γ-Diazobuttersaeure-methylester | 591235-25-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: γ-Diazobuttersaeure-methylester
• 英文别名: ω-Diazo-buttersaeuremethylester；4-Diazo-buttersaeure-methylester；4-Diazo-buttersaeuremethylester；Methyl 4-diazobutanoate
• CAS: 591235-25-5
• 化学式: C₅H₈N₂O₂
• 分子量: 128.131
• InChiKey: LHOBIDIXFQQSEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  28.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  γ-Diazobuttersaeure-methylester 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 4-氯丁酸甲酯
  参考文献：
  名称：

  Hauptmann,S.; Hirschberg,K., Journal fur praktische Chemie (Leipzig 1954), 1966, vol. 34, p. 262 - 271

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(N-Nitroso-methoxycarbonylamino)-buttersaeure-methylester 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 生成 γ-Diazobuttersaeure-methylester
  参考文献：
  名称：

  Hauptmann,S.; Hirschberg,K., Journal fur praktische Chemie (Leipzig 1954), 1966, vol. 34, p. 55 - 63

  摘要：

  DOI：

文献信息

• Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides
  作者：Paul E. Finke、Bonnie M. Ashe、Wilson B. Knight、Alan L. Maycock、Manuel A. Navia、Shrenik K. Shah、Kevan R. Thompson、Dennis J. Underwood、Hazel Weston

  DOI：10.1021/jm00171a029

  日期：1990.9

  A variety of 7 alpha-methoxycephalosporin ester and amide sulfones were prepared and tested to determine the structure-activity relations for inhibition of human leukocyte elastase (HLE), a serine protease which has been implicated in several degenerative lung and tissue diseases. The most potent IC50 values were obtained with neutral, lipophilic derivatives, with the esters being more active than the amides. However, the best time-dependent inhibition in this series was observed with the p- and m-carboxybenzyl esters 7b and 7c. These results are discussed in terms of the proposed mechanism of inhibition as well as a molecular modeling study using the recently solved X-ray crystal structure of HLE.
• Hauptmann,S.; Hirschberg,K., Journal fur praktische Chemie (Leipzig 1954), 1966, vol. 34, p. 272 - 282
  作者：Hauptmann,S.、Hirschberg,K.

  DOI：——

  日期：——
• FINKE, PAUL E.;ASHE, BONNIE M.;KNIGHT, WILSON B.;MAYCOCK, ALAN L.;NAVIA, +, J. MED. CHEM., 33,(1990) N, C. 2522-2528
  作者：FINKE, PAUL E.、ASHE, BONNIE M.、KNIGHT, WILSON B.、MAYCOCK, ALAN L.、NAVIA, +

  DOI：——

  日期：——