7-p-methoxyphenyl-2-p-methoxyphenylmethylene-8,9-diazabicyclo[4.3.0]non-9-ene | 57770-87-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 7-p-methoxyphenyl-2-p-methoxyphenylmethylene-8,9-diazabicyclo[4.3.0]non-9-ene
• 英文别名: (3S,3aR,7E)-3-(4-methoxyphenyl)-7-[(4-methoxyphenyl)methylidene]-2,3,3a,4,5,6-hexahydroindazole
• CAS: 57770-87-3
• 化学式: C₂₂H₂₄N₂O₂
• 分子量: 348.445
• InChiKey: HTZQXAXBAZEFHK-BPENLDBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  42.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-p-methoxyphenyl-2-p-methoxyphenylmethylene-8,9-diazabicyclo[4.3.0]non-9-ene 以 氯仿 为溶剂， 反应 0.08h， 生成 2-acetyl-3-(4-methoxyphenyl)-7-[4-methoxyphenyl-(4-phenyl-1-urazolyl)methyl]-3,4,5,9-tetrahydro-2H-indazole
  参考文献：
  名称：

  芳基亚甲基二氢吡唑与 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione 的烯反应

  摘要：

  2-Acetyl-3-aryl-7-arylmethylene-3,4,5,6,7,9-hexahydro-2H-吲唑与 4-phenyl-3H-1,2,4-triazole-3 发生烯反应,5(4H)-二酮得到相应的单烯加合物。在类似条件下。3-aryl-7-arymethylene-2-methyl-3,4,5,6,7,9-hexahydro-2H-吲唑产生单加成和加聚产物。使用UV、IR、1 H和1 3 C NMR光谱和X射线衍射分析确定所得化合物的结构。

  DOI：

  10.1055/s-2002-33917
• 作为产物：
  描述：

  (2E,6E)-2,6-bis(4-methoxybenzylidene)cyclohexanone 在 一水合肼 作用下， 以 乙醇 为溶剂， 以72%的产率得到7-p-methoxyphenyl-2-p-methoxyphenylmethylene-8,9-diazabicyclo[4.3.0]non-9-ene
  参考文献：
  名称：

  芳基亚甲基二氢吡唑与 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione 的烯反应

  摘要：

  2-Acetyl-3-aryl-7-arylmethylene-3,4,5,6,7,9-hexahydro-2H-吲唑与 4-phenyl-3H-1,2,4-triazole-3 发生烯反应,5(4H)-二酮得到相应的单烯加合物。在类似条件下。3-aryl-7-arymethylene-2-methyl-3,4,5,6,7,9-hexahydro-2H-吲唑产生单加成和加聚产物。使用UV、IR、1 H和1 3 C NMR光谱和X射线衍射分析确定所得化合物的结构。

  DOI：

  10.1055/s-2002-33917

文献信息

• Khalaf, Ali Ali; El-Shafei, Ahmed Kamal; El-Sayed, Ahmed Mahmoud, Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 609 - 612
  作者：Khalaf, Ali Ali、El-Shafei, Ahmed Kamal、El-Sayed, Ahmed Mahmoud

  DOI：——

  日期：——
• ——
  作者：M. G. Martinez、T. Klimova-Berestneva、K. Damian-Zea、N. N. Meleshonkova、E. I. Klimova

  DOI：10.1023/a:1020771320485

  日期：——

  8-Acetyl-7-aryl-2-arylmethylene-8,9-diaza- and 4,8,9-triazabicyclo[4.3.0]non-9-enes react with 4-phenyl-4,5-dihydro-3H-1,2,4-triazole-3,5-dione, following the ene addition pattern. Under similar conditons 7-aryl-2-arylmethylene-8-methyl-8,9-diazabicyclo[4.3.0]non-9-enes give rise to both mono- and polyaddition products. The product structures were studied by H-1 and C-13 NMR, IR, and UV spectroscopy and single crystal X-ray diffraction.
• Ene Reactions of Arylmethylenedihydropyrazoles with 4-Phenyl-3<i>H</i>-1,2,4-triazole-3,5(4<i>H</i>)-dione
  作者：G. Martinez、E. Klimova、B. Klimova、Z. Damian、S. Ortega、I. Mendez、P. Gutiérrez、G. Vazquez

  DOI：10.1055/s-2002-33917

  日期：——

  2-Acetyl-3-aryl-7-arylmethylene-3,4,5,6,7,9-hexahydro-2H-indazoles enter into the ene reaction with 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione to give the corresponding monoene adducts. Under analogous conditions. 3-aryl-7-arymethylene-2-methyl-3,4,5,6,7,9-hexahydro-2H-indazoles give mono- and polyaddition products. The structures of compounds obtained were established using UV, IR, 1 H and 1 3 C NMR

  2-Acetyl-3-aryl-7-arylmethylene-3,4,5,6,7,9-hexahydro-2H-吲唑与 4-phenyl-3H-1,2,4-triazole-3 发生烯反应,5(4H)-二酮得到相应的单烯加合物。在类似条件下。3-aryl-7-arymethylene-2-methyl-3,4,5,6,7,9-hexahydro-2H-吲唑产生单加成和加聚产物。使用UV、IR、1 H和1 3 C NMR光谱和X射线衍射分析确定所得化合物的结构。