试剂2-Nitro-5-(2-propynyloxy)benzyl4-cyano-4-(phenylcarbonothioylthio)pentanoate | 1318075-32-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 试剂2-Nitro-5-(2-propynyloxy)benzyl4-cyano-4-(phenylcarbonothioylthio)pentanoate
• 英文名称: 2-nitro-5-(2-propynyloxy)benzyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate
• 英文别名: 2-Nitro-5-(prop-2-yn-1-yloxy)benzyl 4-cyano-4-((phenylcarbonothioyl)thio)pentanoate；(2-nitro-5-prop-2-ynoxyphenyl)methyl 4-(benzenecarbonothioylsulfanyl)-4-cyanopentanoate
• CAS: 1318075-32-9
• 化学式: C₂₃H₂₀N₂O₅S₂
• 分子量: 468.554
• InChiKey: IOYDTDXAMFFKOA-UHFFFAOYSA-N

物化性质

• 熔点：
  90-94°C
• 沸点：
  652.8±65.0 °C(Predicted)
• 密度：
  1.330±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  163
• 氢给体数：
  0
• 氢受体数：
  8

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  2-nitro-5-propargyloxybenzyl alcohol 、 4-氰基-4-(硫代苯甲酰)戊酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以83%的产率得到试剂2-Nitro-5-(2-propynyloxy)benzyl4-cyano-4-(phenylcarbonothioylthio)pentanoate
  参考文献：
  名称：

  光可裂解嵌段共聚物的高度有序的纳米多孔薄膜

  摘要：

  聚（苯乙烯-嵌段-环氧乙烷）与ö硝基苄酯光可结（PS- ħ ν-PEO）通过组合RAFT聚合合成和“点击化学”的方法，并且表示利用用于合成这种方法的第一个报告光可裂解的嵌段共聚物。溶剂退火后，从PS-制备高度有序的薄膜ħ ν-PEO。经过非常温和的紫外线照射并连续用水冲洗后，PS- hν-PEO薄膜被转变为孔径为15–20 nm且长程有序（超过2μm×2μm）的高度有序的纳米多孔PS薄膜。然后，结合毛细作用力通过旋涂将孔填充PDMS。用氧等离子体处理以除去PS模板后，获得二氧化硅纳米点的高度有序的阵列。这代表了第一个模板应用实例，该实例来自具有光可裂解结的嵌段共聚物衍生的高度有序的纳米多孔薄膜。

  DOI：

  10.1021/ma201416b

文献信息

• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• Polymerizable sulfonamide compounds and polymers thereof
  申请人：Massachusetts Institute of Technology

  公开号：US11155674B2

  公开（公告）日：2021-10-26

  Methods, compositions, reagents, and systems that allow for the preparation and utilization of sulfonamide salt polymer electrolytes are disclosed herein. Methods and reagents to prepare sulfonamide salt monomers are also disclosed herein. The sulfonamide salt polymer electrolytes can be used as components in energy storage devices, conductive materials, electrochemical cells, gels, adhesives, and drug delivery vehicles.

  本文公开了允许制备和利用磺胺盐聚合物电解质的方法、组合物、试剂和系统。本文还公开了制备磺胺盐单体的方法和试剂。磺胺盐聚合物电解质可用作能量存储设备、导电材料、电化学电池、凝胶、粘合剂和药物输送载体中的组件。
• POROUS MATERIALS, METHOD FOR PRODUCING SAME AND USES THEREOF
  申请人：ETH Zurich

  公开号：EP3495040A1

  公开（公告）日：2019-06-12

  Method for preparing surface-functionalized macro porous micro-clusters is proposed comprising at least the following individual steps in given order: a) synthesis of dispersed cross-linked polymeric latex primary core particles starting from at least one monomer or oligomer in an emulsion polymerization under starved conditions; b) synthesis of a shell layer on the surface of the primary core particles to form core-shell particles starting under starved conditions from the same at least one monomer or oligomer as in step a) and in addition to that at least one additional azide monomer; c) swelling of the core-shell particles with a liquid comprising at least one of the monomers or oligomers as used in a) as well as a polymerization initiator but preferably no azide monomer in particular not the additional azide monomer from step b); d) formation of agglomerates of the particles by application of shear; e) polymerization of the agglomerates to form the macro porous micro-clusters; f) direct or indirect surface-functionalization of the agglomerates by way of Cu-(I)-catalyzed or strain promoted azide-alkyne cycloaddition with the azide introduced in step b).

  本发明提出了制备表面功能化大孔径微簇的方法，至少包括以下按给定顺序排列的各个步骤： a) 以至少一种单体或低聚物为原料，在饥饿条件下进行乳液聚合，合成分散交联聚合胶乳主芯颗粒； b) 在饥饿条件下，用与步骤 a) 相同的至少一种单体或低聚物，以及至少另外一种叠氮单体，在原核粒子表面合成壳层，形成核壳粒子； c) 用一种液体溶胀核壳颗粒，该液体包含 a) 步骤中使用的至少一种单体或低聚物以及聚合引发剂，但最好不含叠氮单体，尤其是不含步骤 b) 中的附加叠氮单体； d) 施加剪切力使颗粒形成团聚体； e) 使团聚体聚合，形成大孔微团块； f) 通过 Cu-(I)催化或应变促进的叠氮烷烃与步骤 b) 中引入的叠氮化物进行环加成，使团聚体直接或间接表面功能化。
• ACRYLIC COPOLYMER, PREPARATION METHOD THEREFOR, AND ACRYLIC COPOLYMER COMPOSITION COMPRISING SAME
  申请人：LG CHEM, LTD.

  公开号：EP3750928A1

  公开（公告）日：2020-12-16

  The present invention relates to an acrylic copolymer, and more particularly, to an acrylic copolymer including: a main monomer-derived repeating unit; and a chain transfer agent-derived part, wherein the main monomer-derived repeating unit includes a (meth)acrylic acid alkyl ester monomer-derived repeating unit, a (meth)acrylic acid alkoxy alkyl ester monomer-derived repeating unit, and a crosslinking monomer-derived repeating unit, the chain transfer agent-derived part is derived from a chain transfer agent having a carbonothioylthio group, and the chain transfer agent-derived part is included in an amount of 0.03 parts by weight to 0.08 parts by weight with respect to 100 parts by weight of the main monomer-derived repeating unit, a method of preparing the same, and an acrylic copolymer composition including the same.

  本发明涉及一种丙烯酸共聚物，更具体地说，涉及一种丙烯酸共聚物，包括其中主单体衍生的重复单元包括(甲基)丙烯酸烷基酯单体衍生的重复单元、(甲基)丙烯酸烷氧基烷基酯单体衍生的重复单元和交联单体衍生的重复单元，链转移剂衍生的部分由具有硫代碳酰基的链转移剂衍生，链转移剂衍生的部分以 0.以 100 份主单体衍生重复单元的重量计，链转移剂衍生部分的含量为 0.03 至 0.08 份（按重量计）；制备方法；以及包括上述内容的丙烯酸共聚物组合物。
• Impact resistant cyclic phosphazenes
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US10544285B2

  公开（公告）日：2020-01-28

  An impact-modified composition and a method of making an impact-modified composition are provided. In an embodiment, the method includes reacting a phosphazene material with an acrylamide material to form a functionalized phosphazene material; initiating a polymerization reaction on a reaction mixture comprising the functionalized phosphazene material and one or more monomers to form an impact-modified phosphazene material; and adding the an impact-modified phosphazene material to a polymeric material.

  本发明提供了一种抗冲击改性组合物和一种抗冲击改性组合物的制造方法。在一个实施方案中，该方法包括：使磷化烯材料与丙烯酰胺材料反应，形成官能化磷化烯材料；在包含官能化磷化烯材料和一种或多种单体的反应混合物上引发聚合反应，形成抗冲改性磷化烯材料；以及将抗冲改性磷化烯材料添加到聚合材料中。