2,3-吡啶二甲醛 | 4663-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,3-吡啶二甲醛
• 英文名称: pyridine-2,3-dicarbaldehyde
• 英文别名: 2,3-Diformyl-pyridin；Pyridin-2,3-dialdehyd
• CAS: 4663-93-8
• 化学式: C₇H₅NO₂
• 分子量: 135.122
• InChiKey: OYBLXLFKRJWZJG-UHFFFAOYSA-N

物化性质

• 沸点：
  277.4±25.0 °C(Predicted)
• 密度：
  1.274±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3-吡啶二甲醛 在 一水合肼 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以534 mg的产率得到吡啶并[2,3-d]哒嗪
  参考文献：
  名称：

  银催化 1,2-二嗪和硅氧基炔烃的形式逆电子需狄尔斯-阿尔德反应

  摘要：

  已经开发出一种高效的银催化 1,2-二嗪和甲硅烷氧基炔的形式逆电子需求狄尔斯-阿尔德反应。这些反应可以方便地获得各种甲硅烷氧基萘和蒽，这些化合物可以在温和的反应条件下使用低催化剂负载量以良好到高的产率形成。

  DOI：

  10.1021/ja302537j
• 作为产物：
  描述：

  2,3-吡啶二甲酸二甲酯 在 selenium(IV) oxide 、 sodium tetrahydroborate 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 生成 2,3-吡啶二甲醛
  参考文献：
  名称：

  Coplanar Tetracyclic π‐Excess σ ² P Ligands

  摘要：

  AbstractThe acid‐catalyzed reactions of 5‐methyl‐2‐phosphanylaniline (1) with dialdehydes were studied. Whereas the reaction with glyoxal provides a mixture of two 1H‐1,3‐benzazaphospholes, 2 and 3, by concomitant reduction of a CHO group and C–C bond cleavage, respectively, the reaction with o‐phthalic dicarbaldehyde provided in excellent yield the tetracyclic planar benzazaphosphole 4, which was characterized by crystal structure analysis. The active hydrogen atoms, delivered by aromatization of a dihydrobenzazaphosphole intermediate, forms an N–CH2 bridge by reductive N‐alkylation. Pyridine‐2,6‐dicarbaldehyde reacts analogously but not chemoselectively and, thus, gives two isomers 5 and 6. Condensation with pyridine‐2,6‐dicarbaldehyde afforded the bis(benzazaphosphole)pyridine pincer ligand 7, but along with 2‐(benzazaphospholyl)‐6‐tolylpyridine (8) by partial P–C bond cleavage. The high upfield 31P NMR chemical shift of 4 compared to those of normal benzazaphospholes indicates it to be a particularly π‐rich σ2P ligand.

  DOI：

  10.1002/ejic.201300342

文献信息

• Method and compositions for identifying anti-HIV therapeutic compounds
  申请人：Arimilli N. Murty

  公开号：US20050239054A1

  公开（公告）日：2005-10-27

  Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

  提供了一种识别含有羧酸酯或磷酸酯基团取代的抗HIV治疗化合物的方法。可以选择使用新型酶GS-7340酯水解酶对这类化合物库进行筛选。还提供了与GS-7340酯水解酶相关的组合物和方法。
• [EN] COMPOSITION FOR TIN-SILVER ALLOY ELECTROPLATING COMPRISING A COMPLEXING AGENT<br/>[FR] COMPOSITION POUR L'ÉLECTROGALVANISATION D'ALLIAGE D'ÉTAIN ET D'ARGENT COMPRENANT UN AGENT COMPLEXANT
  申请人：BASF SE

  公开号：WO2019185468A1

  公开（公告）日：2019-10-03

  An aqueous composition comprising (a) metal ions comprising tin ions and silver ions and (b) at least one complexing agent of formula (C1) R1-X1-S-X21[D1-X22-]nS-X3-R2, (C2) R1-X1-S-X31-D2-[X32-S-]nX3-R2, (C3) R3-X1-S-X41-[D3-X42-]nS-X3-R4 wherein X1, X3 are independently selected from a linear or branched C1-C12 alkanediyl, which may be unsubstituted or substituted by OH; X21, X22 are independently selected from X1, which may be further substituted by -X5-COOR12, -X5-SO2-O-R12, a C2 to C6 polyoxyalkylene group of formula -(O-CH2- CHR11)z-OH, or a combination thereof, and -X1-NH-CO-X6-CO-NH-X1-; X31, X32 are independently selected from a chemical bond and X1; X41, X42 are independently selected from X1; X5 is a linear or branched Ci to C10 alkyl; X6 is selected from X1 and a divalent 5 or 6 membered aromatic group; R1, R2 are independently selected from a monovalent 5 or 6 membered aromatic N- heterocyclic group comprising one N atom or two N atoms which are separated by at least one C atom, and its derivatives received by N-alkylation with a C1-C6- alkyl group, which may be substituted by --COOR12 or -SO2-O-R12, and which aromatic N- heterocyclic group may optionally further comprise, under the proviso that X21 is substituted by at least one OH, one S atom; R3, R4 are independently selected from a monovalent 5 or 6 membered aliphatic N- heterocyclic group comprising one N atom and one O atom; D1 is independently selected from S, O and NR10-; D2 is (a) a divalent 5 or 6 membered aliphatic heterocyclic ring system comprising 1 or 2 S atoms, or (b) a 5 or 6 membered aromatic heterocyclic ring system comprising at least two N atoms and optionally one or two S atoms; D3 is independently selected from S and NR10-; n is an integer of from 0 to 5; z is an integer from 1 to 50; R10 is selected from H and a linear or branched C1-C12 alkyl; R11 is selected from H and a linear or branched C1 to C6 alkyl; and R12 is selected from R10 and a cation.

  一种水性组合物，包括（a）包括锡离子和银离子的金属离子和（b）至少一种具有以下结构的络合剂：（C1）R1-X1-S-X21[D1-X22-]nS-X3-R2，（C2）R1-X1-S-X31-D2-[X32-S-]nX3-R2，（C3）R3-X1-S-X41-[D3-X42-]nS-X3-R4，其中X1、X3可独立地选择自线性或支链的C1-C12脂肪二亚基，可以未取代或被OH取代；X21、X22可独立地选择自X1，可以进一步被-X5-COOR12，-X5-SO2-O-R12，具有式-(O-CH2-CHR11)z-OH的C2到C6聚氧烷基，或其组合物取代，以及-X1-NH-CO-X6-CO-NH-X1-；X31、X32可独立地选择自化学键和X1；X41、X42可独立地选择自X1；X5是线性或支链的Ci到C10烷基；X6选择自X1和双价的5或6元芳香族基；R1、R2可独立地选择自包括一个N原子或两个N原子的单价5或6元芳香N-杂环基，通过N-烷基化与C1-C6烷基基团取代的衍生物，可以被--COOR12或-SO2-O-R12取代，该芳香N-杂环基可以选择性地进一步包括，在X21至少被一个OH取代的条件下，一个S原子；R3、R4可独立地选择自包括一个N原子和一个O原子的单价5或6元脂肪N-杂环基；D1可独立地选择自S、O和NR10-；D2是（a）包括1或2个S原子的双价5或6元脂肪杂环环系统，或（b）包括至少两个N原子和可选地一个或两个S原子的5或6元芳香杂环环系统；D3可独立地选择自S和NR10-；n是从0到5的整数；z是从1到50的整数；R10选择自H和线性或支链的C1-C12烷基；R11选择自H和线性或支链的C1到C6烷基；R12选择自R10和阳离子。
• Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones
  作者：Steven D. Paget、Barbara D. Foleno、Christine M. Boggs、Raul M. Goldschmidt、Dennis J. Hlasta、Michele A. Weidner-Wells、Harvey M. Werblood、Ellyn Wira、Karen Bush、Mark J. Macielag

  DOI：10.1016/j.bmcl.2003.08.031

  日期：2003.12

  A novel series of oxazolidinones containing a pyrroloaryl substituent was synthesized and screened against a representative panel of susceptible and resistant Gram-positive bacteria. Several members of this series were found to have antibacterial activity comparable to or better than linezolid.

  合成了一系列新的含吡咯并芳基取代基的恶唑烷酮，并针对代表性的易感和耐药革兰氏阳性细菌进行了筛选。发现该系列的几个成员具有与利奈唑胺相当或更好的抗菌活性。
• Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
  申请人：——

  公开号：US20020161029A1

  公开（公告）日：2002-10-31

  Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: 1 wherein Y is a radical of Formulae II or III: 2 in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

  具有以下结构的双环杂环取代苯基噁唑啉酮化合物：其中Y是Formulae II或III的基团：其中取代基具有描述中指示的含义。这些化合物可用作抗菌剂。
• Aza-isoindolo and isoindolo-azaquinoxaline derivatives with antiproliferative activity
  作者：Barbara Parrino、Anna Carbone、Virginia Spanò、Alessandra Montalbano、Daniele Giallombardo、Paola Barraja、Alessandro Attanzio、Luisa Tesoriere、Claudia Sissi、Manlio Palumbo、Girolamo Cirrincione、Patrizia Diana

  DOI：10.1016/j.ejmech.2015.03.009

  日期：2015.4

  Three new ring systems, pyrido[2′,3′:3,4]pyrrolo[1,2-a]quinoxalines, pyrido[3′,2′:3,4]pyrrolo[1,2-a]quinoxalines and pyrido[2′,3′:5,6]pyrazino[2,1-a]isoindoles, were synthesized through an aza-substitution on the already active isoindolo-quinoxaline system and in particular in the position 7 or 4 of the isoindole moiety and in position 5 of the quinoxaline portion. All new compounds were screened by

  三种新的环系统，吡啶并[2'，3'：3,4]吡咯并[1,2- a ]喹喔啉，吡啶并[3'，2'：3,4]吡咯并[1,2- a ]喹喔啉和吡啶[2'，3'：5,6]吡嗪并[2,1- a ]异吲哚是通过在已经具有活性的异吲哚并喹喔啉系统上，特别是在异吲哚部分的7或4位和在喹喔啉部分的位置5。所有新化合物均由美国国家癌症研究所（Bethesda，MD）针对60种人类肿瘤细胞系进行了筛选。pGI 50活性最高的衍生物的生物学结果值在7.09至7.27之间，证实了甲氧基取代基的存在对于生物活性的重要性。所选喹喔啉的抗增殖作用与细胞凋亡和细胞周期的G2 / M期停滞有关。还评估了化合物的DNA结合特性，以研究可能的作用机理。

表征谱图