4-溴-2-[(5-溴-2-羟基苯基)甲基]苯酚 | 78563-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-溴-2-[(5-溴-2-羟基苯基)甲基]苯酚
• 英文名称: bis-(5-bromo-2-hydroxyphenyl)methane
• 英文别名: 5,5'-dibromo-2,2'-dihydroxy-diphenyl-methane；2,2'-methylenebis(4-bromophenol)；4,4'-dibromo-2,2'-methanediyl-di-phenol；4,4'-Dibrom-2,2'-methandiyl-di-phenol；Bis-(5-brom-2-hydroxy-phenyl)-methan；Phenol, 2,2'-methylenebis(4-bromo-；4-bromo-2-[(5-bromo-2-hydroxyphenyl)methyl]phenol
• CAS: 78563-03-8
• 化学式: C₁₃H₁₀Br₂O₂
• 分子量: 358.029
• InChiKey: FGDRHERYMWECPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-溴-2-[(5-溴-2-羟基苯基)甲基]苯酚 在 sodium 作用下， 生成 氧杂蒽
  参考文献：
  名称：

  THE STABILITY OF 2,2'-DIHYDROXYDIPHENYLMETHANE

  摘要：

  DOI：

  10.1021/jo01192a003
• 作为产物：
  描述：

  亚甲基二苯酚 在 溴 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以41%的产率得到C₁₃H₁₁BrO₂
  参考文献：
  名称：

  Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives

  摘要：

  A series of bromophenols was obtained by isolation from red alga Odonthalia corymbifera and by reactions of bis(hydroxyphenyl)methanes with bromine. New bromophenols including 3,3,5,5'-tetrabromo-2,2',4,4'-tetrahydroxydiphenylmethane (10), a regioisomer of the potent antimicrobial natural product, together with known derivatives were synthesized in high yield. All of the isolated and synthesized compounds were tested for antimicrobial activity against Gram-negative, Gram-positive bacteria and fungi. The preliminary structure-activity relationship, to elucidate the essential structure requirements for antimicrobial activity, has been described. Among the isolated natural products 2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane (4) was found to be the most active derivative against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes. The synthetic bromophenols 3,3'-dibromo-6,6'-dihydroxydiphenylmethane (13) and 3,3',5,5'-tetrabromo-6, 6'-dihydroxydiphenylmethane (14) showed potent antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus. Proteus vulgaris, and Salmonella typhimurium. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.003

文献信息

• [EN] ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF<br/>[FR] ANTAGONISTES/BLOQUEURS DES CANAUX IONIQUES ET LEURS UTILISATIONS
  申请人：SHANGHAI EAST HOSPITAL

  公开号：WO2021114313A1

  公开（公告）日：2021-06-17

  Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

  提供了离子通道拮抗剂/阻断剂及其用途。具体而言，提供了式（I）的化合物或药用盐、立体异构体、溶剂合物或前药，其制备方法及应用。每个式中的各个基团的定义可在说明书中找到详细信息。还提供了用于治疗心脏病和其他离子通道相关疾病的药物组合物。
• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• The Synthesis of 4,11,18,25-Tetrachloro [14]metacyclophane-7,14,21,28-tetroi, Structural Analogues of Phloroglucides
  作者：Ali A. Moshfegh、Rashid Badri、Massoud Hojjatie、Mehrangiz Kaviani、Basirat Naderi、Aboul H. Nazmi、Merrikh Ramezanian、Bizhan Roozpeikar、Gholam H. Haakimelahi

  DOI：10.1002/hlca.19820650411

  日期：1982.6.16

  The synthesis of the title compounds is described. Some of the compounds prepared exhibited antimicrobial activity in vitro. Structure-activity relationship is briefly discussed.

  描述了标题化合物的合成。所制备的某些化合物在体外表现出抗微生物活性。简要讨论了结构与活动的关系。
• The Synthesis of Polyfunctional Aromatic Ring Systems. Structural Analogues of Phloroglucides, Aranciamycin, Cryptosporin and Terramycin
  作者：Gholam Hosein Hakimelahi、Ali Akbar Moshfegh

  DOI：10.1002/hlca.19810640224

  日期：1981.3.18

  The synthesis of the title compounds is described. Some of the compounds prepared were found to be active against a number of pathogenic microorganisms in vitro.

  描述了标题化合物的合成。发现所制备的某些化合物在体外对多种病原微生物具有活性。
• The Synthesis of 5,11,17-Trihalotetracyclo [13.3.1.13,7.19,13]henicosa-1 (19),3,5,7 (20),9,11,13 (21), 15,17-nonaene-19,20,21-triols and 5,11,17-trihalo-19,20,21-trihydroxytetracyclo [13.3.1.13,7. 19,13]henicosa-1 (19),3,5,7 (20),9,11,13(21), 15,17-nonaene-8,14-dione [1]. Cyclo-derivatives of Phloroglucide Analogues
  作者：Ali A. Moshfegh、Effat Beladi、Lida Radnia、Afsaneh S. Hosseini、Soosan Tofigh、Gholam H. Hakimelahi

  DOI：10.1002/hlca.19820650416

  日期：1982.6.16

  The synthesis of the title compounds (1 and 3) is described. Some of the compounds prepared were found to be active against a number of pathogenic microorganisms in vitro. Structure-activity relationship is briefly discussed.

  描述了标题化合物（1和3）的合成。发现所制备的某些化合物在体外对许多病原微生物具有活性。简要讨论了结构与活动的关系。