1-(3-methoxy-1-propynyl)-4-trifluoromethylbenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-methoxy-1-propynyl)-4-trifluoromethylbenzene
• 英文别名: 1-(p-trifluoromethylphenyl)-3-methoxypropyne；1-(3-Methoxyprop-1-ynyl)-4-(trifluoromethyl)benzene
• 化学式: C₁₁H₉F₃O
• 分子量: 214.187
• InChiKey: PWXKVRPBFPSRMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  降冰片烯 、 三异丙基硅基乙炔 、 1-(3-methoxy-1-propynyl)-4-trifluoromethylbenzene 在 bis(1,5-cyclooctadiene)nickel (0) 、 二苯基甲氧基膦 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以66%的产率得到
  参考文献：
  名称：

  镍催化降冰片烯与两个炔烃的高度化学，区域和立体选择性三组分反应

  摘要：

  使用Ni（cod）2 /膦催化剂实现了降冰片烯与两个炔烃的第一个三组分反应，通过末端甲硅烷基乙炔的CH键活化反应生成1,5-炔烃。该反应适用于具有高区域和立体选择性的各种内部炔烃和降冰片烯衍生物。

  DOI：

  10.1021/ol9025556
• 作为产物：
  描述：

  对溴三氟甲苯 、 甲基炔丙基醚 在 bis(η3-allyl-μ-chloropalladium(II)) 、 Tedicyp copper(l) iodide 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以93%的产率得到1-(3-methoxy-1-propynyl)-4-trifluoromethylbenzene
  参考文献：
  名称：

  Coupling reactions of aryl bromides with 1-alkynols catalysed by a tetraphosphine/palladium catalyst

  摘要：

  cis. cis, cis-1, 2, 3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C3H5)](2) system catalyses efficiently the coupling reactions of aryl halides with a variety of alkynols such as propargy] alcohol, but-1-yn-4-ol, pent-1-yn-5-ol or hex-1-yn-6-ol. The catalyst can be used at lowloading. Higher reaction rates were observed in the presence of but-1-yn-4-ol, pent-1-yn-5-ol or hex-1-yn-6-ol than with propargy] alcohol. The protection of the alcohol functions as an ether or a silyloxy group led generally to similar or better results than the reactions performed with the unprotected alcohols. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.12.128

文献信息

• Highly Chemoselective Nickel-Catalyzed Three-Component Cross-Trimerization of Three Distinct Alkynes Leading to 1,3-Dien-5-ynes
  作者：Kenichi Ogata、Jun Sugasawa、Shin-ichi Fukuzawa

  DOI：10.1002/anie.200902099

  日期：2009.8.3

  Cross‐yned: The first highly chemoselective three‐component cross‐trimerization between a triisopropylsilylacetylene, an ether‐functionalized unsymmetrical internal alkyne, and a symmetrical internal alkyne leading to a 1,3‐dien‐5‐yne was achieved using a [Ni(cod)2]/PPh3 catalyst. This reaction is applicable for various internal alkynes with high regio‐ and stereoselectivities.

  交叉式：使用[Ni（ cod）2 ] / PPh 3催化剂。该反应适用于具有高区域和立体选择性的各种内部炔烃。
• Alkynoxy-Directed C–H Functionalizations: Palladium(0)-Catalyzed Annulations of Alkynyl Aryl Ethers with Alkynes
  作者：Yasunori Minami、Yuki Shiraishi、Tatsuro Kodama、Mayuko Kanda、Kotomi Yamada、Tomohiro Anami、Tamejiro Hiyama

  DOI：10.1246/bcsj.20150180

  日期：2015.10.15

  Palladium(0)-catalyzed insertion/annulation sequence between aryl silylethynyl ethers and internal alkynes was found to proceed through activation of ortho-C–H bonds assisted by alkynoxy groups and gave stereoselectively (Z)-2-silylmethylenechromenes. These products could be easily converted into 2,2-alkylated 2H-chromene derivatives, an important structural motif in medicinal chemistry and materials science. Various aryl silylethynyl ethers and alkynes can be transformed under the reaction conditions, and a wide range of chromenes is thus accessible. When unsymmetric alkynes are employed, a regioselective annulation takes place, especially those containing aryl and/or bulky substituents. Catalytic systems based on palladium(0), such as Pd(OAc)2/PCy3/Zn, [Pd(dba)2]/PCy3, or Pd(PCy3)2 exhibit excellent catalytic activity, and the best performance is observed for Pd(PCy3)2 in combination with Zn(OAc)2 as an additive. Substituents on the aryl group in the alkynyl aryl ethers rarely affect the reaction rate. Deuterium-labeling experiments suggest that the ortho-hydrogen atom migrates to the 2-methylene position in the chromene products. The cleavage of the C–H bond is considered to be the rate-determining step in these reactions.

  钯(0)催化的芳基硅乙炔醚与内烯的插入/环化反应发现，反应是通过烷炔醇基团辅助的邻位C–H键活化进行的，能够立体选择性地生成(Z)-2-硅基亚甲基色烯。这些产物可方便地转化为2,2-烷基化的2H-色烯衍生物，这在医药化学和材料科学中是一种重要的结构单元。在反应条件下，各种芳基硅乙炔醚和炔烃都可以被转化，因此可以获得广泛的色烯。当使用不对称炔烃时，会发生区域选择性的环化，特别是含有芳基和/或大取代基的情况。基于钯(0)的催化系统，如Pd(OAc)₂/PCy₃/Zn、[Pd(dba)₂]/PCy₃或Pd(PCy₃)₂展现出卓越的催化活性，并且在Pd(PCy₃)₂与Zn(OAc)₂作为添加剂结合时，表现最佳。阿尔基芳醚中芳基的取代基对反应速率几乎没有影响。氘标记实验表明，邻位氢原子迁移到色烯产物中的2-亚甲基位置。C–H键的断裂被认为是这些反应的速率决定步骤。