7-methoxy-2,2-diphenyl-benzo[1,3]dioxole-5-carboxylic acid | 717131-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-methoxy-2,2-diphenyl-benzo[1,3]dioxole-5-carboxylic acid
• 英文别名: 7-Methoxy-2,2-diphenyl-benzo[1,3]dioxol-5-carbonsaeure；3-Methoxy-4.5-diphenylmethylendioxy-benzoesaeure；7-Methoxy-2,2-diphenyl-1,3-benzodioxole-5-carboxylic acid
• CAS: 717131-59-4
• 化学式: C₂₁H₁₆O₅
• 分子量: 348.355
• InChiKey: GPIAHEOCAUKJPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  7-methoxy-2,2-diphenyl-benzo[1,3]dioxole-5-carboxylic acid 在 四氯化碳 、 五氯化磷 作用下， 生成 7-methoxy-2,2-diphenyl-benzo[1,3]dioxole-5-carbonyl chloride
  参考文献：
  名称：

  Bradley; Robinson; Schwarzenbach, Journal of the Chemical Society, 1930, p. 796,811

  摘要：

  DOI：
• 作为产物：
  描述：

  二氯二苯甲烷 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 7-methoxy-2,2-diphenyl-benzo[1,3]dioxole-5-carboxylic acid
  参考文献：
  名称：

  Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity

  摘要：

  A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-l-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.005

文献信息

• METHOD FOR THE SYNTHESIS OF ANTHOCYANINS
  申请人：Bakstad Einar

  公开号：US20090111975A1

  公开（公告）日：2009-04-30

  The present invention relates to methods of preparing anthocyanins, and methods of preparing precursors of anthocyanins. The methods utilise a coupling reaction between a sugar and a suitable electrophilic precursor to form Eastern half intermediates that are then reacted with Western half intermediates to form the target anthocyanins. Some Eastern half intermediates and electrophilic precursors also form part of the invention.

  本发明涉及制备花青素的方法，以及制备花青素前体的方法。该方法利用糖与适当的亲电前体之间的偶联反应形成东半部分中间体，然后将其与西半部分中间体反应以形成目标花青素。一些东半部分中间体和亲电前体也是本发明的一部分。
• SALTS OF PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1091958A1

  公开（公告）日：2001-04-18
• US8513395B2
  申请人：——

  公开号：US8513395B2

  公开（公告）日：2013-08-20
• [EN] SALTS OF PAROXETINE<br/>[FR] SELS DE PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000001692A1

  公开（公告）日：2000-01-13

  Piperidine compounds, processes for preparing them, pharmaceutical compositions comprising them and their use in therapy are disclosed.
• Bradley; Robinson; Schwarzenbach, Journal of the Chemical Society, 1930, p. 796,811
  作者：Bradley、Robinson、Schwarzenbach

  DOI：——

  日期：——