Oxidation of oxazolines derived from phenolic ω-arylalkanoic acids such as tyrosine with iodobenzene diacetate leads to spirocyclic amides in moderate yields. This reaction was heretofore unknown due to the propensity of free amide analogs of the oxazolines to furnish lactones upon oxidation.
用
碘代苯二
乙酸酯氧化衍生自
酚ω-芳基链烷酸(如
酪氨酸)的
恶唑啉,可得到中等收率的螺环酰胺。由于
恶唑啉的游离酰胺类似物倾向于在氧化时提供内酯,因此该反应迄今是未知的。