N,N-phthaloyl-thioglycine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N,N-phthaloyl-thioglycine
• 英文别名: N,N-Phthaloyl-thioglycin；2-(1,3-dioxoisoindol-2-yl)ethanethioic S-acid
• 化学式: C₁₀H₇NO₃S
• 分子量: 221.236
• InChiKey: HQLBHKAORZSOEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻苯二甲酰甘氨酸 在 二氯甲烷 、 氯甲酸乙酯 、 三乙胺 作用下， 生成 N,N-phthaloyl-thioglycine
  参考文献：
  名称：

  A NEW METHOD FOR THE PREPARATION OF THIO ACIDS AND APPLICATION TO PEPTIDE CHEMISTRY

  摘要：

  DOI：

  10.1021/ja01138a527

文献信息

• THE SYNTHESIS AND REACTIONS OF N-ACYL THIOL AMINO ACIDS
  作者：John C. Sheehan、David A. Johnson

  DOI：10.1021/ja01138a528

  日期：1952.9
• Inhibitors of Dna Methylation in Tumor Cells
  申请人：Garcia Boy Regine

  公开号：US20080138329A1

  公开（公告）日：2008-06-12

  The present invention relates to compounds according to the general formula wherein the dotted lines denote a single bond which is optionally present, with 2 dotted lines denoting a double bond; wherein, in case no double bond is present and a free valence exists, this valence is occupied by H; and wherein the symbols have the meanings defined in the text, or a pharmaceutically acceptable salt thereof, and which lend themselves for the manufacture of drugs useful in the inhibtion of DNA methylation, the inhibition of DNA methyltransferases, and may therefore be useful for the manufacture of pharmaceuticals for the treatment of developmental disorders such as Prader-Willi-Syndrome, Angelman-Syndrome (Happy Puppet Syndrome), Beckwith-Wiedemann-Syndrome, and proliferative diseases, such as coronary restenosis and neoplastic diseases, particularly colon carcinoma, familiary adenomatous polyposis carcinoma and hereditary non-polyposis colorectal cancer, prostate carcinoma, melanoma, non-Hodgkin lymphoma, acute lymphatic leukemia (ALL), chronic lymphatic leukemia (CLL), acute myeolid leukemia (AML), chronic myeloid leukemia (CML), or hepatocellular carcinoma. These compounds may also be used for other applications including the induction of cellular differentiation, diagnosis, and the use in screening assays.
• A NEW METHOD FOR THE PREPARATION OF THIO ACIDS AND APPLICATION TO PEPTIDE CHEMISTRY
  作者：Marshall W. Cronyn、James Jiu

  DOI：10.1021/ja01138a527

  日期：1952.9