2-chloro-3-(hydroxymethyl)-6-phenylpyridine | 275383-94-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-chloro-3-(hydroxymethyl)-6-phenylpyridine
• 英文别名: (2-chloro-6-phenyl-pyridin-3-yl)-methanol；(2-chloro-6-phenylpyridin-3-yl)methanol
• CAS: 275383-94-3
• 化学式: C₁₂H₁₀ClNO
• 分子量: 219.671
• InChiKey: KUXNFYBSDROMQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-3-(hydroxymethyl)-6-phenylpyridine 、 碘甲基硼酸频哪醇酯 在 sodium hydride 、 sodium difluorohydrogenate 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 以12%的产率得到(2-氯-6-苯基-吡啶-3-基)-甲氧基甲基三氟硼酸钠
  参考文献：
  名称：

  EP2062901

  摘要：

  公开号：
• 作为产物：
  描述：

  2-chloro-6-phenylnicotinic acid methyl ester 在 lithium aluminium tetrahydride 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以86%的产率得到2-chloro-3-(hydroxymethyl)-6-phenylpyridine
  参考文献：
  名称：

  EP2062901

  摘要：

  公开号：

文献信息

• Sulfonamide compounds and uses thereof as medicines
  申请人：Fujisawa Pharmaceutical Co. Ltd.

  公开号：US06573274B1

  公开（公告）日：2003-06-03

  The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

  本发明涉及一种具有以下结构式(I)的磺胺类化合物：其中每个符号如规范中定义，其盐以及含有该化合物的药物组合物。该化合物可以作为一种有效的药剂，用于预防和治疗基于降糖作用可治愈的疾病，以及基于cGMP-PDE抑制作用、平滑肌松弛作用、支气管扩张作用、血管扩张作用、平滑肌细胞抑制作用和抗过敏作用可治愈的疾病。
• FLUOROBORON COMPOUND HAVING AROMATIC RING OR SALT THEREOF, AND METHOD FOR PRODUCING COMPOUND HAVING CYCLIC ETHER-FUSED AROMATIC RING USING THE SAME
  申请人：Tanaka Keigo

  公开号：US20100056788A1

  公开（公告）日：2010-03-04

  Provided is a fluoroboron compound which is highly safe and stable and is capable of forming a cyclic ether-fused ring by the intramolecular alkoxymethylation reaction, or a salt thereof. The compound can be synthesized by the intramolecular alkoxymethylation reaction of a fluoroboron compound represented by the formula (I) or a salt thereof in the presence of a metal catalyst. (wherein the moiety represented by the formula represents an aromatic ring; L represents a substituent such as a halogen atom; R represents a substituted or unsubstituted alkylene group having 1 or 2 carbon atoms; and M represents an alkali metal cation or the like, with the proviso that L and —R—OCH 2 BF 3 M are respectively located on contiguous carbon atoms on the aromatic ring, or in the case of a fused aromatic ring, on two carbon atoms adjacent to one carbon at the fused position).

  提供的是一种高度安全和稳定的氟硼化合物，能够通过分子内烷氧甲基化反应形成环状醚融合环，或其盐。该化合物可以在金属催化剂存在下，通过公式（I）表示的氟硼化合物或其盐的分子内烷氧甲基化反应合成。（其中由公式表示的基团代表芳香环；L代表取代基，如卤素原子；R代表取代或未取代的1或2个碳原子的烷基；M代表碱金属阳离子等，条件是L和-R-OCH2BF3M分别位于相邻的芳香环碳原子上，或在融合芳香环的情况下，在相邻的两个碳原子上，且其中一个碳原子在融合位置上）。
• Fluoroboron compound having aromatic ring or salt thereof, and method for producing compound having cyclic ether-fused aromatic ring using the same
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US08273885B2

  公开（公告）日：2012-09-25

  Provided is a fluoroboron compound which is highly safe and stable and is capable of forming a cyclic ether-fused ring by the intramolecular alkoxymethylation reaction, or a salt thereof. The compound can be synthesized by the intramolecular alkoxymethylation reaction of a fluoroboron compound represented by the formula (I) or a salt thereof in the presence of a metal catalyst. (wherein the moiety represented by the formula represents an aromatic ring; L represents a substituent such as a halogen atom; R represents a substituted or unsubstituted alkylene group having 1 or 2 carbon atoms; and M represents an alkali metal cation or the like, with the proviso that L and —R—OCH2BF3M are respectively located on contiguous carbon atoms on the aromatic ring, or in the case of a fused aromatic ring, on two carbon atoms adjacent to one carbon at the fused position).

  提供了一种高度安全稳定的氟硼化合物，能够通过分子内烷氧甲基化反应形成环状醚融合环，或其盐。该化合物可以在金属催化剂存在下，通过式(I)或其盐所代表的氟硼化合物的分子内烷氧甲基化反应合成。（其中，由式所代表的基团表示芳香环；L表示卤素原子等取代基；R表示具有1或2个碳原子的取代或未取代的烷基；M表示碱金属阳离子等，但须满足L和—R—OCH2BF3M分别位于芳香环上相邻的碳原子上，或者在融合芳香环的情况下，在相邻的两个碳原子上位于一个碳原子上）。
• SULFONAMIDE COMPOUNDS AND USES THEREOF AS MEDICINES
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1136492A1

  公开（公告）日：2001-09-26

  The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

  本发明涉及一种式 (I) 的磺酰胺化合物： 其中各符号如说明书中所定义的磺酰胺化合物、其盐和含有该化合物的药物组合物。该化合物可作为预防和治疗基于降血糖作用的疾病和基于 cGMP-PDE 抑制作用、平滑肌松弛作用、支气管扩张作用、血管扩张作用、平滑肌细胞抑制作用和过敏抑制作用的疾病的有效药物。
• FLUOROBORON COMPOUND HAVING AROMATIC RING OR SALT THEREOF, AND PROCESS FOR PRODUCTION OF COMPOUND HAVING CYCLIC ETHER-FUSED AROMATIC RING BY USING THE SAME
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2062901A1

  公开（公告）日：2009-05-27

  Provided is a fluoroboron compound which is highly safe and stable and is capable of forming a cyclic ether-fused ring by the intramolecular alkoxymethylation reaction, or a salt thereof. The compound can be synthesized by the intramolecular alkoxymethylation reaction of a fluoroboron compound represented by the formula (I) or a salt thereof in the presence of a metal catalyst. (wherein the moiety represented by the formula represents an aromatic ring; L represents a substituent such as a halogen atom; R represents a substituted or unsubstituted alkylene group having 1 or 2 carbon atoms; and M represents an alkali metal cation or the like, with the proviso that L and -R-OCH2BF3M are respectively located on contiguous carbon atoms on the aromatic ring, or in the case of a fused aromatic ring, on two carbon atoms adjacent to one carbon at the fused position).

  本发明提供了一种通过分子内烷氧甲基化反应能够形成环醚融合环的高度安全稳定的氟硼化合物或其盐。该化合物可在金属催化剂存在下，通过式（I）代表的氟硼化合物或其盐的分子内烷氧甲基化反应合成。 (其中由式 代表芳香环；L 代表取代基，如卤素原子；R 代表具有 1 或 2 个碳原子的取代或未取代的亚 烷基；M 代表碱金属阳离子或类似物，但 L 和 -R-OCH2BF3M 分别位于芳香环上相邻的碳原子上，或在芳香环熔合的情况下，位于熔合位 置上相邻一个碳原子的两个碳原子上)。