7-hydroxycoumarin potassium salt | 142044-47-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-hydroxycoumarin potassium salt
• 英文别名: potassium salt of umbelliferone；7-hydroxycoumarin potassium；umbelliferone potassium salt；Potassium;2-oxochromen-7-olate
• CAS: 142044-47-1
• 化学式: C₉H₅O₃*K
• 分子量: 200.235
• InChiKey: NDXUSSRPHFJPHE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.13
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-(iodomethyl)phenoxy)triisopropylsilane 、 7-hydroxycoumarin potassium salt 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以45%的产率得到7-(2-(triisopropylsilyloxy)benzyloxy)-2H-chromen-2-one
  参考文献：
  名称：

  Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?

  摘要：

  A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.

  DOI：

  10.1021/ol900433g
• 作为产物：
  描述：

  7-羟基香豆素 以 甲醇 、 苯 为溶剂， 生成 7-hydroxycoumarin potassium salt
  参考文献：
  名称：

  Reagents for the quantitation of active oxygen

  摘要：

  化合物通式（I）或（II）或其盐，以及用于测量反应性氧化物的试剂，包括该化合物或其盐：1其中，R1和R2分别表示可以被取代的芳基基团，例如，取代有氨基或羟基的苯基基团，R3表示可以被取代的2-羧基苯基基团。

  公开号：

  US20030153027A1

文献信息

• THE ASYMMETRIC DIELS–ALDER REACTIONS OF α,β-UNSATURATED CARBOXYLIC AMIDES DERIVED FROM (−)-PHENYLGLYCINOL AND THE ASYMMETRIC TOTAL SYNTHESIS OF (+)-FARNESIFEROL C
  作者：Teruaki Mukaiyama、Nobuharu Iwasawa

  DOI：10.1246/cl.1981.29

  日期：1981.1.5

  The asymmetric intramolecular Diels–Alder reactions of α,β-unsaturated carboxylic amides derived from (−)-phenylglycinol were studied and successfully applied to the asymmetric total synthesis of (+)-farnesiferol C.

  研究了衍生自 (-)-苯基甘氨醇的 α,β-不饱和羧酸酰胺的不对称分子内 Diels-Alder 反应，并成功应用于 (+)-farnesiferol C 的不对称全合成。
• Self-Immolative Phthalate Esters Sensitive to Hydrogen Peroxide and Light
  作者：Kaitlyn M. Mahoney、Pratik P. Goswami、Aleem Syed、Patrick Kolker、Brian Shannan、Emily A. Smith、Arthur H. Winter

  DOI：10.1021/jo501900h

  日期：2014.12.5

  Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7-hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro-fluorophore in cultured S2 cells.

  将自焚的邻苯二甲酸芳基酯与对光和过氧化氢敏感的可裂解的掩蔽基团缀合。邻苯二甲酸酯连接基分别暴露于光或H 2 O 2时释放荧光染料7-羟基香豆素，从而导致荧光增强。在培养的S2细胞中，邻苯二甲酸酯基芳基酯被证明是一种前荧光团。
• Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?
  作者：Ho Yong Lee、Xuan Jiang、Dongwhan Lee

  DOI：10.1021/ol900433g

  日期：2009.5.21

  A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.
• Reagents for the quantitation of active oxygen
  申请人：——

  公开号：US20030153027A1

  公开（公告）日：2003-08-14

  A compound represented by general formula (I) or (II) or a salt thereof and an agent for measurement of a reactive oxygen comprising said compound or a salt thereof: 1 wherein R 1 and R 2 independently represent an aryl group which may be substituted, e.g., a phenyl group substituted with an amino group or a hydroxy group, and R 3 represents a 2-carboxyphenyl group which may be substituted.

  化合物通式（I）或（II）或其盐，以及用于测量反应性氧化物的试剂，包括该化合物或其盐：1其中，R1和R2分别表示可以被取代的芳基基团，例如，取代有氨基或羟基的苯基基团，R3表示可以被取代的2-羧基苯基基团。