Enantioselectivity in the reduction of tricyclic hydroaromatic ketones by baker's yeast
作者:Gabriele Fontana、Paolo Manitto、Giovanna Speranza、Simona Zanzola
DOI:10.1016/s0957-4166(98)00111-6
日期:1998.4
Three benzo-2-tetralones were hydrogenated to the corresponding alcohols by non-fermenting baker's yeast. Satisfactory yields but modest enantioselectivities were observed. The prevalent enantioform of the benzo-2-tetralol was found to be in agreement with the predictive abstract model previously proposed for the enzymatic hydrogenation of aromatic ring substituted 2-tetralones.
通过非发酵面包酵母将三种苯并-2-四氢萘酮氢化为相应的醇。令人满意的产率,但是观察到适度的对映选择性。发现苯并-2-戊醇的普遍对映体与先前提出的用于芳香环取代的2-四氢萘酮的酶促氢化的预测抽象模型相符。