(Rs)-N-((S)-1-(2-ethynylphenyl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide | 1560811-55-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Rs)-N-((S)-1-(2-ethynylphenyl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide
• CAS: 1560811-55-3
• 化学式: C₁₆H₂₁NOS
• 分子量: 275.415
• InChiKey: QTFCEDYMSQYKRF-HNAYVOBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.34
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.1
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  3,3-二甲基-1-(三氟甲基)-1,2-苯并碘氧杂戊环 、 (Rs)-N-((S)-1-(2-ethynylphenyl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide 在 copper(l) iodide 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以30%的产率得到(Rs)-2-methyl-N-((S)-1-(2-(3,3,3-trifluoroprop-1-yn-1-yl)phenyl)but-3-en-1-yl)propane-2-sulfinamide
  参考文献：
  名称：

  Asymmetric Allylation/Pauson–Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues

  摘要：

  Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson-Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.

  DOI：

  10.1021/ol500142c
• 作为产物：
  描述：

  (Rs)-2-methyl-N-((S)-1-(2-((trimethylsilyl)ethynyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide 在 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以61%的产率得到(Rs)-N-((S)-1-(2-ethynylphenyl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  Asymmetric Allylation/Pauson–Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues

  摘要：

  Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson-Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.

  DOI：

  10.1021/ol500142c