4'-[(2R)-2-丁炔基]-4-联苯甲醛 | 73003-65-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4'-[(2R)-2-丁炔基]-4-联苯甲醛
• 英文名称: 4-sec-butylbenzophenone
• 英文别名: 4-sec-butyl-benzophenone；4-sec-Butyl-benzophenon；Methanone, [4-(1-methylpropyl)phenyl]phenyl-；(4-butan-2-ylphenyl)-phenylmethanone
• CAS: 73003-65-3
• 化学式: C₁₇H₁₈O
• mdl: MFCD11544992
• 分子量: 238.329
• InChiKey: UOOYYNLYCWHQKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.235
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4'-[(2R)-2-丁炔基]-4-联苯甲醛 、 硝酸 生成 4-苯甲酰苯甲酸
  参考文献：
  名称：

  Friedel—Crafts Acylations of Some Sterically Hindered Alkylbenzenes

  摘要：

  DOI：

  10.1021/ja01262a055
• 作为产物：
  描述：

  仲丁基苯 、 苯甲酸酐 在 三氯化铝 作用下， 反应 1.0h， 以3%的产率得到4'-[(2R)-2-丁炔基]-4-联苯甲醛
  参考文献：
  名称：

  固体超强酸催化烷基苯与苯甲酸酐的 Friedel-Crafts 苯甲酰化反应

  摘要：

  在固体超强酸 SO 4 /ZrO 2 、WO 3 /ZrO 2 上，在 100-110 °C 下用苯甲酸酐进行单烷基苯与甲基、乙基、丙基和丁基和二甲苯的液固相苯甲酰化反应，和 SO 4 / HfO 2 。通过WO 3 /ZrO 2 竞争法获得的反应活性比，甲苯对对二甲苯为1:4.6，邻二甲苯、间二甲苯和对二甲苯分别为1.1:10:1。尽管 SO 4 /ZrO 2 催化剂对甲苯和乙苯以 3:7 的邻位和对位异构体分布分别提供了 92% 和 97% 的高产率，但在催化剂上观察到丙基和丁基苯的产率低：即、丙苯和异丙苯分别为 5% 和 2%，异丁苯为 14%，丁苯、仲丁苯和叔丁苯的产率分别为 14%。在现有的烷基苯中检查了使用 AlCl 3 的通常的 Friedel-Crafts 苯甲酰化，以确认丙基和丁基苯的低反应性。结果与SO 4 /ZrO 2 催化剂相似；即，甲苯、乙苯、丙苯、异丙苯、丁苯、仲丁苯和叔丁苯在

  DOI：

  10.1246/bcsj.77.1893

文献信息

• Ruphos-mediated Suzuki cross-coupling of secondary alkyl trifluoroborates
  作者：Adri van den Hoogenband、Jos H.M. Lange、Jan Willem Terpstra、Melle Koch、Gerben M. Visser、Martin Visser、Ties J. Korstanje、Johann T.B.H. Jastrzebski

  DOI：10.1016/j.tetlet.2008.04.129

  日期：2008.6

  A Ruphos-mediated Suzuki cross-coupling between (hetero)aryl bromides and secondary alkyltrifluoroborates is described using palladium catalysis. The Ruphos ligand showed superior properties as compared to S-Phos in this type of reaction. This method constitutes a valuable extension to current methods for the straightforward production of secondary-alkylated (hetero)aryl derivatives.

  使用钯催化描述了Ruphos介导的（杂）芳基溴化物和仲烷基三氟硼酸盐之间的Suzuki交叉偶联。在这种类型的反应中，Ruphos配体与S-Phos相比显示出优异的性能。该方法构成了直接生产仲烷基化的（杂）芳基衍生物的现有方法的重要扩展。
• FATTY ACID COX INHIBITOR DERIVATIVES AND THEIR USES
  申请人：Milne Jill C.

  公开号：US20130065934A1

  公开（公告）日：2013-03-14

  The invention relates to fatty acid COX inhibitor derivatives; compositions comprising an effective amount of a fatty acid COX inhibitor derivative; and methods for treating or preventing a metabolic, autoimmune, inflammatory, or neurodegenerative disorder comprising the administration of an effective amount of a fatty acid COX inhibitor derivative.

  本发明涉及脂肪酸COX抑制剂衍生物；包含有效量脂肪酸COX抑制剂衍生物的组合物；以及治疗或预防代谢性、自身免疫性、炎症性或神经退行性疾病的方法，其中包括给予有效量的脂肪酸COX抑制剂衍生物。
• HYBRID PHOTOINITIATORS
  申请人：NESVADBA PETER

  公开号：US20160168279A1

  公开（公告）日：2016-06-16

  Compounds of the formula I wherein m is 1 or 2; R 1 , R 2 , R 4 and R 5 independently of one another are hydrogen, C 1 -C 4 alkyl, C 5 -C 7 cycloalkyl, phenyl, C 1 -C 4 alkoxy, C 5 -C 7 cycloalkoxy or phenoxy; R 3 , if m is 1, has one of the meanings as given above for R 1 , R 2 , R 4 and R 5 ; R 3 , if m is 2, is a divalent group; R 6 is hydrogen or C 1 -C 4 alkyl; R 7 is hydrogen, and if R 6 is hydrogen then R 7 may additionally be C 1 -C 4 alkyl; R 8 is group A or B X is O, O—CH 2 — or —O(CHR 14 )—; n is 0-10; provided that (i) if n is 0, and X is O, then R 8 is a group A; (ii) if n is other than 0, then X is O and R 8 is the group A; R 9 and R 10 independently of one another are hydrogen or C 1 -C 4 alkyl; R 11 and R 12 independently of one another are C 1 -C 4 alkyl or form together with the C atom to which they are attached a 5 to 7 membered saturated carbocyclic ring; R 13 is hydrogen, C 1 -C 4 alkyl, C 5 -C 7 cycloalkyl, 2-tetrahydropyranyl or Si(C 1 -C 4 alkyl) 3 ; R 14 is a group A′ and R′ 13 has one of the meanings as given for R 13 or is the group C are effective photoinitiator compounds.

  化合物的公式为I，其中m为1或2；R1、R2、R4和R5彼此独立地为氢、C1-C4烷基、C5-C7环烷基、苯基、C1-C4烷氧基、C5-C7环烷氧基或苯氧基；如果m为1，R3具有上述R1、R2、R4和R5中的一个意义，如果m为2，则R3是一个二价基团；R6为氢或C1-C4烷基；R7为氢，如果R6为氢，则R7还可以是C1-C4烷基；R8为A基团或BX，其中X为O、O—CH2—或—O(CHR14)—；n为0-10；前提是：（i）如果n为0且X为O，则R8为A基团；（ii）如果n不为0，则X为O且R8为A基团；R9和R10彼此独立地为氢或C1-C4烷基；R11和R12彼此独立地为C1-C4烷基，或者与它们所连接的碳原子形成一个5到7个成员的饱和碳环；R13为氢、C1-C4烷基、C5-C7环烷基、2-四氢吡喃基或Si(C1-C4烷基)3；R14为A′基团，R′13具有上述R13的一个意义，或者是C基团，是有效的光引发剂化合物。
• A Comparative Product Investigation between Grignard Reactions of Benzophenone and Coupling Reactions of Electrogenerated Benzophenone Radical Anions and Alkyl Radicals in THF.
  作者：Torben Lund、Ditte Ohlrich、Pernille Borling、Adalgisa R. Andrade、Steen U. Pedersen、Hiroaki Murase、Tatsuya Shono、H. Toftlund

  DOI：10.3891/acta.chem.scand.53-0932

  日期：——

  The 1,6- to 1,2-addition product ratios of the Grignard reactions of benzophenone with t-, s- and n-C4H9MgCl have been compared with the corresponding ratios obtained by the electrolysis of benzophenone in presence of t-, s- and n- C4H9S+(CH3)(2), ClO4- in THF. The Grignard reaction ratios 0.81, 0.50 and 0.19, respectively, were obtained whereas the corresponding electrolysis ratios were 2.26, 1.23 and 1.61. From this comparison of product ratios ii. is concluded that none of the Grignard reactions of benzophenone proceeds through a complete free coupling process of benzophenone radical anions and butyl radicals. The ET character of the Grignard reactions of benzophenone with t-, s- and n- C4H9MgCl was estimated to be 65, 61 and 26%, respectively.
• THE EFFECT OF HALOGEN ATOMS AND OF ALKYL GROUPS ON THE RATES OF DISSOCIATION OF PENTAARYLETHANES
  作者：W. E. BACHMANN、E. CARLSON、J. C. MORAN

  DOI：10.1021/jo01164a023

  日期：1948.11