 NK-1 受体或 NK-2 受体的优异拮抗活性。该化合物是一种由式（1）表示的苄胺衍生物或其盐。
• US6117885A
  申请人：——

  公开号：US6117885A

  公开（公告）日：2000-09-12