2-肼基-1,4,5,6-四氢嘧啶氢溴酸 | 197234-18-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-肼基-1,4,5,6-四氢嘧啶氢溴酸
• 中文别名: 1,4,5,6-四氢嘧啶-2-基肼氢溴酸盐；2-肼基-1,4,5,6-四氢吡啶
• 英文名称: 2-hydrazine-1,4,5,6-tetrahydropyrimidine hydrobromide
• 英文别名: 2-hydrazino-1,4,5,6-tetrahydropyrimidine hydrobromide；1,4,5,6-tetrahydropyrimidin-2-ylhydrazine;hydrobromide
• CAS: 197234-18-7
• 化学式: BrH*C₄H₁₀N₄
• mdl: MFCD00053056
• 分子量: 195.062
• InChiKey: GCCPFVFSVPYXQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.08
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  62.4
• 氢给体数：
  4
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  1-[(4-甲基苯基)磺酰]-1H-吲哚-3-甲醛 、 2-肼基-1,4,5,6-四氢嘧啶氢溴酸 在 盐酸 作用下， 以 水 、 异丙醇 为溶剂， 反应 2.0h， 以42%的产率得到1-[(4-methylphenyl)sulfonyl]-1H-indole-3-carbaldehyde 1,4,5,6-tetrahydropyrimidin-2-ylhydrazone
  参考文献：
  名称：

  Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands

  摘要：

  本发明提供了一种公式I的化合物，以及该化合物用于治疗与5-HT6受体相关或受其影响的疾病。

  公开号：

  US20040002527A1

文献信息

• Tricyclic compounds, preparation method and said method intermediates, application as medicines and pharmaceutical compositions containing same
  申请人：Aventis Pharma S.A.

  公开号：US06339082B1

  公开（公告）日：2002-01-15

  A compound selected from the group consisting of a compound of the formula wherein the substituents are defined as set forth in the specification and its salts with non-toxic pharmaceutically acceptable acids and bases useful for treating loss of bone matrix.

  从以下公式中选择的化合物，其中取代基如规范中所述，并且其盐与非毒性药用可接受酸和碱有用于治疗骨基质丢失的化合物。
• Trani; Bellasio, Farmaco, Edizione Scientifica, 1983, vol. 38, # 12, p. 940 - 949
  作者：Trani、Bellasio

  DOI：——

  日期：——
• Bis-Cationic Heteroaromatics as Macrofilaricides:  Synthesis of Bis-Amidine and Bis<i>-</i>Guanylhydrazone Derivatives of Substituted Imidazo[1,2-<i>a</i>]pyridines
  作者：Richard J. Sundberg、Sujay Biswas、Krishna Kumar Murthi、Donna Rowe、John W. McCall、Michael T. Dzimianski

  DOI：10.1021/jm9803368

  日期：1998.10.1

  A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo[1,2-a]pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds. Compounds with 4',6-bis-substitution by cyclic guanylhydrazone groups show activity. 4',6-Bis-amidines show some activity but are more toxic; 4'- or 6-monosubstituted compounds are inactive. 2,6-Bis-substituted compounds lacking the phenyl ring are inactive. 4',6-Bis-substituted compounds having additional double bonds inserted between the heterocyclic ring and the phenyl ring or between the substituent and the ring system show reduced activity.
• Heber; Herzig; Moosig, Pharmazie, 1995, vol. 50, # 10, p. 663 - 667
  作者：Heber、Herzig、Moosig、Neujahr

  DOI：——

  日期：——
• TRANI, A.;BELLASIO, E., FARMACO. ED. SCI., 1983, 38, N 12, 940-949
  作者：TRANI, A.、BELLASIO, E.

  DOI：——

  日期：——