1-methyl-2-methylene-1,2-dihydro-pyridine | 23707-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-methyl-2-methylene-1,2-dihydro-pyridine
• 英文别名: 1-Methyl-2-methylen-1,2-dihydro-pyridin；2-Methylen-1-methyl-1,2-dihydro-pyridin；1-Methyl-2-pyridinmethid；N-methyl-2-methylidenepyridine；1-methyl-2-methylidenepyridine
• CAS: 23707-43-9
• 化学式: C₇H₉N
• 分子量: 107.155
• InChiKey: RUVAZGFWJWRCJL-UHFFFAOYSA-N

物化性质

• 沸点：
  176.1±13.0 °C(Predicted)
• 密度：
  0.94±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-methyl-2-methylene-1,2-dihydro-pyridine 、 5-乙氧基甲烯基-2,2-二甲基-1,3-二氧六环-4,6-二酮 以 甲苯 为溶剂， 反应 336.0h， 以5%的产率得到5-<2-(1-methyl-2(1H)pyridyliden)ethyliden>-2,2-dimethyl-1,3-dioxan-4,6-dione
  参考文献：
  名称：

  Reactions of cyclic 1,3-dicarbonyl compounds with 1,2(1,4)-dihydro-1-methyl-2(4)-methylene-N-heterocycles. A new access to 6,12-methano-dibenz[d,g]-[1,3]oxazocinones

  摘要：

  The enamine-type methylene-N-heterocycles 1-5 react with cyclic 2-ethoxymethylene-1,3-dicarbonyl compounds 6 to give 2-[2-(hetarylidene)ethylidene]-1,3-dicarbonyl compounds 7-14. The result of the reactions between 1,2-dihydro-1-methyl-2-methylene-quinoline (Ia) and cyclic 1,3-dicarbonyl compounds depends on the nature of the dihydro intermediates A/B. Dehydrogenation of keton intermediates A results in 2-(1,2-dimethyl-4(1H)-quinolylidene)-1,3-dicarbonyl compounds 17-21. Enol intermediates B with 6-membered dicarbonyl ring form 6,12-methano-dibenz[d,g][1,3]oxazocinones 22-25. H-1 NM R spectra and X-ray structure analysis prove the structure of 23.

  DOI：

  10.1007/bf00811679
• 作为产物：
  描述：

  碘化1,2-二甲基吡啶鎓 在 氢氧化钾 作用下， 以 水 、 甲苯 为溶剂， 生成 1-methyl-2-methylene-1,2-dihydro-pyridine
  参考文献：
  名称：

  Reactions of cyclic 1,3-dicarbonyl compounds with 1,2(1,4)-dihydro-1-methyl-2(4)-methylene-N-heterocycles. A new access to 6,12-methano-dibenz[d,g]-[1,3]oxazocinones

  摘要：

  The enamine-type methylene-N-heterocycles 1-5 react with cyclic 2-ethoxymethylene-1,3-dicarbonyl compounds 6 to give 2-[2-(hetarylidene)ethylidene]-1,3-dicarbonyl compounds 7-14. The result of the reactions between 1,2-dihydro-1-methyl-2-methylene-quinoline (Ia) and cyclic 1,3-dicarbonyl compounds depends on the nature of the dihydro intermediates A/B. Dehydrogenation of keton intermediates A results in 2-(1,2-dimethyl-4(1H)-quinolylidene)-1,3-dicarbonyl compounds 17-21. Enol intermediates B with 6-membered dicarbonyl ring form 6,12-methano-dibenz[d,g][1,3]oxazocinones 22-25. H-1 NM R spectra and X-ray structure analysis prove the structure of 23.

  DOI：

  10.1007/bf00811679

文献信息

• CYTOKINE INHIBITORS
  申请人：Deng Wei

  公开号：US20090118292A1

  公开（公告）日：2009-05-07

  A compound of Formula I: Each variable is defined in the specification. This invention relates to a method of decreasing a level of a cytokine (e.g., TNFα or interlukine such as IL-1β) in a subject with a compound of Formula I. It also relates to a method of treating a disorder mediated by an overproduction of a cytokine with such a compound.

  一种化合物的化学式为I：每个变量在说明书中有定义。本发明涉及一种使用化合物I降低受试者体内细胞因子水平（如TNFα或诸如IL-1β的白细胞介素）的方法。它还涉及一种使用这种化合物治疗由细胞因子过度产生引起的疾病的方法。
• [EN] [1,3]DIAZINO[5,4-d]PYRIMIDINES AS HER2 INHIBITORS<br/>[FR] [1,3]DIAZINO[5,4-D]PYRIMIDINES EN TANT QU'INHIBITEURS DE HER2
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2021213800A1

  公开（公告）日：2021-10-28

  The present invention relates to new [1,3]diazino[5,4-d]pyrimidines and derivatives of Formula (I), wherein the groups R1, R2, R3 and R4 have the meanings given in the claims and specification, their use as inhibitors of HER2 and its mutants, pharmaceutical compositions which contain such compounds and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

  本发明涉及新的[1,3]二氮杂[5,4-d]嘧啶及其衍生物的化合物，其化学式为(I)，其中基团R1，R2，R3和R4的含义如权利要求和说明书所述，其用作HER2及其突变体的抑制剂，包含这类化合物的制药组合物以及其用作药物，特别是用作治疗和/或预防肿瘤性疾病的药物。
• Substituted mesoionic compounds for combating animal pests
  申请人：BASF SE

  公开号：EP2684879A1

  公开（公告）日：2014-01-15

  A substituted mesoionic compound of formula (I), wherein the symbols have the meanings as given in the description, is useful for combating animal pests.

  公式（I）的取代中间离子化合物，在符号所给出的含义下，对于防治动物害虫是有用的。
• Nitrogen containing heterocyclic compounds and medicines containing the same
  申请人：Ozaki Fumihiro

  公开号：US20070293496A1

  公开（公告）日：2007-12-20

  Compounds represented by the following general formula: [wherein X 1 , X 2 , X 3 and X 4 each independently represent a single bond, C 1-6 alkylene, etc.; A 2 represents optionally substituted phenyl, etc.; A 1 represents an optionally substituted 5- to 7-membered heterocyclic group containing —C(=Q 1 )- (wherein Q 1 represents oxygen, sulfur or ═N—R 11 (wherein R 11 represents hydrogen or C 1-6 alkyl)) and nitrogen, etc.; and Z 1 represents piperidin-diyl, etc.], salts thereof and hydrates of the foregoing.

  以下一般式所代表的化合物：[其中X1、X2、X3和X4各自独立地代表单键、C1-6烷基等；A2代表可选取代的苯基等；A1代表可选取代的5-至7-成员杂环基，其中包含—C（=Q1）-（其中Q1代表氧、硫或═N—R11（其中R11代表氢或C1-6烷基））和氮等；Z1代表哌啶基等]，其盐和水合物。
• Hydroxamic Esters as Photoinitiators
  申请人：Casiraghi Angelo

  公开号：US20100093883A1

  公开（公告）日：2010-04-15

  The present invention concerns photopolymerisable systems comprising reactive oligomers and/or monomers having ethylenically unsaturated groups and as photoinitiator at least one hydroxamic ester of Formula (I) or (II) or (III).

  本发明涉及光聚合系统，包括具有乙烯基不饱和基团的反应性寡聚物和/或单体，以及至少一种式（I）或（II）或（III）的羟胺酯作为光引发剂。