Palladium-Catalyzed Coupling of Naphthoquinone Triflates with Stannanes. Unprecedented Nucleophilic Aromatic Substitution on a Hydroxynaphthoquinone Triflate
General Methodology for the Preparation of Unsymmetrical α-Linked Bisenones via Ligandless Cross-Coupling Reactions
作者:David R. Williams、Seth A. Bawel
DOI:10.1021/acs.orglett.7b00497
日期:2017.4.7
A stereocontrolled Stillecross-coupling reaction, involving the use of Pd2dba3, provides a general procedure for the synthesis of unsymmetrical α-linked bisenone systems. The transformation is achieved in the absence of phosphine ligands under conditions that promote the stabilization of “ligandless” palladium catalysis. The extension of these studies illustrates Suzuki–Miyaura reactions of 2-bor