1,6-bis-butyryloxy-hexane | 6222-19-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1,6-bis-butyryloxy-hexane
• 英文别名: 1,6-Bis-butyryloxy-hexan；Hexane-1,6-diyl dibutanoate；6-butanoyloxyhexyl butanoate
• CAS: 6222-19-1
• 化学式: C₁₄H₂₆O₄
• 分子量: 258.358
• InChiKey: QVTMHQILPALTKK-UHFFFAOYSA-N

物化性质

• 沸点：
  122 °C(Press: 1 Torr)
• 密度：
  0.969±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,6-己二醇 、 正丁醛 在 六甲基磷酰三胺 、 溴 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 以94%的产率得到1,6-bis-butyryloxy-hexane
  参考文献：
  名称：

  Br 2 -HMPT-NaHCO 3将醇与醛进行新的氧化酯化反应。

  摘要：

  描述了在碳酸氢钠存在下使用溴/ HMPT络合物进行的新的醛介导的氧化酯化反应。

  DOI：

  10.1016/0040-4039(90)80204-y

文献信息

• Convenient Selective Monoacylation of 1,n-Diols Catalyzed by Ion-Exchange Resins
  作者：Takeshi Nishiguchi、Shizuo Fujisaki、Yasuhiro Ishii、Yoshihiro Yano、Akiko Nishida

  DOI：10.1021/jo00084a043

  日期：1994.3

  Several 1,n-diols, ranging from 1,2-ethanediol to 1,16-hexadecanediol, were selectively monoacylated by transesterification in ester/octane solvent mixtures catalyzed by strongly acidic ion-exchange resins. This method of selective esterification is quite simple and practical. The selectivity for monoester formation and initial rates of monoester formation depended on the ester/octane ratio of the solvents. The reasons for the selectivity are as follows: (1) The sulfonic acid-type ion-exchange resins usually contain 50-80% water, and a strongly acidic aqueous layer is formed on the surface of the resins. (2) A partition equilibrium between the aqueous layer and the aprotic ester/octane layer is setup, and diols have higher partition coefficients than the product monoesters. (3) Acylation of the alcohols occurs in the aqueous layer and/or at the interface between the aqueous and the nonaqueous liquid layer. (4) The formed monoesters move away from the aqueous layer into the aprotic layer.
• NEIRABEYEH, MAMDOUH AL.;PUJOL, M. DOLORS, TETRAHEDRON LETT., 31,(1990) N6, C. 2273-2276
  作者：NEIRABEYEH, MAMDOUH AL.、PUJOL, M. DOLORS

  DOI：——

  日期：——
• STABILIZED HIGH-DENSITY POLYETHYLENE COMPOSITION WITH IMPROVED RESISTANCE TO DETERIORATION AND STABILZER SYSTEM
  申请人：Equistar Chemicals LP

  公开号：EP2917276B1

  公开（公告）日：2018-07-18
• CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF
  申请人：Anderson Daniel Griffith

  公开号：US20080145338A1

  公开（公告）日：2008-06-19

  Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
• End-Modified Poly(beta-amino esters) and Uses Thereof
  申请人：Zugates Gregory T.

  公开号：US20080242626A1

  公开（公告）日：2008-10-02

  Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.