(Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide | 1352346-67-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide
• 英文别名: 2-oxo-2-[2-(2-oxoindol-3-yl)hydrazinyl]-N-phenylacetamide
• CAS: 1352346-67-8；301819-49-8
• 化学式: C₁₆H₁₂N₄O₃
• 分子量: 308.296
• InChiKey: WVUJDTMIYSOBHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.66
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide 、 cobalt(II) acetate 以 乙醇 为溶剂， 以85%的产率得到[Co(((Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide)(-2H))(water)3]
  参考文献：
  名称：

  Synthesis, spectroscopic characterization and thermal behavior of metal complexes formed with (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide (H2OI)

  摘要：

  Complexes of Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and U(IV)O-2 with (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide (H2OI) are reported and have been characterized by various spectroscopic techniques like (IR, UV-Vis, ESR H-1 and C-13 NMR) as well as magnetic and thermal (TG and DTA) measurements. It is found that the ligand behaves as a neutral tridentate, neutral tetradentate, monoanionic tridentate, monoanionic tridentate and dianionic tridentate. An octahedral geometry for all complexes except [Cu-2(H2OI)(OAc)(4)](H2O)(2) and [Cu(HOI)Cl](H2O)(2) which have a square planar geometry. Furthermore, kinetic parameters were determined for each thermal degradation stage of some studied complexes using Coats-Redfern and Horowitz-Metzger methods. The bond lengths, bond angles, HOMO, LUMO and dipole moments have been calculated to confirm the geometry of the ligand and the investigated complexes. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2011.10.036
• 作为产物：
  描述：

  草酸乙酯 在 肼 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide
  参考文献：
  名称：

  Synthesis, spectroscopic characterization and thermal behavior of metal complexes formed with (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide (H2OI)

  摘要：

  Complexes of Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and U(IV)O-2 with (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide (H2OI) are reported and have been characterized by various spectroscopic techniques like (IR, UV-Vis, ESR H-1 and C-13 NMR) as well as magnetic and thermal (TG and DTA) measurements. It is found that the ligand behaves as a neutral tridentate, neutral tetradentate, monoanionic tridentate, monoanionic tridentate and dianionic tridentate. An octahedral geometry for all complexes except [Cu-2(H2OI)(OAc)(4)](H2O)(2) and [Cu(HOI)Cl](H2O)(2) which have a square planar geometry. Furthermore, kinetic parameters were determined for each thermal degradation stage of some studied complexes using Coats-Redfern and Horowitz-Metzger methods. The bond lengths, bond angles, HOMO, LUMO and dipole moments have been calculated to confirm the geometry of the ligand and the investigated complexes. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2011.10.036

文献信息

• Selective Molecular Sequestration with Concurrent Natural Product Functionalization and Derivatization: From Crude Natural Product Extracts to a Single Natural Product Derivative in One Step
  作者：Viktor Krchňák、Jaroslav Zajíček、Patricia A. Miller、Marvin J. Miller

  DOI：10.1021/jo201361s

  日期：2011.12.16

  resin-bound nitroso compound sequestered a single unexpected component from crude plant seed extracts. Several plants, including Piper nigrum, Eugenia caryophyllata, and Pimenta dioica, were extracted with organic solvent in the presence of a nitroso-containing resin. The nitroso resin selectively sequestered a single compound, β-caryophyllene, via a chemo- and regioselective ene reaction. The ene product

  树脂结合的亚硝基化合物从粗植物种子提取物中隔离了一种意想不到的成分。在含亚硝基树脂的存在下，用有机溶剂提取了黑胡椒、石竹和小白椒等几种植物。亚硝基树脂通过化学和区域选择性烯反应选择性地隔离单一化合物 β-石竹烯。The ene product was released from the resin, and proper selection of the solid-phase linker and cleavage cocktail allowed concomitant further transformation of the primary ene product to a novel functionalized polycycle. 初步研究表明，新的含羟胺的天然产物衍生物具有抗菌活性。
• Synthesis, spectroscopic characterization and thermal behavior of metal complexes formed with (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide (H2OI)
  作者：T.A. Yousef、T.H. Rakha、Usama El Ayaan、G.M. Abu El Reash

  DOI：10.1016/j.molstruc.2011.10.036

  日期：2012.1

  Complexes of Co(II), Ni(II), Cu(II), Cd(II), Zn(II) and U(IV)O-2 with (Z)-2-oxo-2-(2-(2-oxoindolin-3-ylidene)hydrazinyl)-N-phenylacetamide (H2OI) are reported and have been characterized by various spectroscopic techniques like (IR, UV-Vis, ESR H-1 and C-13 NMR) as well as magnetic and thermal (TG and DTA) measurements. It is found that the ligand behaves as a neutral tridentate, neutral tetradentate, monoanionic tridentate, monoanionic tridentate and dianionic tridentate. An octahedral geometry for all complexes except [Cu-2(H2OI)(OAc)(4)](H2O)(2) and [Cu(HOI)Cl](H2O)(2) which have a square planar geometry. Furthermore, kinetic parameters were determined for each thermal degradation stage of some studied complexes using Coats-Redfern and Horowitz-Metzger methods. The bond lengths, bond angles, HOMO, LUMO and dipole moments have been calculated to confirm the geometry of the ligand and the investigated complexes. (C) 2011 Elsevier B.V. All rights reserved.