[4-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]methyl 2-bromo-2-methylpropanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]methyl 2-bromo-2-methylpropanoate
• 英文别名: [4-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]methyl 2-bromo-2-methylpropanoate
• 化学式: C₂₅H₃₅N₄O₉Pol
• 分子量: 531.4
• InChiKey: NIBQIHZVRRGIBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  33
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  107
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  [4-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]methyl 2-bromo-2-methylpropanoate 、 1-氨基-11-叠氮-3,6,9-三氧杂十一烷 在 N-羟基丁二酰亚胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Liquid-Phase Synthesis of Block Copolymers Containing Sequence-Ordered Segments

  摘要：

  Monodisperse sequence-defined oligomers have been synthesized in solution in the absence of protecting groups. These structures have been prepared stepwise using two consecutive chemoselective reactions: 1,3-dipolar cycloaddition of terminal alkynes and azides and amidification of carboxylic acids with primary amines. These oligomers were efficiently constructed on either a conventional solid support (commercial Wang resin) or tailor-made soluble polystyrene supports synthesized by atom-transfer radical polymerization. The latter approach was found to be very versatile. Indeed, well-defined soluble macromolecular supports allowed not only the synthesis and cleavage of defined oligomers (i.e., sacrificial support) but also the preparation of noncleavable block Copolymers containing sequence-defined segments.

  DOI：

  10.1021/ja903635y
• 作为产物：
  描述：

  6-庚炔酸 、 在 4,4'-二壬基-2,2'-联吡啶 、 copper(I) bromide 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 [4-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]phenyl]methyl 2-bromo-2-methylpropanoate
  参考文献：
  名称：

  Liquid-Phase Synthesis of Block Copolymers Containing Sequence-Ordered Segments

  摘要：

  Monodisperse sequence-defined oligomers have been synthesized in solution in the absence of protecting groups. These structures have been prepared stepwise using two consecutive chemoselective reactions: 1,3-dipolar cycloaddition of terminal alkynes and azides and amidification of carboxylic acids with primary amines. These oligomers were efficiently constructed on either a conventional solid support (commercial Wang resin) or tailor-made soluble polystyrene supports synthesized by atom-transfer radical polymerization. The latter approach was found to be very versatile. Indeed, well-defined soluble macromolecular supports allowed not only the synthesis and cleavage of defined oligomers (i.e., sacrificial support) but also the preparation of noncleavable block Copolymers containing sequence-defined segments.

  DOI：

  10.1021/ja903635y

文献信息

• Liquid-Phase Synthesis of Block Copolymers Containing Sequence-Ordered Segments
  作者：Sebastian Pfeifer、Zoya Zarafshani、Nezha Badi、Jean-François Lutz

  DOI：10.1021/ja903635y

  日期：2009.7.8

  Monodisperse sequence-defined oligomers have been synthesized in solution in the absence of protecting groups. These structures have been prepared stepwise using two consecutive chemoselective reactions: 1,3-dipolar cycloaddition of terminal alkynes and azides and amidification of carboxylic acids with primary amines. These oligomers were efficiently constructed on either a conventional solid support (commercial Wang resin) or tailor-made soluble polystyrene supports synthesized by atom-transfer radical polymerization. The latter approach was found to be very versatile. Indeed, well-defined soluble macromolecular supports allowed not only the synthesis and cleavage of defined oligomers (i.e., sacrificial support) but also the preparation of noncleavable block Copolymers containing sequence-defined segments.