methoxy-acetic acid ; silver salt | 13126-86-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methoxy-acetic acid ; silver salt
• 英文别名: Methoxy-essigsaeure; Silbersalz；Silver;2-methoxyacetate
• CAS: 13126-86-8
• 化学式: Ag*C₃H₅O₃
• 分子量: 196.939
• InChiKey: IIYFPIRSWOMVFL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.62
• 重原子数：
  7.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  49.36
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (tri-n-butylphosphine)gold(I) chloride 、 methoxy-acetic acid ; silver salt 以 甲苯 为溶剂， 反应 12.0h， 以82%的产率得到[AuO₂CCH₂OMe(PⁿBu₃)]
  参考文献：
  名称：

  Gold(I) carboxylates and [Au(C(NH2)2(=S))2][SO3Me] for the deposition of gold and gold-doped SiOX materials by the atmospheric pressure combustion CVD process

  摘要：

  Complexes [AuO2CCH2OMe(PR3)] (3a, R = Et; 3b, R = Bu-n) were prepared by the reaction of [AuCl(PR3)] (1a, R = Et; 1b, R = Bu-n) with [AgO2CCH2OMe] (2), while [Au(C(NH2)(2) (= S))(2)][SO3Me] (4) was synthesized by electrolysis of Au in presence of thiourea in an aqueous solution of methanesulfonic acid. The thermal behavior of 3a,b and 4 was investigated by thermogravimetry (TG), displaying that 3a,b decompose in a single step, which contrasts the three-step decomposition of 4. TG-MS coupled experiments (MS = mass-spectrometry) were performed with 3b, proving that at first decarboxylation occurs, which is evidenced by the detection of CO2+. Complexes 3a,b and 4 were applied as CCVD (combustion chemical vapor deposition) precursors for the formation of gold deposits and gold-doped SiOx materials in presence of hexamethyldisiloxane (HMDSO) on silicon and glass substrates. In the combined depositions of gold and SiOx, 3a,b gave a granulated surface morphology, whereby samples deposited from 4 and HMDSO showed a porous structure as evidenced by SEM (scanning electron microscopy). The gold deposits exhibit separated particles at the substrate surface, whereof the sample deposited from 4 showed the highest amount of gold (3a,b, 3.8 at-% Au; 4, 13.3 at-% Au) as proven by XPS (X-ray photoelectron spectroscopy). The Au content of the appropriate SiOx:Au materials amounts to 1.2 at-%. XPS detail spectra of the Au 4f peaks confirm the predominant formation of Au(0) next to Au2O3. XPS depth profile measurements of the SiOx:Au samples confirmed a higher gold content when precursor 4 was applied instead of 3a,b. The as-deposited samples were used in heterogeneous catalysis for the reduction of 4-nitrophenol to 4-aminophenol with NaBH4, whereby the ones deposited from 4 (with and without a SiOx matrix) show the highest catalytic activity.

  DOI：

  10.1016/j.ica.2019.119355
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 tin 作用下， 生成 methoxy-acetic acid ; silver salt
  参考文献：
  名称：

  Meisenheimer; Schwarz, Chemische Berichte, 1906, vol. 39, p. 2551

  摘要：

  DOI：

文献信息

• Gold nanoparticles generated by thermolysis of “all-in-one” gold(i) carboxylate complexes
  作者：A. Tuchscherer、D. Schaarschmidt、S. Schulze、M. Hietschold、H. Lang

  DOI：10.1039/c2dt11748g

  日期：——

  that Au NP are formed with a size of 3.3 (±0.6) to 6.5 (±0.9) nm in p-xylene with a sharp size distribution. Additionally, a decomposition mechanism determined by TG-MS coupling experiments of the gold(I) precursors is reported showing that 1st decarboxylation occurs followed by the cleavage of the Au–PPh3 bond and finally release of ethylene glycol fragments to give Au–NP and the appropriate organics

  报道了连续制备金（I）羧酸盐[（Ph 3 P）AuO 2 CCH 2（OCH 2 CH 2）n OCH 3 ]（n = 0–6）（6a–g）的合成方法，从而具有选择性二醇HO（CH 2 CH 2 O）n H（n = 0-6）的单烷基化，Williamson醚合成和金属羧酸盐（Ag，Au）的形成是关键步骤。6a（n = 0）和6b（n的单晶X射线衍射研究= 1）表明P–Au–O单元基本上是线性的。这些化合物通过热诱导分解过程应用于金纳米颗粒（NP）的形成，因此不需要分别添加任何其他稳定剂和还原剂。提供多种捐赠能力的乙二醇官能团能够稳定封装的金胶体。讨论了浓度，生成时间和乙二醇链长对NP尺寸和尺寸分布的依赖性。通过TEM，UV / Vis光谱和电子衍射研究对金胶体进行表征，发现金纳米颗粒的形成尺寸为3.3（±0.6）至6.5（±0.9）nm。对二甲苯具有清晰的尺寸分布。此外，据报道，通过TG-
• Platinum(II) Complexes with 1,10-Phenanthroline and Hydrophilic Alkoxyacetate Ligands as Potential Antitumor Agents
  作者：Yanyan Sun、Huaixin Wei、Qiang Zhang、Xin Zhao

  DOI：10.1002/cbdv.201800373

  日期：2019.1

  Four platinum complexes, formulated as [Pt(phen)(OCOCH2 OR)2 ] (phen=1,10-phenanthroline, R=Me, Et, i Pr, or t Bu), have been synthesized and well characterized by elemental analysis, IR, 1 H-NMR, 13 C-NMR and ESI-MS spectroscopy. Replacing chloride groups of the precursor Pt(phen)Cl2 with alkoxyacetate anions greatly improved the aqueous solubility and cytotoxicity of the resulting platinum complexes

  已合成了四种配位为[Pt（phen）（OCOCH2 OR）2]（phen = 1,10-菲咯啉，R = Me，Et，i Pr或t Bu）的铂配合物，并通过元素分析对其进行了很好的表征， IR，1 H-NMR，13 C-NMR和ESI-MS光谱。用烷氧基乙酸根阴离子取代前体Pt（phen）Cl2的氯基，大大改善了所得铂配合物的水溶性和细胞毒性。体外细胞毒性研究显示，复合物1-3在体外对四种人类肿瘤细胞系具有活性，尤其是复合物1，其对HCT-116细胞系表现出与顺铂和奥沙利铂相当的显着的体外细胞毒活性。流式细胞仪检测表明，代表性的复合物1和2通过诱导S或G2 / M期细胞凋亡并阻断细胞周期进程，对HCT-116细胞系产生了细胞毒性。通过琼脂糖凝胶电泳测试了代表性复合物与pET28a质粒DNA的相互作用，结果表明复合物1和2能够通过共价结合和降解作用扭曲质粒DNA。
• Bis(phosphine) Pd(II) and Pt(II) ethylene glycol carboxylates: Synthesis, nanoparticle formation, catalysis
  作者：Sebastian Scharf、Sebastian Notz、Janine Jeschke、Andrea Preuß、Tobias Rüffer、Alexander Wiese、Andy Künzel-Tenner、Steffen Schulze、Michael Hietschold、Heinrich Lang

  DOI：10.1016/j.poly.2022.116245

  日期：2023.2

  produced M(0), while in solution (4f) narrow-sized Pd nanoparticles (=NPs) of size 2(±1)–4(±1) nm were formed as confirmed by TEM and XRD studies. Complex 5f produced uniform Pt NPs of a broader size distribution (2(±1)–8(±1) nm). The use of the Pt NPs in the hydrosilylation of PhCCH with HSiR3 (R = Et, Ph) displayed minor catalytic activity, while the Pd NP possesses good performance in the Suzuki-Miyaura

  [M(O 2 CCH 2 (OCH 2 CH 2 ) n OMe) 2 (PR 3 ) 2 ] (M = Pd: R = Ph, 4a , n = 0; 4b , n = 1; 4c , n = 2. R = Bu, 4d , n = 0; 4e , n = 1; 4f , n = 2. M = Pt: R = Ph, 5a , n = 0; 5b , n = 1; 5c , n = 2 . R = Bu, 5d , n = 0; 5e , n = 1; 5f , n = 2) 通过 [MCl 2 (PR 3 ) 2的反应]（M = Pd：1a，R = Ph；1b，R = Bu。M = Pt：2a，R = Ph；2b，R = Bu）与 [AgO 2 CCH 2（OCH 2 CH 2）n OMe）] ( 3a , n = 0; 3b , n = 1; 3c , n = 2) 以1:2的比例进行讨论。4b