2-iodobenzyl formate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-iodobenzyl formate
• 英文别名: (2-Iodophenyl)methyl formate；(2-iodophenyl)methyl formate
• 化学式: C₈H₇IO₂
• 分子量: 262.047
• InChiKey: OPDKKJNXUQWMKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-碘苄醇 、 N,N-二甲基甲酰胺 在 硫酰氟 、 caesium carbonate 作用下， 反应 12.0h， 以88%的产率得到2-iodobenzyl formate
  参考文献：
  名称：

  SO 2 F 2介导的亲核酰胺羰基和亲电子醇羟基的合成。

  摘要：

  我们发现，随着硫酰氟的促进，酰胺的羰基作为亲核试剂发挥作用，而醇的羟基被活化以作为亲电试剂官能化。这项研究表明，在不使用过渡金属的情况下，酰胺CN键很容易被精密的亲核试剂裂解形成酯CO键。用44个实例证明了广泛的底物范围和出色的官能团相容性，产率高达99％。

  DOI：

  10.1021/acs.orglett.9b03274

文献信息

• [EN] NOVEL DENDRIMER COMPOUND, A BIOCHIP USING THE SAME AND A FABRICATING METHOD THEREOF<br/>[FR] NOUVEAU COMPOSE DENDRIMERE, BIOPUCE UTILISANT CE COMPOSE ET PROCEDE DE FABRICATION CORRESPONDANT
  申请人：POSTECH FOUNDATION

  公开号：WO2005016869A1

  公开（公告）日：2005-02-24

  The present invention relates to novel dendrimer compounds and method of producing a bio chip using the dendrimer. The present invention relates to the dendrimer that is represented by Chemical Formula 1, a substrate where the dendrimer is fixed, and the bio chip utilizing these compounds. [Chemical Formula I] wherein X is amine protecting group that is separated by acid, L is a spacer or -R-C(O)-NH- and R is substituted or unsubstituted hydrocarbon.

  本发明涉及新型树枝状聚合物化合物以及利用该树枝状聚合物制备生物芯片的方法。本发明涉及由化学式1表示的树枝状聚合物，其中X是由酸分离的胺保护基，L是间隔物或-R-C(O)-NH-，R是取代或未取代的碳氢化合物的底物，以及利用这些化合物的生物芯片。【化学式I】
• 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles
  申请人：Tsubouchi Hidetsugu

  公开号：US20060094767A1

  公开（公告）日：2006-05-04

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R 1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R 2 represents a group —OR 3 or the like, and R 3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R 1 and —(CH 2 ) n R 2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R 41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis , multi-drug-resistant Mycobacterium tuberculosis , and atypical acid-fast bacteria.

  本发明提供了一种2,3-二氢-6-硝基咪唑并[2,1-b]噁唑化合物，其通式如下：其中，R1代表氢原子或C1-C6烷基，n代表0到6的整数，R2代表—OR3或类似的基团，R3代表氢原子、C1-C6烷基或类似的基团，或者R1和—(CH2)nR2可以通过相邻的碳原子通过氮原子结合在一起形成一个螺环，其通式为（H）：其中，R41为氢、C1-C6烷基或类似的基团。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型酸性快速细菌具有优异的杀菌作用。
• DENDRIMERIC COMPOUNDS COMPRISING AMINO ACIDS, HYPERBRANCHED CORE COMPOUND, PROCESS FOR PREPARATION OF DENDRIMERIC COMPOUNDS COMPRISING AMINO ACIDS AND HYPERBRANCHED CORE COMPOUND, AND USE THEREOF
  申请人：Lipkowska Zofia

  公开号：US20110152175A1

  公开（公告）日：2011-06-23

  The invention provides dendrimeric compounds of the formula 1 comprising amino acids, wherein n is an integer of 1-4, T is an alkylidene —(CH2)2CONH(CH2)2- group, R2 is an —NH2 group or a moiety of a primary organic amine, and P is an amino acid and/or peptide moiety, wherein at least one hydrogen atom of at least one amino group is optionally replaced by a protective group, and a hyperbranched core compound of the formula 3, wherein T and R2 are as defined above. The invention provides also a process for the preparation of a dendrimeric compound and a hyperbranched core, wherein the process employs addition reactions of alkyl acrylate and a basic amino acid, and use of a hyperbranched core for the preparation of a dendrimeric compound comprising amino acids. The invention provides also use of dendrimeric compounds for the preparation of the medicament for inhibiting growth of bacterial cells, fungi and tumor cells.

  本发明提供了公式1的树状化合物，其中包括氨基酸，其中n为1-4的整数，T为烷基亚甲基—(CH2)2CONH(CH2)2-基团，R2为—NH2基团或初级有机胺的基团，P为氨基酸和/或肽的基团，其中至少一个氨基团的至少一个氢原子可选择性地被保护基替代，以及公式3的高分支核心化合物，其中T和R2如上所定义。本发明还提供了制备树状化合物和高分支核心的方法，其中该方法采用烷基丙烯酸酯和碱性氨基酸的加成反应，并使用高分支核心制备包含氨基酸的树状化合物。本发明还提供了使用树状化合物制备抑制细菌细胞、真菌和肿瘤细胞生长的药物的用途。
• COMPOUNDS AND THERAPEUTIC USES THEREOF
  申请人：KUMAR Dange Vijay

  公开号：US20100240630A1

  公开（公告）日：2010-09-23

  The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.

  该发明涉及用于治疗病毒感染的化合物、药物组合物和方法。
• 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1555267A1

  公开（公告）日：2005-07-20

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R2 represents a group -OR3 or the like, and R3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R1 and -(CH2)nR2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and a typical acid-fast bacteria.

  本发明提供了由以下通式代表的 2，3-二氢-6-硝基咪唑并[2，1-b]恶唑化合物： 其中R1代表氢原子或C1-C6烷基，n代表0至6的整数，R2代表基团-OR3或类似基团，R3代表氢原子、C1-C6烷基或类似基团，或者R1和-(CH2)nR2可以通过氮原子与相邻的碳原子相互结合，从而形成通式(H)代表的螺环： 其中 R41 为氢、C1-C6 烷基或类似基团。本化合物对结核分枝杆菌、多重耐药结核分枝杆菌和典型的耐酸细菌有很好的杀菌作用。