5-溴-2,5-二甲基-己-2-烯 | 120089-30-7

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 中文名称: 5-溴-2,5-二甲基-己-2-烯
• 英文名称: 5-bromo-2,5-dimethyl-hex-2-ene
• 英文别名: 2-bromo-2,5-dimethyl-4-hexene；2-Brom-2.5-dimethyl-hexen-(4)；5-Bromo-2,5-dimethylhex-2-ene
• CAS: 120089-30-7
• 化学式: C₈H₁₅Br
• 分子量: 191.111
• InChiKey: YLTBMRGKHJRGRW-UHFFFAOYSA-N

物化性质

• 沸点：
  56-60 °C(Press: 13 Torr)
• 密度：
  1.142±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  5-溴-2,5-二甲基-己-2-烯 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 12.0h， 生成 2,5-二溴-2,5-二甲基己烷
  参考文献：
  名称：

  Julia,M. et al., Bulletin de la Societe Chimique de France, 1960, p. 1735 - 1739

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-Dimethyl-2-<α-hydroxy-isopropyl>-cyclopropan 在 氢溴酸 作用下， 生成 5-溴-2,5-二甲基-己-2-烯
  参考文献：
  名称：

  Julia,M. et al., Bulletin de la Societe Chimique de France, 1960, p. 1735 - 1739

  摘要：

  DOI：

文献信息

• Asymmetric copper complex and cyclopropanation reaction using the same
  申请人：——

  公开号：US20020177718A1

  公开（公告）日：2002-11-28

  There are disclosed asymmetric copper complex comprising, as components, (a) an optically active bisoxazoline compound of formula (1): 1 wherein R 1 and R 2 are different and each represent a hydrogen atom, an alkyl group, a cycloalkyl group, or a phenyl or aralkyl group which may be substituted, R 3 and R 4 each represent a hydrogen atom, an alkyl group, a cycloalkyl group, or a phenyl or aralkyl group which may be substituted, or R 3 and R 4 may be bonded to each other to form a C 3-5 cyclic alkylene group, R 5 represents a hydrogen atom or a C 1-6 alkyl group, or the two R 5 groups may be bonded to each other to represent a C 3-5 cyclic alkylene group, (b) a monovalent or divalent copper compound, and (c) a strong acid or a Lewis acid or a mixture thereof, and a process for producing an optically active cyclopropanecarboxylate using the same.

  揭示了包括以下组分的不对称铜络合物：（a）公式（1）的手性双噁唑啉化合物：其中R1和R2不同，每个代表氢原子、烷基、环烷基、苯基或芳基烷基，可能被取代，R3和R4每个代表氢原子、烷基、环烷基、苯基或芳基烷基，可能被取代，或者R3和R4可以相互连接形成C3-5环烷基，R5代表氢原子或C1-6烷基，或者两个R5基团可以相互连接形成C3-5环烷基；（b）一价或二价铜化合物；和（c）强酸或Lewis酸或二者混合物，以及使用它们制备手性环丙烷羧酸酯的方法。
• Optically active bisoxazoline compounds, process for production of the same and use thereof
  申请人：Itagaki Makoto

  公开号：US20060149077A1

  公开（公告）日：2006-07-06

  Optically active bisoxazoline compounds represented by the general formula (1), a process for producing the compounds, and a process for producing cyclopropanecarboxylic esters by using the same: wherein R 1 and R 2 are the same and each represents C 1-6 alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted phenyl or R 1 and R 2 are bonded each other together with the carbon atom of oxazoline ring to which they are bonded to form a ring; R 3 is substituted or unsubstituted naphthyl; R 4 and R 5 are the same and each represent hydrogen or C 1-6 alkyl, or R 4 and R 5 are bonded each other together with the carbon atom to which they are bonded to form a cycloalkyl ring having 3 to 6 carbon atoms; and * represents an asymmetric center.

  光学活性的双噁唑啉化合物由通式（1）表示，制备该化合物的方法以及使用该化合物制备环丙烷羧酸酯的方法： 其中，R1和R2相同，分别表示C1-6烷基，取代或未取代的芳基烷基或取代或未取代的苯基，或者R1和R2相互结合形成环，与它们所连接的噁唑环的碳原子相连；R3是取代或未取代的萘基；R4和R5相同，分别表示氢或C1-6烷基，或者R4和R5相互结合形成有3至6个碳原子的环状烷基环；*表示一个不对称中心。
• Process for producing optically active cyclopropanecarboxylic acid esters
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0891965A1

  公开（公告）日：1999-01-20

  A process for producing an optically active cyclopropanecarboxylic acid ester which is characterized by reacting a prochiral olefin with a diazoacetic acid ester in the presence of a copper complex obtained by reacting an optically active bisoxazoline ligand with a copper compound.

  一种生产光学活性环丙烷羧酸酯的工艺，其特征是在光学活性双噁唑啉配体与铜化合物反应得到的铜络合物存在下，使亲手性烯烃与重氮乙酸酯反应。
• Copper complexes of optically active bisoxazolines as enantioselective catalysts in cyclopropanation reactions
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0895992A2

  公开（公告）日：1999-02-10

  An optically active bisoxazoline compound of the formula [I]: wherein R1 represents an alkyl group, cycloalkyl group, aralkyl group, phenyl group which may be substituted or an alkoxy group and two geminal alkyl groups may be joined together to form a cyclic structure;    R2 represents an alkyl group , cycloalkyl group, aralkyl group or phenyl group which may be substituted;    R3 represents a hydrogen atom, (C2-C4)alkyl group or cycloalkyl group; and    the asterisk * represents an asymmetric carbon atom.

  式[I]的光学活性双噁唑啉化合物： 其中 R1 代表烷基、环烷基、芳基、可被取代的苯基或烷氧基，两个烷基可连接在一起形成环状结构； R2 代表烷基、环烷基、芳基或可被取代的苯基； R3 代表氢原子、(C2-C4)烷基或环烷基；以及 星号 * 代表不对称碳原子。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANE COMPOUND AND ASYMMETRIC COPPER COMPLEX FOR USE IN THE SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1674445A1

  公开（公告）日：2006-06-28

  A process for producing an optically active cyclopropane compound represented by the formula (4): wherein R3, R4, R5 and R6 are the same or different, and represent a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, and so on; and R7 represents a C1-6 alkyl group; and * represents an asymmetric carbon atom, which comprises reacting a prochiral olefin represented by the formula (2): wherein R3, R4, R5, and R6 are as described above, with a diazoacetic acid ester represented by the formula (3):         N2CHCO2R7     (3) wherein R7 is as defined above, in the presence of an asymmetric copper complex prepared from an optically active cycloalkylidenebisoxazoline compound represented by the formula (1): wherein R1 represents a hydrogen atom, a C1-6 alkyl group, and so on; R2 represents a C1-6 alkyl group and so on; and n represents an integer of 0 to 3; provided that, two R1s may be bonded each other together with the carbon atom to which they are bonded to form a ring; and * represents an asymmetric carbon atom, and a copper compound, is provided.

  一种生产由式（4）表示的光学活性环丙烷化合物的工艺： 其中 R3、R4、R5 和 R6 相同或不同，代表氢原子、卤素原子、取代或未取代的烷基等；R7 代表 C1-6 烷基；* 代表不对称碳原子、 其中包括使式 (2) 所代表的手性烯烃发生反应： 其中 R3、R4、R5 和 R6 如上所述，与式 (3) 所代表的重氮乙酸酯反应： N2CHCO2R7 (3) 其中 R7 如上定义，在由式（1）代表的光学活性环烷基亚双噁唑啉化合物制备的不对称铜络合物存在下： 其中，R1 代表氢原子、C1-6 烷基等；R2 代表 C1-6 烷基等；n 代表 0 至 3 的整数；条件是两个 R1 可与它们所键合的碳原子一起相互键合以形成环；* 代表不对称碳原子、 以及一种铜化合物。