4-溴噻吩-3-胺 | 161833-43-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 中文名称: 4-溴噻吩-3-胺
• 英文名称: 3-amino-4-bromothiophene
• 英文别名: 4-Bromothiophen-3-amine
• CAS: 161833-43-8
• 化学式: C₄H₄BrNS
• 分子量: 178.052
• InChiKey: WHEAUTZIPHKMDS-UHFFFAOYSA-N

物化性质

• 沸点：
  278.0±20.0 °C(Predicted)
• 密度：
  1.828±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-溴噻吩-3-胺 、 2-(氯磺酰基)苯甲酸甲酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以59%的产率得到methyl 2-(N-(4-bromothiophen-3-yl)sulfamoyl)benzoate
  参考文献：
  名称：

  [EN] MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR
  [FR] AGONISTES DE RÉCEPTEURS D'OPIOÏDES ΜU ET LEURS UTILISATIONS

  摘要：

  本公开涉及一种具有结构式：Formula(I)或其药学上可接受的盐或酯，用于治疗或预防神经系统疾病，包括亨廷顿病、雷特综合症和CDKL5症状。

  公开号：

  WO2022074587A1
• 作为产物：
  描述：

  3-azido-4-bromothiophene 在 三甲基膦 作用下， 生成 4-溴噻吩-3-胺
  参考文献：
  名称：

  Improved Synthesis of Thienothiazole and Its Utility in Developing Polymers for Photovoltaics

  摘要：

  In response to the structural and electronic limitations of the popular benzo[1,2-b:4,5-b']dithiophene-thieno[3,4-b]thiophene (PBnDT-TT) polymer series, this study explores the design and synthesis of a thienothiazole (TTz) moiety. The synthesis of TTz was streamlined down to four high-yielding steps, resulting in the new polymer PBnDT-TTz for organic solar cells. By incorporating TTz, a nitrogen is directly introduced into the polymer backbone which tunes the HOMO level and eliminates the reliance on external substituents. Compared to its TT analogue, PBnDT-TTz exhibits the same HOMO level of -5.06 eV and the same V-oc of 0.69 eV, yet a higher power conversion efficiency of 2.5%. These promising results demonstrate the benefits of backbone modification and the great potential of TTz in the design of new polymers for organic photovoltaics.

  DOI：

  10.1021/ma201835h

文献信息

• [EN] A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS<br/>[FR] NOUVELLE CLASSE D'AGONISTES DU RÉCEPTEUR MU-OPIOÏDE
  申请人：UNIV COLUMBIA

  公开号：WO2015138791A1

  公开（公告）日：2015-09-17

  The present invention provides a compound having the structure (I) or a pharmaceutically acceptable salt or ester thereof.

  本发明提供了一种具有结构（I）的化合物或其药用可接受的盐或酯。
• Improved Synthesis of Thienothiazole and Its Utility in Developing Polymers for Photovoltaics
  作者：Rycel Uy、Liqiang Yang、Huaxing Zhou、Samuel C. Price、Wei You

  DOI：10.1021/ma201835h

  日期：2011.12.13

  In response to the structural and electronic limitations of the popular benzo[1,2-b:4,5-b']dithiophene-thieno[3,4-b]thiophene (PBnDT-TT) polymer series, this study explores the design and synthesis of a thienothiazole (TTz) moiety. The synthesis of TTz was streamlined down to four high-yielding steps, resulting in the new polymer PBnDT-TTz for organic solar cells. By incorporating TTz, a nitrogen is directly introduced into the polymer backbone which tunes the HOMO level and eliminates the reliance on external substituents. Compared to its TT analogue, PBnDT-TTz exhibits the same HOMO level of -5.06 eV and the same V-oc of 0.69 eV, yet a higher power conversion efficiency of 2.5%. These promising results demonstrate the benefits of backbone modification and the great potential of TTz in the design of new polymers for organic photovoltaics.
• [EN] MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR<br/>[FR] AGONISTES DE RÉCEPTEURS D'OPIOÏDES ΜU ET LEURS UTILISATIONS
  申请人：KURES INC

  公开号：WO2022074587A1

  公开（公告）日：2022-04-14

  The present disclosure relates to a compound having the structure: Formula (I) or a pharmaceutically acceptable salt or ester thereof, for treating or preventing a neurological disorder, including Huntington's disease, Rett syndrome, and CDKL5 disorder.

  本公开涉及一种具有结构式：Formula(I)或其药学上可接受的盐或酯，用于治疗或预防神经系统疾病，包括亨廷顿病、雷特综合症和CDKL5症状。