1-cyclopropylmethoxy-3-iodobenzene | 411229-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-cyclopropylmethoxy-3-iodobenzene
• 英文别名: 3-(Cyclopropylmethoxy)iodobenzene；1-(Cyclopropylmethoxy)-3-iodobenzene
• CAS: 411229-62-4
• 化学式: C₁₀H₁₁IO
• 分子量: 274.101
• InChiKey: CPQHVKPUMFIIRO-UHFFFAOYSA-N

物化性质

• 沸点：
  309.4±15.0 °C(predicted)
• 密度：
  1.663±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-碘苯酚 生成 1-cyclopropylmethoxy-3-iodobenzene
  参考文献：
  名称：

  Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-gamma binding agents

  摘要：

  揭示了替代吲哚类化合物，含有这类吲哚类化合物的药物组合物，以及它们在治疗或预防PPAR-γ介导的疾病或症状中的用途，如骨质疏松症、骨质疏松症、癌症、糖尿病和动脉粥样硬化。

  公开号：

  US20030087902A1

文献信息

• BIARYL DERIVATIVE AS GPR120 AGONIST
  申请人：LG Chem, Ltd.

  公开号：EP3239143A2

  公开（公告）日：2017-11-01

  The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

  本发明涉及一种由化学式1表示的生物芳基衍生物、生产该生物芳基衍生物的方法、包含该生物芳基衍生物的药物组合物以及该生物芳基衍生物的用途，由化学式1表示的生物芳基衍生物作为GPR120激动剂，促进胃肠道中GLP-1的生成、从巨噬细胞、胰腺细胞等的抗炎活性中降低肝脏、肌肉等的胰岛素抵抗，并可有效用于预防或治疗炎症或代谢性疾病，如糖尿病、糖尿病并发症、肥胖症、非酒精性脂肪肝、脂肪肝和骨质疏松症。
• Biaryl derivative as GPR120 agonist
  申请人：LG CHEM, LTD.

  公开号：US11261186B2

  公开（公告）日：2022-03-01

  Compounds having the chemical formula 1, a method for producing the compounds of chemical formula 1, a pharmaceutical composition comprising same, and use thereof as a GPR120 agonist for prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

  具有化学式1的化合物，制备所述化学式1化合物的方法，包含所述化合物的药物组合物，以及将其用作一种GPR120激动剂，用于预防或治疗炎症或代谢性疾病，如糖尿病、糖尿病并发症、肥胖症、非酒精性脂肪肝病、脂肪肝病和骨质疏松症。
• SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1341761A1

  公开（公告）日：2003-09-10
• US6787651B2
  申请人：——

  公开号：US6787651B2

  公开（公告）日：2004-09-07
• [EN] SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR- gamma BINDING AGENTS<br/>[FR] INDOLES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES CONTENANT CES INDOLES ET LEUR UTILISATION COMME AGENT DE FIXATION DE PPAR- DOLLAR G(G)
  申请人：BAYER AG

  公开号：WO2002030895A1

  公开（公告）日：2002-04-18

  Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-η mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.