2-methoxymethyl-3-methyl-butyric acid | 89794-85-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methoxymethyl-3-methyl-butyric acid
• 英文别名: 2-Methoxymethyl-3-methyl-buttersaeure；2-Isopropyl-3-methoxy-propionsaeure；α-(Methoxymethyl)-isovaleriansaeure；3-Methoxy-2-isopropyl-propionsaeure；2-(Methoxymethyl)-3-methylbutanoic acid
• CAS: 89794-85-4
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: ZSZYDCNCFGNNGW-UHFFFAOYSA-N

物化性质

• 熔点：
  37-38 °C
• 沸点：
  128 °C(Press: 12 Torr)
• 密度：
  1.002±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxymethyl-3-methyl-butyric acid 在 乙醚 、 五氯化磷 、 氨 作用下， 生成 2-methoxymethyl-3-methyl-butyric acid amide
  参考文献：
  名称：

  Gol'mow; Afanas'ew, Zhurnal Obshchei Khimii, 1952, vol. 22, p. 1953,1956; engl. Ausg. S. 2001, 2004

  摘要：

  DOI：
• 作为产物：
  描述：

  Methoxymethyl-isopropyl-malonsaeure 生成 2-methoxymethyl-3-methyl-butyric acid
  参考文献：
  名称：

  Simonsen, Journal of the Chemical Society, 1908, vol. 93, p. 1784

  摘要：

  DOI：

文献信息

• HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：US20170240512A1

  公开（公告）日：2017-08-24

  The present invention relates to a compound represented by Formula (I): wherein -L- is —C(═X)—, or the like, —Z— is —NR 5 —, or the like, —Z A — is —NR 5A —, or the like, —W— is —C(R 8 R 9 )n-, —W A — is —C(R 3 R 4 )m-, B is substituted or unsubstituted aromatic carbocyclyl, or the like, Y is a bond, or the like, the ring C is a substituted or unsubstituted aromatic heterocycle, or the like, R 2 is a hydrogen atom, or the like, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

  本发明涉及一种由式（I）表示的化合物：其中-L-为—C(═X)—，或类似的，—Z—为—NR5—，或类似的，—ZA—为—NR5A—，或类似的，—W—为—C(R8R9)n-，—WA—为—C(R3R4)m-，B为取代或未取代的芳香环烃基，或类似的，Y为键，或类似的，环C为取代或未取代的芳香杂环，或类似的，R2为氢原子，或类似的，或其药学上可接受的盐，或包括其的药物组成。
• CEPHEM COMPOUND HAVING PSEUDO-CATECHOL GROUP
  申请人：Yamawaki Kenji

  公开号：US20130079319A1

  公开（公告）日：2013-03-28

  A compound of the formula: wherein X is —N═, —CH═, or the like; W is —CH 2 — or the like; U is —S— or the like; R 1 and R 2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; Q is a single bond or the like; R 3 is hydrogen or the like; Ring A is a 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms; each R 4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; G is —C(═O)— or the like; D is a single bond, —NH—, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.

  该化合物的化学式为：其中X为—N═、—CH═或类似基团；W为—CH2—或类似基团；U为—S—或类似基团；R1和R2各自独立地为氢、卤素、选择性取代的低碳基或类似基团；Q为单键或类似键；R3为氢或类似基团；环A为一个6元芳香杂环基团，具有1-3个氮原子；每个R4独立地为氢、卤素或类似基团；m为0到2的整数；G为—C(═O)—或类似基团；D为单键、—NH—或类似基团；E为一个环状季铵基团，或者是在7侧链上的氨基处的酯、保护化合物、药学上可接受的盐或其溶剂化物。
• PYRROLIDINYL UREA, PYRROLIDINYL THIOUREA AND PYRROLIDINYL GUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
  申请人：Allen Shelley

  公开号：US20150166564A1

  公开（公告）日：2015-06-18

  Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R 1 , R 2 , R a , R b , R c , R d , X, Y, B, and Ring C are as defined herein, and wherein the Y—B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

  化合物I的公式：或其立体异构体、互变异构体、药学上可接受的盐、溶剂或前药，其中R1、R2、Ra、Rb、Rc、Rd、X、Y、B和环C的定义如本文所述，其中Y-B基团和NH-C（═X）-NH基团处于反式构象，是TrkA激酶的抑制剂，可用于治疗可以通过TrkA激酶抑制剂治疗的疾病，例如疼痛、癌症、炎症、神经退行性疾病和某些传染病。
• IMIDAZOLE COMPOUND, METAL SURFACE TREATMENT LIQUID, METAL SURFACE TREATMENT METHOD, AND LAMINATE PRODUCTION METHOD
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20170247334A1

  公开（公告）日：2017-08-31

  A novel imidazole compound that yields a surface treatment liquid that is very effective at suppressing migration and oxidation of a wiring surface; a metal surface treatment liquid that contains the imidazole compound; a metal surface treatment method that uses the metal surface treatment liquid; and a laminate production method that uses the surface treatment liquid. A metal is surface-treated using the surface treatment liquid which includes a saturated fatty acid or a saturated fatty acid ester of a specific structure, in which a prescribed position is substituted by an aromatic group of a prescribed structure and an imidazolyl group that may have a substituent group.

  一种新型咪唑化合物，可产生一种表面处理液，该液非常有效地抑制导线表面的迁移和氧化；一种含有咪唑化合物的金属表面处理液；一种使用金属表面处理液的金属表面处理方法；以及一种使用表面处理液的层压板生产方法。使用包含饱和脂肪酸或饱和脂肪酸酯的表面处理液对金属进行表面处理，其中，预定位置被预定结构的芳基取代，并且可能带有取代基的咪唑基。
• Diffusing agent composition and method of manufacturing semiconductor substrate
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US10242874B2

  公开（公告）日：2019-03-26

  A diffusing agent composition and a method of manufacturing a semiconductor substrate using the diffusing agent composition. The diffusing agent composition contains an impurity diffusion component (A) including a first type of boron-containing compound and a second type of boron-containing compound.

  一种扩散剂组合物和一种使用该扩散剂组合物制造半导体衬底的方法。扩散剂组合物含有杂质扩散成分（A），包括第一种含硼化合物和第二种含硼化合物。