N-tetradecyl-2-propynamide | 146722-52-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tetradecyl-2-propynamide
• 英文别名: N-tetradecylprop-2-ynamide
• CAS: 146722-52-3
• 化学式: C₁₇H₃₁NO
• 分子量: 265.439
• InChiKey: KTYPMRNZNCOGTD-UHFFFAOYSA-N

物化性质

• 熔点：
  55-56 °C(Solv: hexane (110-54-3))
• 密度：
  0.888±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-tetradecyl-2-propynamide 在 copper(l) iodide 、 α-1,3-fucosyltransferase 、 N,N-二异丙基乙胺 作用下， 以 甲醇 为溶剂， 反应 9.0h， 生成 sialyl Lewis x
  参考文献：
  名称：

  Synthesis of Sugar Arrays in Microtiter Plate

  摘要：

  1,3-Dipolar cycloadditions between azides and alkynes were exploited to attach oligosaccharides to a C-14 hydrocarbon chain that noncovalently binds to the microtiter well surface. Synthesis of sugar arrays was performed on a micromolar scale in situ in the microtiter plate. As a model study, the beta-galactosyllipid 5 was displayed on a 4-mumol scale. Formation of product was confirmed via ESI-MS, and the yield was determined via chemical and biological assays. Several complex carbohydrates (6-16) were also displayed in microtiter plates and successfully screened with various lectins. Moreover, sialyl Lewis x (17) was synthesized via the enzymatic fucosylation of a precursor displayed in the plate. Studies on inhibition of this biotransformation have been carried out, and the IC50 value found for the known inhibitor 20 was consistent with previous studies in solution.

  DOI：

  10.1021/ja020887u
• 作为产物：
  描述：

  十四胺 、 丙炔酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以65%的产率得到N-tetradecyl-2-propynamide
  参考文献：
  名称：

  Synthesis of Sugar Arrays in Microtiter Plate

  摘要：

  1,3-Dipolar cycloadditions between azides and alkynes were exploited to attach oligosaccharides to a C-14 hydrocarbon chain that noncovalently binds to the microtiter well surface. Synthesis of sugar arrays was performed on a micromolar scale in situ in the microtiter plate. As a model study, the beta-galactosyllipid 5 was displayed on a 4-mumol scale. Formation of product was confirmed via ESI-MS, and the yield was determined via chemical and biological assays. Several complex carbohydrates (6-16) were also displayed in microtiter plates and successfully screened with various lectins. Moreover, sialyl Lewis x (17) was synthesized via the enzymatic fucosylation of a precursor displayed in the plate. Studies on inhibition of this biotransformation have been carried out, and the IC50 value found for the known inhibitor 20 was consistent with previous studies in solution.

  DOI：

  10.1021/ja020887u

文献信息

• Halopropiolamide compound, production and use thereof
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0649835A1

  公开（公告）日：1995-04-26

  There are provided with a novel N-substituted-3-halopropiolamide compound, a method of producing the compound, and a composition for controlling noxious organisms containing the compound. The present compound exhibits superior antimicrobial and antifungal effects. Pest control agents containing the compound can advantageously be used for wide applications.

  本文提供了一种新型 N-取代-3-卤代丙炔酰胺化合物、一种生产该化合物的方法以及一种含有该化合物的控制有害生物的组合物。本化合物具有优异的抗微生物和抗真菌效果。含有该化合物的害虫控制剂可被广泛应用。
• N-substituted-3-iodopropiolamide, production and use thereof
  申请人：TAKEDA CHEMICAL INDUSTRIES, LTD.

  公开号：EP0519427B1

  公开（公告）日：1995-04-26
• US5538998A
  申请人：——

  公开号：US5538998A

  公开（公告）日：1996-07-23