(n-pentyl)diphenylphosphane | 77423-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (n-pentyl)diphenylphosphane
• 英文别名: diphenylpentylphosphine；(Diphenylphosphino)pentane；pentyl(diphenyl)phosphane
• CAS: 77423-29-1
• 化学式: C₁₇H₂₁P
• 分子量: 256.327
• InChiKey: NRVSCUABVKRWEH-UHFFFAOYSA-N

物化性质

• 沸点：
  346.6±11.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (n-pentyl)diphenylphosphane 在 双氧水 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以80%的产率得到[戊基(苯基)磷酰基]苯
  参考文献：
  名称：

  以酰基膦为磷源的钯催化的C（sp 3）–P（III）键形成反应

  摘要：

  开发了钯催化的C（sp 3）–P（III）键形成烷基取代的膦的制备反应。在该反应中，各种烷基溴化物和有限的烷基氯化物在相对温和且易于获得的条件下与酰基膦反应，并以高收率获得了不同的膦。该反应弥补了钯催化在C（sp 3）–P（III）键形成中的应用，并表明了酰基膦作为磷化试剂的实际应用。

  DOI：

  10.1016/j.tetlet.2020.152125
• 作为产物：
  描述：

  [戊基(苯基)磷酰基]苯 在 aluminium hydride*tetrahydrofuran 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以97%的产率得到(n-pentyl)diphenylphosphane
  参考文献：
  名称：

  Alane-还原氧化膦的新方法

  摘要：

  使用铝烷-AlH 3可以将氧化膦以优异的产率还原为膦。不需要水后处理。

  DOI：

  10.1016/s0040-4039(98)00748-5

文献信息

• [EN] HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010120621A1

  公开（公告）日：2010-10-21

  This disclosure concerns novel compounds of Formula (I) or Formula (II) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

  本公开涉及规范中定义的Formula (I)或Formula (II)的新化合物以及包含这些新化合物的组合物。这些化合物是有用的抗病毒剂，特别是在抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能方面。因此，本公开还涉及通过使用这些新化合物或包含这些新化合物的组合物来治疗HCV相关疾病或症状的方法。
• METHOD FOR THE CONTROLLED HYDROFORMYLATION AND ISOMERIZATION OF A NITRILE/ESTER/OMEGA UNSATURATED FATTY ACID
  申请人：ARKEMA FRANCE

  公开号：US20160115120A1

  公开（公告）日：2016-04-28

  A method to synthesize a fatty nitrile/ester aldehyde comprising the following steps: 1) hydroformylation of a ω-unsaturated fatty nitrile/ester/acid substrate under particular conditions of partial pressure, temperature, reaction time, conversion rate of the ω-unsaturated fatty nitrile/ester/acid reactant, catalyst, [substrate]/[metal] molar ratio and [ligand]/[metal] molar ratio so as after the reaction to obtain: a hydroformylation product comprising at least one fatty nitrile/ester/acid aldehyde of formula: OHC—(CH 2 ) r+2 —R, and an isomerate comprising at least one fatty nitrile/ester/acid isomer with internal unsaturation in which at least 80% of the internal isomer(s) of the isomerate are formed of the ω-1 unsaturated isomer of formula CH 3 —CH═CH—(CH 2 ) r−1 —R; followed by: 2) separation and recovery of the fatty nitrile/ester/acid aldehyde and of the isomerate.

  一种合成脂肪酸腈/酯醛的方法，包括以下步骤： 1）在特定的分压、温度、反应时间、ω-不饱和脂肪酸腈/酯/酸底物的转化率、催化剂、[底物]/[金属]摩尔比和[配体]/[金属]摩尔比条件下，对ω-不饱和脂肪酸腈/酯/酸底物进行氢甲酰化反应，以便在反应后获得： a. 一个氢甲酰化产物，包括至少一种公式为 OHC—(CH2)r+2—R 的脂肪酸腈/酯/酸醛；和 b. 一个异构物，包括至少一种具有内部不饱和的脂肪酸腈/酯/酸异构体，其中至少80%的内部异构体是由公式为 CH3—CH═CH—(CH2)r−1—R 的ω-1不饱和异构体形成的；随后进行： 2）分离和回收脂肪酸腈/酯/酸醛和异构物。
• SELECTIVE HYDROGENATION OF ALDEHYDE WITH RU/BIDENTATE LIGANDS COMPLEXES
  申请人：FIRMENICH SA

  公开号：US20140243526A1

  公开（公告）日：2014-08-28

  The present invention relates to processes for the reduction by hydrogenation, using molecular H 2 , of a C 5 -C 20 substrate containing one or two aldehydes functional groups into the corresponding alcohol or diol, characterized in that said process is carried out in the presence of —at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the N 2 P 2 O 2 , wherein the coordinating atoms N 2 are provided by a first bidentate ligand, the coordinating atoms P 2 are provided by a second bidentate ligand and the coordinating atoms O 2 are provided by two non-linear carboxylate ligands; and —optionally of an acidic additive.

  本发明涉及利用分子H2对含有一个或两个醛基官能团的C5-C20底物进行加氢还原的过程，将其转化为相应的醇或二醇，其特征在于所述过程在以下条件下进行：—至少一种催化剂或前驱体存在，其形式为具有N2P2O2配位球的钌配合物，其中配位原子N2由第一双齿配体提供，配位原子P2由第二双齿配体提供，配位原子O2由两个非线性羧酸盐配体提供；和—可选地加入酸性添加剂。
• LIGANDS OF THE BENZO [H] QUINOLINE CLASS AND TRANSITION METAL COMPLEXES CONTAINING THEM AND USE OF SAID COMPLEXES AS CATALYSTS
  申请人：Rigo Pierluigi

  公开号：US20100152448A1

  公开（公告）日：2010-06-17

  A new class of ligands derived from benzo[h]quinoline are described and these ligands are used to prepare several novel transition metal complexes. The complexes are preferably of the group VIII transition metals iron, ruthenium or osmium, with the benzo[h]quinoline ligands acting as tridentate ligands. The complexes described are proved to be very active catalysts for the reduction of ketones and aldehydes to alcohols, via hydrogen transfer and hydrogenation reactions. These compounds hence can be usefully employed as catalysts in said reduction reactions.

  描述了一类源自苯并[h]喹啉的新型配体，并利用这些配体制备了几种新型过渡金属配合物。这些配合物优选为第VIII族过渡金属铁、钌或锇，其中苯并[h]喹啉配体作为三齿配体。所描述的配合物证明是非常有效的催化剂，用于通过氢转移和氢化反应将酮和醛还原为醇。因此，这些化合物可以有效地用作上述还原反应的催化剂。
• [EN] COMPLEXES OF RUTHENIUM WITH 2-(AMINOMETHYL)PYRIDINES AND PHOSPHINES, THEIR PREPARATION AND USE AS CATALYSTS<br/>[FR] COMPLEXES DE RUTHENIUM CONTENANT DES 2-(AMINOMETHYL)PYRIDINES ET DES PHOSPHINES, LEUR PREPARATION ET LEUR UTILISATION COMME CATALYSEURS
  申请人：UNIV DEGLI STUDI UDINE

  公开号：WO2005105819A1

  公开（公告）日：2005-11-10

  The patent describes a new class of ruthenium (II) complexes containing as ligands 2-(aminomethyl)pyridines and phosphines, proven to be extremely active catalysts in the reduction of ketones to alcohols via hydrogen transfer. By using 2-propanol as the hydrogen source with said ruthenium complexes, high yields of the corresponding alcohol can be rapidly obtained starting from linear and cyclic alkyl aryl, dialkyl and diaryl ketones. The conversion of ketones to alcohols can reach 100% if operating in a gaseous hydrogen atmosphere (2 - 3 atm). Where the phosphines used are optically active, starting from prochiral ketone compounds various types of optically active alcohols can be produced, being important intermediates in the pharmaceutical industry, in the agrochemical industry and for fine chemicals generally.

  该专利描述了一种新的钌(II)配合物类，其含有2-(氨甲基)吡啶和膦作为配体，已被证明是在氢转移还原酮为醇反应中极为活性的催化剂。通过使用2-丙醇作为氢源与该钌配合物，可以从线性和环烷基芳基、双烷基和双芳基酮中快速得到相应的醇高收率。如果在氢气气氛下(2-3大气压)操作，酮到醇的转化率可以达到100%。如果使用的膦是光学活性的，则可以从原始手性酮化合物中生产各种类型的光学活性醇，这些醇是制药工业、农化工业和精细化学品通常的重要中间体。